6 papers · ranked by Valyu relevance
Alex Sheremet, Yuchen Zhou, Jack P. Kennedy, Yu Qin + 2 more
Cross-frequency coupling in the hippocampus has been hypothesized to support higher-cognition functions. While gamma modulation by theta is widely accepted, evidence of phase-coupling between the two frequency components is so far unconvincing. Our observations show that theta and gamma energy increases with rat speed…
Manato Okahara, Teruyuki Niimi, Shinichi Morita
Exaggerated insect traits often show positive allometry, yet nonlinear scaling can reflect either continuous curvature or discrete morphs. Distinguishing between these alternatives is important because they imply different developmental and evolutionary scenarios. Using cross-sectional data from 1,000 adult Oryctes…
Santosh Manicka, Kathleen Johnson, Michael Levin, David Murrugarra
The extent to which the components of a biological system are (non)linearly regulated determines how amenable they are to therapy and control. To better understand this property termed ‘regulatory nonlinearity’, we analyzed a suite of 137 published Boolean network models, containing a variety of complex nonlinear…
Yue Yu, Anchi Cheng, Elizabeth Montabana, Noeli Paz Soldán + 24 more
The laser phase plate (LPP) enables phase-contrast imaging in cryogenic electron microscopy (cryoEM), enhancing image contrast without compromising high-resolution information. Here we report the implementation of a crossed laser phase plate (xLPP) comprising two optical cavities oriented orthogonally, installed in a…
Liam Shaughnessy, Lauren Vannell, Sulekh Fernando-Peiris, Cristina Rodríguez
Three-photon microscopy enables deep-tissue imaging but is highly sensitive to excitation pulse quality, since three-photon excitation efficiency scales with the cube of instantaneous intensity. Group-delay dispersion (GDD) and third-order dispersion (TOD) accumulated through the laser and microscope optics can…
Xiaomeng Jia, Warren S. Warren
Nonlinear optical microscopy modalities have become widely used in applications ranging from material characterization to tissue diagnosis. In complex systems, multiple mechanisms often contribute to the signal; for example, two-color pump-probe microscopy provides rich molecular signatures of the samples based on…