7 papers · ranked by Valyu relevance
Hung Q. Vo, Huy Q. Vo, Son T. Ly, Zhihao Wan + 5 more
Conventional tissue image analysis software provides foundational capabilities for cellular analysis, including segmentation, basic morphological feature extraction, and spatial organization analysis. However, these tools often require manual intervention and are not well integrated with code-driven automation…
Yuqi Tan, Tim N. Kempchen, Martin Becker, Maximilian Haist + 7 more
Multiplexed imaging technologies provide insights into complex tissue architectures. However, challenges arise due to software fragmentation with cumbersome data handoffs, inefficiencies in processing large images (8 to 40 gigabytes per image), and limited spatial analysis capabilities. To efficiently analyze…
Tianhao Chu, Yuling Wu, Wentao Qiu, Zihao Jiang + 3 more
Localized space coding and phase coding are two distinct strategies responsible, respectively, for representing abstract structure and sensory observations in neural cognitive maps. In spatial representation, localized space coding is implemented by place cells in the hippocampus (HPC), while phase coding is…
Christoffer M. Langseth, Bastien Hervé, Hanna P. Piechaczyk, Yuk Kit Lor + 2 more
Spatial omics technologies enable high-resolution mapping of molecular and cellular organization within tissues, yet interactive exploration of these data remains challenging due to computational bottlenecks, and reliance on proprietary software infrastructures. We present KaroSpace, a framework for cell-centric…
Mengwei Hu, Yi Cui, Qianhui Huang, Khoi Chu + 18 more
SPAtial Cell Exploration (SPACE) is a novel subcellular imaging-based method that couples large-scale perturbations with whole transcriptome single-cell multi-omics readout, while preserving spatial context, providing unprecedented insights into tissue organization and microenvironmental interactions at very low cost.…
Christine M. Lykken, Benjamin R. Kanter, Anne Nagelhus, Jordan Carpenter + 3 more
A systems-level understanding of cortical computation requires insight into how neural codes are transformed across distinct brain circuits. In the mammalian cortex, one of the few systems where such transformations are tractable is the spatial mapping circuit. This circuit comprises interconnected regions of medial…
Guillermo Martín-Sánchez, Christian K. Machens, William F. Podlaski
Hippocampal remapping, in which place cells form distinct activity maps across different environments, is a well-established phenomenon with a range of theoretical interpretations. Some theories propose that remapping helps to minimize interference between competing spatial memories, whereas others link it to shifts in…