8 papers · ranked by Valyu relevance
Yao Shen, Ziyang Yu, Qinfeng Zhu, Zhiyong Zhao + 7 more
Bridging the gap between macroscopic neuroimaging and microscopic histology remains a challenge in neuroscience. Here, we present a technical feasibility study of diffusion MR microscopy (dMRM) in the ex vivo human hippocampus using a 14.1 T ultrahigh-field MRI system. Mid-hippocampal blocks from control and…
Peter F. Pelz, Tobias Meck
For nearly a century, the physical origin of metabolic scaling has remained unresolved: metabolism is proportional to body mass in small organisms but follows Kleiber’s three-quarter-power law in larger animals. We derive both regimes from the Metabolic Holon (MH), a locally optimized capillary–tissue oxygen-supply…
Marie Drottar, Chan-Mi Kim, Howard J. Cabral, Corinna M. Bauer + 1 more
Our results demonstrate that CVI may be associated with an atypical regional white matter diffusion profile within specific segments of the CC, which may reflect underlying differences in tissue composition. Indeed, the genu, isthmus, and splenium all showed significant differences in diffusion properties as compared…
Kapali Suri, Anshul Yadav, Abhishek Tripathi, N. Arul Murugan
Protein-ligand pose prediction is central to structure-based drug discovery, yet the relative performance of physics-based and AI-driven methods under realistic cross-docking conditions remains insufficiently characterized. Here, we compare physics-based docking methods (AutoDock4, AutoDock Vina, and DOCK 6) with…
Leila Motamed Jahromi, Lin Yang, Alexander von Lühmann, Dirk Grosenick
Significance Functional near-infrared spectroscopy (fNIRS) and oximetry are important noninvasive methods to investigate physiological processes and states in the human brain and muscle tissue. Self-calibrating probe methods combine two light sources with typically two detectors to improve the stability of…
Andreas Carlsson, Ulf Olsson, Sara Linse
In Alzheimer’s disease (AD), the aggregation of amyloid β (Aβ) peptides has been linked to disease pathology. Once aggregates have formed, existing fibrils catalyze the formation of new fibrils in a runaway process associated with neuro degeneration. One component of the cellular defense system against amyloid…
Alba Cortés‐Martínez, Francisco Sánchez‐Férez, José A. Suárez del Pino, Sergio Royuela + 3 more
The development of porous materials that combine low-temperature meltability with high gas uptake remains a major challenge. Herein, we report Cu-BCN-5, a polymer-grafted Cu(II) metal-organic polyhedron (MOP), as a scalable melt-processable material with intrinsic porosity. This material melts at 44°C while preserving…
Eider David Torres, María Laura Grasso, Fabiana Gennari, Pierre Arneodo Larochette
Although Li4SiO4-based sorbents show great potential for high-temperature CO2 capture, conventional formulations derived from pure SiO2 suffer from high synthesis costs and kinetic limitations. This work proposes a sustainable alternative by utilizing raw, unpurified natural diatomite from Río Negro (Argentina) as the…