27 papers · ranked by Valyu relevance
Cha Yee Kuen, Mas Jaffri Masarudin, Alexandru Grumezescu
Lung cancer has been recognized as one of the most often diagnosed and perhaps most lethal cancer diseases worldwide. Conventional chemotherapy for lung cancer-related diseases has bumped into various limitations and challenges, including non-targeted drug delivery, short drug retention period, low therapeutic…
N. Abbasnezhad, N. Zirak, M. Shirinbayan, S. Kouidri + 3 more
In this study, polyurethane-films loaded diclofenac were used to analyze the drug release kinetics and mechanisms. For this purpose, the experimental procedures were developed under static and dynamic conditions with different initial drug loads of 10, 20, and 30%. In the dynamic condition, to better simulate the…
Filipa Bettencourt, Patrícia C. Pires, Francisco Veiga, Ana Cláudia Paiva-Santos + 4 more
The development of oral drug delivery systems has become a major priority for pharmaceutical technology, driven by the growing demand for medicinal products that improve compliance, enhance therapeutic efficacy, and minimise drug-related adverse effects. Therefore, the ability to modulate drug release kinetics through…
Authors not listed
Purpose Chemotherapy is frequently limited by low drug bioavailability and significant side effects, such as nausea. This study aims to develop a nanocarrier-based sustained drug delivery system using chitin nanofibers (NC) to enhance therapeutic efficacy while minimizing adverse effects. Methods Chitin nanofibers were…
Authors not listed
Different classes of ordered porous materials, metal-organic frameworks and titanosilicates, with potential as nitric oxide (NO) delivery carriers are combined with a biocompatible hydrophobic polymer, polycaprolactone (PCL), to obtain a more clinically practical format and to improve the delivery kinetics and…
Liu-Huan Yi, Jian Qin, Si-Ran Lu, Liu-Pan Yang + 3 more
'Huan Yao' 'Carmine Gaeta'] Intelligent controlled-release drug delivery systems that are responsive to various external stimuli have garnered significant interest from researchers and have broad applications in the biomedical field. Aromatic macrocycles, including calixarenes and pillararenes, are considered ideal…
Lotter, Sebastian, Seiter, Marco + 8 more
—Recently, bacterial nanocellulose (BNC), a biological material produced by non-pathogenic bacteria that possesses excellent material properties for various medical applications, has received increased interest as a carrier system for drug delivery. However, the vast majority of existing studies on drug release from…
Kamran Ahmad Khan, Ashfaq Ahmad, Carlotta Marini, Mario Nicotra + 5 more
'Alessandro Di Cerbo' 'Fazal-Ur-Rehman' 'Naveed Ullah' 'Gul Majid Khan' 'Juan Torrado'] In the current study, matrices of losartan potassium were formulated with two different polymers (Ethocel 10 premium and Ethocel 10FP premium), along with a filler and a lubricant, at different drug-to-polymer w/w ratios (10:3…
Yangchao Zhou, Moonkwang Jeong, Meng Zhang, Xuexin Duan + 1 more
On-demand controlled drug delivery is essential for the treatment of a wide range of chronic diseases. As the drug is released at the time when required, its efficacy is boosted and the side effects are minimized. However, so far, drug delivery devices often rely on the passive diffusion process for a sustained…
Alfred Najm, Elena-Theodora Moldoveanu, Adelina-Gabriela Niculescu, Alexandru Mihai Grumezescu + 3 more
'Alexandru Mihai Grumezescu' 'Mircea Beuran' 'Bogdan Severus Gaspar' 'Andrea Telek'] Since sarcopenia is a progressive condition that leads to decreased muscle mass and function, especially in elderly people, it is a public health problem that requires attention from researchers. This review aims to highlight drug…
Laura Donato, Paola Bernardo, Huacheng Zhang
Controlled drug delivery systems (CDDSs) are increasingly attracting interest from the scientific community in order to achieve highly precise, customized, and efficient therapeutic treatment of various diseases. The challenge is to develop highly innovative devices and appropriate administration methods in order to…
Eduardo A. Chacin Ruiz, Katelyn E. Swindle-Reilly, Ashlee N. Ford Versypt
Chronic diseases often require repeated oral or local administration, which can compromise patient compliance. In wet age-related macular degeneration (AMD), current therapies rely on intravitreal injections of anti-vascular endothelial growth factor agents every four to six weeks to maintain therapeutic drug levels.…
Richard Ziegler, Shaista Ilyas, Sanjay Mathur, Gerardo F. Goya + 1 more
- 1 Institute of Inorganic Chemistry, University of Cologne, Greinstr. 6, 50939 Cologne, Germany; richie.ziegler@arcor.de (R.Z.); silyas@uni-koeln.de (S.I.); sanjay.mathur@uni-koeln.de (S.M.) - 2 Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Campus Río Ebro, 50018 Zaragoza…
Sergio Ayala-Mar, Oju Jeon, Pedro Chacón-Ponce, José González-Valdez + 1 more
Local and controlled delivery of exosomes using hydrogels can improve the efficacy of exosome-based therapeutics. Hydrogels based on oxidized and methacrylated alginate (OMA) can be produced through photocrosslinking and exhibit controllable degradability. The degradation properties of OMA hydrogels can be tailored by…
Authors not listed
“Click to release” chemistry enables bioorthogonal bond cleavage and controlled release via a click-type ligation reaction serving as both the trigger and means of localization. Extending this concept beyond covalent ligation reactions, we introduce a non-covalent click-to-release strategy based on…
Rienk Eelkema, Benjamin Klemm, Magherita Tavasso, Irene Piergentili + 3 more
We present a new method to obtain tertiary amine-based prodrugs with dual functionality, enabling (i) signal-triggered drug activation and (ii) covalent incorporation in polymer materials through a clickable azido-group unit on the molecular prodrug scaffold. Using nucleophilic substitution on an electron deficient…
Elliot J. Carr, Giuseppe Pontrelli
Advances in material design has led to the rapid development of novel materials with increasing complexity and functions in bioengineering. In particular, functionally graded materials (FGMs) offer important advantages in various fields of application. In this work, we consider a heterogeneous reaction-diffusion model…
Dorin Ioan Cocoș, Olimpia Dumitriu Buzia, Alin Laurențiu Tatu, Monica Dinu + 5 more
'Monica Dinu' 'Lawrence Chukwudi Nwabudike' 'Claudia Simona Stefan' 'Kamel Earar' 'Carmen Galea' 'Paola Mura'] In this study, we focused on innovative approaches to improve drug administration in oral pathology, especially by transmucosal and transdermal pathways. These improvements refer to the type of microneedles…
Elliot J. Carr
In diffusion-controlled drug delivery, it is possible for drug molecules to bind to the carrier material and never be released. A common way to incorporate this phenomenon into the governing mechanistic model is to include an irreversible first-order reaction term, where drug molecules become permanently immobilised…
Corinna Schlosser, Wojciech Rozek, Ryan Mellor, Szymon Manka + 3 more
Teriparatide (and analogue peptides) are the only FDA approved anabolic treatments for osteoporosis. Current therapies are administered as a daily subcutaneous injection, which limits patient adherence and clinical efficacy. To achieve the desired anabolic effect, a controlled delivery system must ensure a pulsatile…
Authors not listed
Spatiotemporal control of molecular release is essential for the precise manipulation of cellular functions, and photo-stimulation is one of the most widely used strategies to achieve this control. However, direct light exposure can cause cell damage due to the generation of reactive oxygen species and photothermal…
Jason Li, Benjamin G. Clark, Parmiss Khosravi, Colin Cotter + 23 more
Reversible contraceptives empower women to prevent unintended pregnancies and enable family planning. However, the need for frequent dosing with pills or injections often leads to suboptimal medication adherence and reduced effectiveness–an issue common to many chronic conditions. Long-acting drug delivery implants…
Bhaskar C. Das, Parthiban Chokkalingam, Pavithra Masilamani, Srushti Shukla + 2 more
'Srushti Shukla' 'Sasmita Das' 'Ion Romulus Scorei'] Drug delivery systems, which use components at the nanoscale level as diagnostic tools or to release therapeutic drugs to particular target areas in a regulated manner, are a fast-evolving field of science. The active pharmaceutical substance can be released via the…
Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr + 10 more
Bioorthogonal bond-cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, the tetrazine-triggered elimination of cleavable trans-cyclooctenes (click-to-release) stands out due to high reaction rates…
Denise Murgia, Bianca Martins Estevão, Corinne Portioli, Roberto Palomba + 1 more
Polymeric microparticles find extensive use in several pharmaceutical applications. Our group has developed poly(lactic-co-glycolic acid) (PLGA) microPLates (μPL) featuring a square base of 20×20 μm and a height of 10 μm, for the controlled and sustained delivery of a range of therapeutic payloads, including…
Sohyung Lee, Spencer Zhao, Xinyang Chen, Lingyun Zhu + 12 more
Although hydrophilic drugs represent a large proportion of all therapeutics used to treat and manage chronic diseases, achieving their ultra-long-term delivery via an injectable system remains a major challenge. Implants have demonstrated potential for long-term delivery of both hydrophobic and hydrophilic drugs…
Sophia R. Dasaro, Shruti S. Sawant, Alexa Stern, Lucas D. Johnson + 8 more
Liquid crystalline mesophases exhibit structurally programmable internal architectures that enable co-loading of chemically orthogonal molecules within a single composite material. Realizing the potential of these materials for drug delivery requires a quantitative understanding of how tuning the composition affects…