7 papers · ranked by Valyu relevance
Nitesh Kumar Sharma, Ram Ayyala, Dhrithi Deshpande, Yesha M Patel + 11 more
Data-driven computational analysis is becoming increasingly important in biomedical research, as the amount of data being generated continues to grow. However, the lack of practices of sharing research outputs, such as data, source code and methods, affects transparency and reproducibility of studies, which are…
Tuomo Kiiskinen, Oscar Kivinen, Manuel A Rivas
The central problem of biology is the origin of biological organization. We show, using information theory, that an organism does not contain enough organism-specific information to specify its own fully functioning microscopic organization. The organized machinery of life is therefore not the execution of a fully…
Johanna L. Popp, Martin Weiß, Joshua Faskowitz, Kirsten Hilger
High neuroticism is a risk factor for mental disorders. Understanding whether individuals share a common foundation in brain function underlying neuroticism is therefore an essential goal of neuroscience. We applied Inter-Subject Representational Similarity Analysis on data from 174 Human Connectome Project…
Keith D. Harris, Guy Hadari, Gili Greenbaum
Modeling the dynamics of biological processes is ubiquitous across the ecological and evolutionary disciplines. However, the increasing complexity of these models poses a significant challenge to the dissemination of model-derived results. With the existing requirements of scientific publishing, most often only a small…
Gabriel Heckerman, Eileen Tzng, Arely Campos-Melendez, Chisomaga Ekwueme + 1 more
Several fields have described low reproducibility of scientific research and poor accessibility in research reporting practices. Although previous reports have investigated accessible reporting practices that lead to reproducible research in other fields, to date no study has explored the extent of accessible and…
Samantha L. Peters, Adair L. Borges, Richard J. Giannone, Michael J. Morowitz + 2 more
Metagenomic findings suggesting that bacteriophages (phages) can use genetic codes different from those of their host bacteria reveal a new dimension of phage-host interaction dynamics. Whereas reassignment of stop codons to code for amino acids has been predicted, there has been no proteomic validation of alternative…
Aaron M. Love, Nikhil U. Nair
As cellular engineering progresses from simply overexpressing proteins to imparting complex metabolic and regulatory phenotypes through multigene expression, judicious appropriation of cellular resources is essential. Since there is degeneracy in codons and their use is biased, codons may control cellular resources at…