18 papers · ranked by Valyu relevance
Lars Tebbe, Larissa Ikelle, Mustafa S. Makia, Mashal Kakakhel + 2 more
Syntaxin 3 (STX3), a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family, plays a central role in vesicle fusion. Beyond its synaptic localization, STX3 is also detected in the photoreceptor inner segment, where its function remains poorly understood. It is shown that STX3…
Marion E. Cahill, Kathryn Chmelik, Brooke A. Brothers, Madyson E. Ashcraft + 7 more
Blue cone monochromacy (BCM) is an X-linked cone dystrophy characterized by loss of long- (L) and medium-wavelength (M) cone function. A common cause is the C203R missense mutation, which occurs in both OPN1LW and OPN1MW, or in hybrid OPN1LW/OPN1MW opsin genes. Because BCM primarily affects foveal cones, we generated…
Benjy Firester, Raphael Tsiamis, Yipeng Wang
We construct non-flat minimal capillary cones with bi-orthogonal symmetry groups for any dimension and contact angle. These cones interpolate between rescalings of a singular solution to the one-phase problem and the free-boundary cone obtained by halving a Lawson cone along a hyperplane of symmetry. The existence and…
Chi Sun, Michael Fitzpatrick, Daniel Kerschensteiner, Shiming Chen
Cone-rod dystrophies (CoRD) are inherited retinal diseases (IRDs) with variable ages of onset, characterized by the progressive loss of cones, followed by secondary degeneration of rods. Cone-rod homeobox (CRX) is a transcription factor that regulates gene expression essential for photoreceptor development and…
Papri Dey
Lorentzian and completely log-concave polynomials have recently emerged as a unifying framework for negative dependence, log-concavity, and convexity phenomena in combinatorics and probability. We extend this framework to variational analysis and cone-constrained dynamics by studying K-Lorentzian and K-completely…
Hannah K. Doyle, James Fong, Ren Ng, Austin Roorda
Retinal degenerative diseases progressively erode the cone photoreceptor mosaic, reducing the retina’s spatial sampling power, yet visual acuity is remarkably resilient to cone loss. Prior work has shown that clinically normal visual acuity (20/25 or better) can persist despite up to 50% of cone cells being lost (35…
Maxwell J. Greene, Vimal P. Pandiyan, Ramkumar Sabesan, William S. Tuten
The distribution of long (L)-, middle (M)-, and short (S)-wavelength sensitive cones in the retina determines how different frequencies of incident light are sampled across space and has been hypothesized to influence spatial and color vision. We examined how the detection and color naming of small, short-duration…
Nicolas P. Cottaris, Brian A. Wandell, David H. Brainard
Accurate image-computable models of retinal ganglion cell (RGC) mosaics across the retina do not currently exist. Here, we deploy a novel computational frame-work which synthesizes mosaics of linear spatio-chromatic receptive fields (RFs) of ON midget RGCs (mRGCs) by integrating published anatomical, physiological, and…
Maya Tang, Paul S.-H. Park, Takeshi Iwata
Opsins are the light receptors in retinal rod and cone photoreceptor cells that initiate vision in response to a light stimulus. Rhodopsin is the opsin in rods, and the influence of mutations that disrupt its structure and function has been characterized in detail. Less is known about cone opsins, the opsins in cones…
Trong Thuan Ung, Gillian N. Huskin, Sanford Boye, Yuchen Wang
Synaptic dysfunction and neurite remodeling are early features of many inherited retinal diseases, but whether synaptic function can be restored after circuit remodeling remains unclear. We evaluated the therapeutic potential of adeno-associated virus (AAV)-mediated α2δ4 gene supplementation in a mouse model of…
Matthew Yedutenko, Marcus H.C. Howlett, Gabrielle van der Veen, Maarten Kamermans
Photoreceptors gate and shape visual information. Since perception ultimately guides action, the way photoreceptors transform light into neural signals constrains an animal’s behavioural repertoire. Yet, the physiological role of the highly conserved calcium-dependent chloride current in cone photoreceptors has…
Sheida Hashemi, Sara Y. Sabbagh, Khushi Talajia, James Fortenberry + 3 more
Variants in the X-linked gene CASK are associated with neurodevelopmental defects. Animal model studies have demonstrated that conditions such as cerebellar hypoplasia, microcephaly, and optic nerve hypoplasia (ONH) are related to loss-of-function (LOF) in the CASK gene. CASK variants are associated with multiple…
Riccardo Cristoferi, Devin van der Gulik
We determine the explicit value of the optimal constant in the trace inequality for functions of bounded variations in the case the domain has a particular class of singularities.
Cheng Long, David R. Nelson
We generalize the analytic theory and simulation models for liquid crystal ground states on conventional cones with positive apex Gaussian curvature and study liquid crystal ground states on hyperbolic cones with a delta function of negative apex Gaussian curvature. While both the local apex curvature on a conventional…
Aditya Acharya, Auguste Henry Gezalyan, David M. Mount, Danesh Sivakumar
The forward and reverse Funk weak metrics are fundamental distance functions on convex bodies that serve as the building blocks for the Hilbert and Thompson metrics. In this paper we study Voronoi diagrams under the forward and reverse Funk metrics in polygonal and elliptical cones. We establish several key geometric…
Adree Songco Aguas, Fred Rieke, Gabrielle J. Gutierrez
Under mesopic conditions, such as dawn or dusk, signals from both rod and cone photoreceptors contribute to perception. These parallel inputs are combined within the retina before being sent to subsequent visual areas. The integration of these kinetically-distinct parallel signals poses unique challenges for human…
Luis Manuel Arvizu, Eleuterio Castaño, Norberto Aquino, Alessandro Sergi
In this work, we solve the Schrödinger equation for a hydrogenic impurity located at the apex of a right circular cone, with the electron constrained to move on the conical surface of semi-aperture angle $θ_{0}$ and subjected to an Aharonov-Bohm magnetic flux along the symmetry axis. Analytical expressions for the…
Minghao Li, Ruixin Fu, Dongsheng Wu, Lijuan Zhao + 1 more
As a core crushing equipment in mining, building materials, and related industries, the cone crusher relies heavily on the optimal design and health state prediction of its mantle liner to enhance equipment reliability and reduce maintenance costs. This paper proposes a comprehensive approach integrating dynamic…