4 papers · ranked by Valyu relevance
Amélie Barozet, Vincent Cabeli, Jean Ogier du Terrail, Alexey Rukhovich + 6 more
The development of climate-resilient crops would be greatly accelerated by models able to reason directly over plant genomic sequences and to pinpoint trait-associated regions or loci. Anticipating the impact of DNA base changes (variants) remains challenging, and understanding regulatory mechanisms is still an active…
Rupsha Panda, James A. Brissenden, Teresa Scerbak, Erin Proctor + 4 more
Parkinson’s disease is a neurodegenerative disorder with characteristic motor deficits of bradykinesia and impaired coordination, and non-motor deficits affecting cognitive abilities such as attention and executive functions. Recent evidence suggests that some canonical motor deficits in Parkinson’s disease (e.g.…
Daniel Büchel, Stefan J. Blaschke, Lisa Krampe, Victoria Prockl + 2 more
Background Persistent postconcussive symptoms (PPCS) affect approximately 30% of individuals following mild traumatic brain injury, resulting in prolonged sensorimotor and cognitive disruptions. While traditional assessments focus on isolated subfunctions, they often fail to capture the complex integration required for…
Wenbin Li, Rui Fan, Kun Xie, Jiehua Zhong + 12 more
EV-miRNAs are promising gastric cancer (GC) biomarkers for early diagnosis, yet their clinical application is limited by major detection challenges arising from the low abundance and high sequence homology of EV-miRNAs. Herein, we developed a dual-mode platform for sensitive EV-miRNA in situ profiling based on…