24 papers · ranked by Valyu relevance
Marta Czime Litwińczuk, Nelson Trujillo-Barreto, Nils Muhlert, Lauren Cloutman + 1 more
The relationship between structural and functional brain networks has been characterised as complex: the two networks mirror each other and show mutual influence but they also diverge in their organisation. This work explored whether a combination of structural and functional connectivity can improve predictive models…
Johannes Beller, Beatrice G. Kuhlmann, Stefanie Sperlich, Siegfried Geyer
Health, and Routine Activities Authors: ['Johannes Beller' 'Beatrice G. Kuhlmann' 'Stefanie Sperlich' 'Siegfried Geyer'] Objectives Limited evidence exists regarding the reasons for secular changes in cognitive functioning over historical time. Thus, we examined potential explanatory factors for changes in cognitive…
Eric D. Kirby, Brian Beyst, Jen Beyst, Sonia M. Brodie + 1 more
'Ryan C. N. D’Arcy'] Introduction Cognitive deficits are common in psychiatric and mental health disorders, making the assessment of cognitive function in mental health treatment an important area of research. Cognitive Function Development Therapy (CFDT) is a novel therapeutic modality designed to enhance cognitive…
Claudia-Lorena García, Mariana Salcedo-Gómez, Alejandro Vázquez-del-Mercado
'Alejandro Vázquez-del-Mercado'] In this paper, we articulate a functional approach to cognitive capacities. It is a restricted functionalism for various reasons, but especially because it does not claim that all cognitive (and/or mental) entities and processes are functional in the sense of a systemic capacities…
Shijie Qu, Yueyue Lydia Qu, Kwangsun Yoo, Marvin M. Chun
Cognitive control, the ability to adapt thoughts and actions to shifting contexts and goals, is composed primarily of three distinct yet interrelated components: Inhibition, Shifting, and Updating. While prior research has examined the nature of different cognitive components as well as their inter-relationships, fewer…
Marta Czime Litwińczuk, Nelson J. Trujillo‐Barreto, Nils Muhlert, Lauren Cloutman + 1 more
'Lauren Cloutman' 'Anna M. Woollams'] Authors: Marta Czime Litwińczuk a , Nelson Trujillo-Barretoa , Nils Muhlert a , Lauren Cloutmana , Anna Woollamsa Affiliations: a Division of Neuroscience and Experimental Psychology, University of Manchester, UK Corresponding author: Marta Czime Litwinczuk Email…
Jose A. Rodas, Afroditi A. Asimakopoulou, Ciara M. Greene
Meta-analyses have found that working memory (WM) can be improved with cognitive training; however, some authors have suggested that these improvements are mostly driven by biases in the measurement of WM, especially the use of similar tasks for assessment and training. In the present meta-analysis, we investigated…
Timothy S. Marks, Gordon Muir Giles, Dorothy Farrar Edwards
Background Understanding the association of older adults’ cognitive ability with performance of instrumental activities of daily living (IADL) is critical to identifying their community health care support needs. We compared differences in performance-based IADL assessment scores among older adults according to their…
Marko Živanović, Jovana Bjekić, Saša R. Filipović
Human cognitive abilities depend on flexible coordination across distributed cognitive control systems within the frontoparietal network, yet the causal architecture linking executive functions (EFs) to higher cognition remains debated. We combined psychometric modeling and neuromodulation to test causal contributions…
Erik Hessen
1. Patients who achieve normal function on neuropsychological testing generally have normal brain function (). Individuals with high brain reserve and cognitive reserve () are more resistant to both brain and cognitive changes, and can have good cognitive performance even with underlying brain pathology. These…
Yasunori Yamada, Kaoru Shinakwa, Masatomo Kobayashi, Miyuki Nemoto + 3 more
'Miho Ota' 'Kiyotaka Nemoto' 'Tetsuaki Arai'] Abstract—Detection of subtle deficits in everyday functioning due to cognitive impairment is important for early detection of neurodegenerative diseases, particularly Alzheimer's disease. However, current standards for assessment of everyday functioning are based on…
Authors not listed
TIMP2 (Tissue Inhibitor of Metalloproteinase-2) plays a crucial role in hippocampal neuroplasticity and cognitive function through MMP-independent signaling. Despite its therapeutic promise, TIMP2 has long been considered 'undruggable' due to its cryptic surface topology and lack of canonical active sites. We present a…
Elmo P. Pulli, Saara Nolvi, Eeva Eskola, Elisabeth Nordenswan + 14 more
Non-verbal cognitive ability predicts multiple important life outcomes, e.g., school and job performance. It has been associated with parieto–frontal cortical anatomy in prior studies in adult and adolescent populations, while young children have received relatively little attention. We explored the associations…
Niklas Vockert, Judith Machts, Luca Kleineidam, Aditya Nemali + 37 more
The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration. Here, we tested this hypothesis in the Alzheimer’s disease continuum using longitudinal data from 490 participants of the DELCODE multicentric…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in brain, along with neuroinflammation and synaptic dysfunction. Genetic…
Heming Zhang, Chun Meng, Xinyu Xu, Xin Hu + 3 more
Working memory is a key component of intelligence, which can be underpinned by task connectome, while cognitive flexibility plays a role in adaptive and executive function that supports working memory processes. However, it remains unknown how intelligence and cognitive flexibility modulate working memory functioning…
Tasnim Irtifa Chowdhury, Andrew Vargo, Chris Blakely, Benjamin Tag + 1 more
'Koichi Kise'] In Human-Computer Interaction (HCI) and Ubiquitous Computing, the objective of optimizing device interactions and personalizing user experiences has placed a new emphasis on accurately evaluating cognitive readiness using wearable devices. Interpreting cognitive readiness in real-world scenarios is…
Daniel Faber, Gerrit M. Grosse, Martin Klietz, Susanne Petri + 4 more
'Philipp Schwenkenbecher' 'Kurt-Wolfram Sühs' 'Bruno Kopp' 'Grazia Spitoni'] Neuropsychological assessment needs a more profound grounding in psychometric theory. Specifically, psychometrically reliable and valid tools are required, both in patient care and in scientific research. The present study examined convergent…
Jun Chen, Anqi Chen, Bingkun Jiang, Mohammad S. Obaidat + 2 more
Cognitive State Evaluation Authors: ['Jun Chen' 'Anqi Chen' 'Bingkun Jiang' 'Mohammad S. Obaidat' 'Li Ni' 'Xinyu Zhang'] Abstract—Cognition refers to the function of information perception and processing, which is the fundamental psychological essence of human beings. It is responsible for reasoning and…
Fateme Zare, Paniz Sedighi, Mehdi Delrobaei
—Executive function, also known as executive control, is a multifaceted construct encompassing several cognitive abilities, including working memory, attention, impulse control, and cognitive flexibility. To accurately measure executive functioning skills, it is necessary to develop assessment tools and strategies that…
Akash K Rao, Shashank Uttrani, Vishnu K Menon, Darshil Shah + 3 more
EEG-based functional connectivity and machine learning methods Authors: ['Akash K Rao' 'Shashank Uttrani' 'Vishnu K Menon' 'Darshil Shah' 'Arnav Bhavsar' 'Shubhajit Roy Chowdhury' 'Varun Dutt'] Abstract. Predicting and understanding the changes in cognitive performance, especially after a longitudinal intervention, is…
Authors not listed
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and widespread neurovascular disturbances. Traditional fMRI provides valuable spatial maps of blood-oxygen-level-dependent (BOLD) changes but often lacks the capacity to quantify the interplay of cerebral blood flow…
Muhammad Aziz
Dementia is the most common disease globally and one of the leading causes of disability and disease burden worldwide. The proposed research was designed for the isolation and identification of cholinesterase inhibitors, anti-inflammatory compounds, and compounds that accentuate cardiac and oral toxicity. A…
Jiwon Lee
Dopamine is a hormone that is released by the adrenal gland and influences motor control and motivation. Dopamine is known to have 5 receptors which are D1, D2, D3, D4 and D5, which are further categorized into 2 families: D1 family and D2 family. The D1 family is known to play a role in motivation and motor control…