12 papers · ranked by Valyu relevance
Chenfei Ye, Jiahui Shi, Jiliang Fang, Tao Wu + 3 more
4## Discussion This study revealed striking, opposing alterations in the temporal dynamics of unimodal network-dominant brain states in PD and PSP: while PD patients exhibited reduced fraction occurrence in this state, PSP patients showed a clear increase. Notably, these findings represent the first direct evidence…
Jeffrey D. Walker, Paul Aparicio, Shreya Saxena, Nicholas G. Hatsopoulos + 1 more
The ability to record neural populations during natural behavior now allows us to ask whether canonical motor-cortical dynamics, defined largely in constrained reaches to static targets, also organize self-paced, feedback-rich actions that require continuous correction. We recorded sensorimotor cortex in marmosets…
Sheng Wang, Xiaoyong Duan, Yulin Zou, Jianxiong Gui
Title: Graphical abstract
Chiara Catalano, Deniz Ozturk, Maria Bastron, Alessandra Zerillo + 3 more
To develop a fully coupled, patient-specific fluid-structure interaction (FSI) framework for quantitative assessment of post-transcatheter aortic valve implantation (TAVI) hemodynamics and valve biomechanics, and to compare selected simulation-derived hemodynamic indices with post-procedural echocardiographic…
Henrique Reis Aguiar, Matthias H. Hennig
Predictive coding is a powerful normative framework for understanding cortical computation, but it is still an open question how biologically plausible networks with local plasticity support predictive inference and representation learning. In this work we show that a recurrent excitatory-inhibitory circuit with purely…
Tie-Qiang Mao, Xiaoyun Yang, Zhi-Cong He, Jiawen Yang + 6 more
Complete ammonia oxidizers (comammox) are widespread nitrifiers that can dominate ammonia oxidation in diverse environments by efficiently converting ammonia to nitrate within a single cell, yet the molecular basis distinguishing their ammonia monooxygenase (AMO) from those of canonical bacterial AMO remains…
Guangzheng Weng, Danfei Zhu, Yufei Zhao, Patrick C Martin + 4 more
Single-cell foundation models are increasingly adopted for downstream applications such as cell-type prediction. However, these predictions are often utilized without assessing their reliability, or by relying on a simple cutoff applied to the maximum softmax probability (MSP) derived from the classifier. This raises a…
M. Todisco, F. Boskovic, A. Jain
RNA structure can be predicted from sequence in dilute solution, but these predictions often fail in cells. Many cellular RNAs keep their in vitro folds, whereas others are substantially less structured. We combined single-molecule FRET with Xenopus oocyte extract to measure RNA folding and duplex formation under…
Robert M. Hechler, Tianna Peller, Marie-Josée Fortin, Martin Krkosek
Population fluctuations are now empirically recognized to be nonlinear, but the governing attractors are poorly understood. Here we show that population dynamics of 457 marine fish stocks from 121 species worldwide are governed by a single attractor that partitions into three archetypes reflecting top predators…
Zichao Jin, Jiaoru Wang, Wenjiang Huang, Jingcheng Zhang + 2 more
Accurate, reliable, large-scale disease predictions are essential to ensure rice production. Existing disease prediction models often face a trade-off between interpretability and predictive capability, necessitating the integration of mechanistic knowledge and data-driven learning within a modelling framework.…
Amarsinh R. Mainak, Prabhakar A. Chandanwale, Fatemah M. Al-Dousari, Aabid Hamid + 6 more
In recent luminescent materials research, the development of multifunctional aggregation induced enhanced emission (AIEE)-active molecules through simple and efficient synthetic routes has attracted considerable attention. In this study, a new fluorescence-active organic sensor is synthesized via a straightforward…
Raphael Mostov, Greyson Lewis, Gabriel Sturm, Wallace F. Marshall
This paper addresses the increasing need for comprehensive mathematical descriptions of cell organization by examining the algebraic structure of mitochondrial network dynamics. Mitochondria are cellular structures involved in metabolism that take the form of a network of membrane-based tubes that undergo continuous…