2 papers · ranked by Valyu relevance
Giansalvo Cirrincione, Elisa Ficarra, Marta Lovino
Protein language models (pLMs) such as ESM-2 and ProtBERT rely on pretraining corpora of tens to hundreds of millions of sequences and on encoder architectures whose depth, width and number of attention heads are chosen by the practitioner and never revisited during training. The entry cost of state-of-the-art pLMs is…
Bach Tran Nguyen, Aurélie Barrail-Tran, Moreno Ursino, Sébastien Goutal + 6 more
First-in-human studies require dose extrapolation from pharmacokinetic animal studies combined with safety assessments. Subtherapeutic doses of radiolabelled drugs can be administered in preclinical and early clinical development to gain a dynamic pharmacokinetic understanding, potentially informing…