15 papers · ranked by Valyu relevance
Francisca Guzmán-Lastra, Hartmut Löwen, Arnold J. T. M. Mathijssen
Biological activity is often highly concentrated on surfaces, across the scales from molecular motors and ciliary arrays to sessile and motile organisms. These ‘active carpets’ locally inject energy into their surrounding fluid. Whereas Fick’s laws of diffusion are established near equilibrium, it is unclear how to…
Yann Lanoiselée, Nicolas Moutal, Denis S. Grebenkov
Most biochemical reactions in living cells rely on diffusive search for target molecules or regions in a heterogeneous overcrowded cytoplasmic medium. Rapid rearrangements of the medium constantly change the effective diffusivity felt locally by a diffusing particle and thus impact the distribution of the first-passage…
W. He, H. Song, Y. Su, L. Geng + 3 more
'P. Tong'] The Brownian motion of molecules at thermal equilibrium usually has a finite correlation time and will eventually be randomized after a long delay time, so that their displacement follows the Gaussian statistics. This is true even when the molecules have experienced a complex environment with a finite…
Hye Jin Park, Chaitanya S. Gokhale
Spatial patterns are ubiquitous across different scales of organization in ecological systems. Animal coat pattern, spatial organization of insect colonies and vegetation in arid areas are prominent examples from such diverse ecologies. Typically, pattern formation has been described by reaction-diffusion equations…
Mayumi Hamada, Pietro de Anna
Molecular diffusion in liquids is a key process in numerous systems: it is often the reaction rate limiting factor in biological or chemical reaction. Molecular diffusion has been recognized as the ultimate mechanism by which substances concentration get homogenized and, thus, their mixing and dilution occur. Here, we…
Raffaele Pastore, Antonio Coniglio, Massimo Pica Ciamarra
One of the most controversial hypotheses for explaining the heterogeneous dynamics of glasses postulates the temporary coexistence of two phases characterized by a high and by a low diffusivity. In this scenario, two phases with different diffusivities coexist for a time of the order of the relaxation time and mix…
Tadeusz Kosztołowicz, Aldona Dutkiewicz, Katarzyna D. Lewandowska
Normal and anomalous diffusion processes are characterized by the time evolution of the mean square displacement of a diffusing molecule $σ2(t)$. When $σ2(t)$ is a power function of time, the process is described by a fractional subdiffusion, fractional superdiffusion or normal diffusion equation. However, for other…
Lars Hubatsch, Louise M Jawerth, Celina Love, Jonathan Bauermann + 6 more
'TY Dora Tang' 'Stefano Bo' 'Anthony A Hyman' 'Christoph A Weber' 'Rohit V Pappu' 'José D Faraldo-Gómez'] Key processes of biological condensates are diffusion and material exchange with their environment. Experimentally, diffusive dynamics are typically probed via fluorescent labels. However, to date, a physics-based…
Stephen Smith, Claudia Cianci, Ramon Grima
It is now well established that cell interiors are significantly crowded by macromolecules, which impede diffusion and enhance binding rates. However, it is not fully appreciated that levels of crowding are heterogeneous, and can vary substantially between subcellular regions. In this article, starting from a…
Kine Ødegård Hanssen, Anders Malthe-Sørenssen
Perineuronal nets (PNNs) are mesh-like extracellular matrix structures that wrap around certain neurons in the central nervous system. They are hypothesized to stabilize memories in the brain and act as a barrier between cell and extracellular space. As a means to study the impact of PNNs on diffusion, the nets were…
Ying-Hua Chu, Yi-Cheng Hsu, Fa-Hsuan Lin
Field probes are miniature receiver coils with localized NMR-active samples inside. They are useful in monitoring magnetic field. This information can be used to improve magnetic resonance image quality. While field probes are coupled to each other marginally in most applications, this coupling can cause incorrect…
Benjamin A. Dalton, Ivo F. Sbalzarini, Itsuo Hanasaki
We develop a theoretical foundation for a time-series analysis method suitable for revealing the spectrum of diffusion coefficients in mixed Brownian systems, for which no prior knowledge of particle distinction is required. This method is directly relevant for particle tracking in biological systems, in which…
Mohammad S. Safari, Ryan Poling-Skutvik, Peter G. Vekilov, Jacinta C. Conrad
'Jacinta C. Conrad'] Research tasks in microgravity include monitoring the dynamics of constituents of varying size and mobility in processes such as aggregation, phase separation, or self-assembly. We use differential dynamic microscopy, a method readily implemented with equipment available on the International Space…
Hung-Yi Liu, Chien-Chi Lin
Hydrogels with spatiotemporally tunable mechanical properties have been increasingly employed for studying the impact of tissue mechanics on cell fate processes. These dynamic hydrogels are particularly suitable for recapitulating the temporal stiffening of a tumor microenvironment. To this end, we have reported an…
Vlad Elgart, Jia-Ren Lin, Joseph Loscalzo, Turkan Haliloglu
The physiochemical determinants of drug-target interactions in the microenvironment of the cell are complex and generally not defined by simple diffusion and intrinsic chemical reactivity. Non-specific interactions of drugs and macromolecules in cells are rarely considered formally in assessing pharmacodynamics. Here…