24 papers · ranked by Valyu relevance
Hannah J. Lords, Mengze Li, Zeyuan Song, Anastasia Leshchyk + 13 more
Cognitive performance is central to health and quality of life. Studying the factors that sustain performance may offer insights into maintaining cognitive function into advanced ages and may inform strategies to promote healthy cognitive aging. To identify single nucleotide polymorphisms (SNPs) underlying cognitive…
Sonia Montemurro, Enrico Bovo, Giulia Sebastianutto, Giovanna Boccuzzo + 1 more
Introduction Cognition involves interconnected functions which may overlap across tasks. Thus, neuropsychological assessment should be optimized in tests, while integrating socio-demographic and socio-cultural factors like Sex and Cognitive Reserve (CR). This study aims to (1) determine whether a global cognitive…
Elisabeth Mai, Christof Meigen, Ricarda Schmidt, Juliane Ludwig + 2 more
1## Introduction The word “cognition” is derived from the Latin word “cognoscere,” which means to realize or to experience (). In general, cognitive functions are defined as brain-based mental processes that encompass perceiving, acquiring, storing, transforming, and processing information (; ). Consequently, cognitive…
Wenjie Pan, Cheng Xu, Cheng Zhu, Jiaojiao Wang
Objectives Structural gray matter changes were significantly observed in cognitively normal elderly adults, but the associations between different structural brain patterns, executive function, and general cognitive ability in older adults have not been fully explored. Methods A total of 119 cognitively normal elderly…
Marko Živanović, Jovana Bjekić, Saša R. Filipović
Human cognitive abilities depend on flexible coordination across distributed cognitive control systems within the frontoparietal network, yet the causal architecture linking executive functions (EFs) to higher cognition remains debated. We combined psychometric modeling and neuromodulation to test causal contributions…
Jin‐Hao Yang, Shaojiong Zhou, Zhibin Wang, Jiahua Xu + 13 more
Jinhao Yang a,b,1 , Shaojiong Zhou c,1 , Zhibin Wang c , Jiahua Xu a,b , Jia Cheng a,b , Zhouqian Yin a,b , Tao Wei c , Chaofan Geng c , Xiaoduo Liu c , Xiang Lia,b , Xiaoyu Zhou a,b , Kun Lid,e , Ruolei Gu f,g , Raymond Dolan a,h,i, Yi Tang c,j,\ & Yunzhe Liu a,b,\
Authors not listed
TIMP2 (Tissue Inhibitor of Metalloproteinase-2) plays a crucial role in hippocampal neuroplasticity and cognitive function through MMP-independent signaling. Despite its therapeutic promise, TIMP2 has long been considered 'undruggable' due to its cryptic surface topology and lack of canonical active sites. We present a…
Margaret Gatz, Jill E. Darling, Stefan Schneider, Ying Liu + 6 more
Cognitive epidemiology explores cognitive ability as a risk factor for various health and disease-related outcomes. To support research in this area, the Understanding America Study (UAS)-a nationally representative online probability sample-has developed and collected longitudinal assessments of multiple cognitive…
Rolando Bonandrini, Marco Tettamanti, Claudio Luzzatti
Reconciling the anatomical observation that the human brain comprises two asymmetrical halves with the phenomenal unity of the mind is a puzzle that has challenged neuroscientists since the dawn of research in the field. White-matter commissural fibres of the corpus callosum constitute a critical anatomical substrate…
Chidera Okoro, Tan Lai Zhou, Carla JH van der Kallen, Sebastian Kohler + 2 more
Background With increasing life expectancy, more individuals will face age-related cognitive difficulties, including Alzheimer's disease. It is, therefore, important to identify early, potentially modifiable risk factors for cognitive impairment. Lower heart rate variability (HRV), reflecting worse cardiac autonomic…
Frank Ho-yin Lai, Kathy Ka-ying Yu, Eddie Yip-kuen Hai, Ben Chi-bun Yip + 2 more
Cognitive deficits such as attentional impairment and executive dysfunction significantly impact daily living activities in older adults with dementia. This study aimed to evaluate the efficacy of Cognitive Stimulation Therapy (CST) compared to Reality Orientation & Reminiscence Therapy (RO&RM) in improving attention…
Xiangyang Wang, Fan Wang, Weiwei Wang, Chaoshuai Hu + 3 more
This research sought to assess the relationship between LC9 and cognitive function among older adults in the United States. Data were sourced from the U.S. National Health and Nutrition Examination Survey 2011 to 2014. LC9 scores were derived from 9 health behaviors and factors. Cognitive function was evaluated using…
Richard N. Henson
The term ‘cognitive reserve’ broadly refers to better-than-expected cognitive abilities in old age, presumed to reflect environmental/lifestyle factors earlier in life. This commentary addresses the question of what determines ‘better than expected’ cognition; specifically, whether cognitive reserve can be ‘explained…
Junjie Wu, Benjamin B Risk, Taylor A James, Nicholas Seyfried + 5 more
\ James J. Lah, MD, PhD, Department of Neurology, Emory University, 6 Executive Park Dr NE, Atlanta, GA 30329, USA. Telephone: (+1) 404-727-3509. E-mail: jlah@emory.edu \ Deqiang Qiu, PhD, Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd NE, Atlanta, GA 30322, USA. Telephone: (+1)…
Matthew J. Euler, Kirsten Hilger
Human intelligence is essential to understand complex ideas, to engage in various forms of reasoning, to learn from experience, and to adapt to new situations by taking thought. The P300 event-related brain potential has been related to intelligence scores and thus represents as a promising biomarker of general…
Yue Hong, Christa Michel, Gabriele Maria Gassner, Courtney Accorsi + 28 more
Significant effort has been put towards mapping patterns of atrophy in the cerebral cortex that are related to pathological aging, including the characteristic patterns of neurodegeneration in Alzheimer’s disease (AD). In contrast, brain structural patterns that support preserved or even exceptional cognition…
Damien Marie, Dimitra Kokkinou, Chantal Junker-Tschopp, Matthias Kliegel + 4 more
Hippocampal atrophy and altered functional connectivity are prominent features of mild cognitive impairment (MCI), yet their relationships and joint contribution to cognitive impairment remain unclear. We evaluated multidomain cognitive-sensorimotor performance, whole-brain gray matter atrophy patterns, associated…
Mohammad Asif, Azizuddin Khan, Mohd Azam, Anurag Rajkumar Bombarde
As populations age, cognitive decline from mild cognitive impairment (MCI) to dementia is a defining health challenge of the coming decades, yet routine assessment often misses its earliest signs. This article critically synthesizes recent technological advances for detecting and managing cognitive impairment in older…
Qaremohammadlou, Mohaddese, Shamsollahi, Mohammad Bagher
This study investigates brain connectivity and information flow during mental workload (MWL) by integrating electroencephalogram (EEG) and functional near-infrared spectroscopy (fNIRS) signals. Utilizing the N-back task to induce varying levels of MWL in 26 participants, we analyzed both functional and effective…
Maria del C. Valdes-Hernandez, Wonjung Park, Joanna Moodie, Susana Muñoz Maniega + 6 more
The study of brain morphology changes in normal individuals may capture aspects of functionally-relevant brain aging not fully indicated by gross volumetry. Despite the important role of subcortical brain structures in cognition, the associations between their morphological trajectories and cognitive changes in aging…
Xiongri Shen, Jiaqi Wang, Zhenxi Song, Yi Zhong + 4 more
Mild cognitive impairment (MCI) and subjective cognitive decline (SCD) are closely associated with the early Alzheimer's disease continuum, where accurate and explainable diagnosis is important for early risk assessment and intervention. Existing connectome-based deep learning models can improve classification…
Authors not listed
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and widespread neurovascular disturbances. Traditional fMRI provides valuable spatial maps of blood-oxygen-level-dependent (BOLD) changes but often lacks the capacity to quantify the interplay of cerebral blood flow…
Authors not listed
Alzheimer's disease (AD) is a neurodegenerative disorder caused by multiple factors that require the development of multi-target directed ligands (MTDL) to treat its pathophysiology. Using Hyperoside, a major Himalayan plant extract, this study will report on the potential use of this compound as a therapeutic agent…
Authors not listed
The amyloid-β (Aβ) peptides are crucial biomarkers for the diagnosis of Alzheimer's disease (AD), the most common neurodegenerative disease. The high diversity of the Aβ family provides a significant challenge for recognizing various Aβ forms, which may differ by a single amino acid or a post-translational…