27 papers · ranked by Valyu relevance
Agata Mrozek, Tomasz Strek, Theodore E. Matikas
In this paper, a novel auxetic structure with rotating squares with holes is investigated. The unit cell of the structure consists of four units in the shape of a square with cut corners and holes. Finally, the structure represents a kind of modified auxetic structure made of rotating squares with holes or sheets of…
Sajid Ali, Muhammad A. Hawwa, Fei Wang
This study focuses on the nonlinear vibration of a small-size beam hosted in a high-speed moving structure. The equation of the beam’s motion is derived using the coordinate transformation. The small-size effect is introduced by applying the modified coupled stress theory. The equation of motion involves quadratic and…
Samrat Mukhopadhyay, Rashik Ahmed, Julie D. Forman-Kay
The spatial and temporal organization of interactions between proteins underlie the regulation of most cellular processes. The requirement for such interactions to be specific predisposes a view that protein-protein interactions are relatively static and are formed through the stable complementarity of the interacting…
Authors not listed
Active assembly of matter is a defining trait of living systems, enabling the creation of far-from-equilibrium materials essential for the functionality of life. This is achieved through energy-dissipative, multi-step processes facilitated by various biomolecular agents for chemical and mechanical assembly of matter.…
Zhenwei Luo, Yiqiu Zhang, Gang Xu, Qinghua Wang + 1 more
Cryo-electron microscopy (cryo-EM) datasets preserves a wide range of structural heterogeneities in macromolecules, arising from both large-scale dynamics and compositional changes. The deep learning framework OPUS-DSD has been developed to characterize the structural heterogeneities in cryo-EM data. However, different…
Malina K. Iwanski, Lukas C. Kapitein
Microtubules, one of the major components of the cytoskeleton, play a crucial role during many aspects of neuronal development and function, such as neuronal polarization and axon outgrowth. Consequently, the microtubule cytoskeleton has been implicated in many neurodevelopmental and neurodegenerative disorders. The…
Zeyu Yang, Steve Marston, ian gould
Phosphorylation of cardiac muscle troponin I by protein kinase A enhances troponin regulatory dynamics and is an essential part of the’ flight or fight’ response to adrenaline. Elucidating how phosphorylation at serines 22 and 23 modulates structural dynamics has been difficult as key regulatory segments of troponin…
Haohao Bi, Wenjie Li, Liuyun Wang, Bo Wang + 2 more
Thin film/substrate structures based on the principle of buckling mechanics exhibit both excellent stretchability and mechanical stability, and they have been recognized as a critical configuration in the design of flexible electronic devices. During application, flexible electronic devices are usually subjected to…
Wibke Schumann, Birgit Strodel
Dynamin superfamily proteins are mechanochemical GTPases that operate in highly oligomeric and highly cooperative superstructures to deform lipid membranes. It is known from the structures of a bacterial dynamin-like protein (BDLP) that binding of GTP and association of BDLP with lipids causes a transition from closed…
Kristy Rochon, Brianna L. Bauer, Nathaniel A. Roethler, Yuli Buckley + 7 more
Mitochondrial fission is crucial for distributing cellular energy throughout cells and for isolating damaged regions of the organelle that are targeted for degradation. This multistep process is initiated by the enhanced recruitment and oligomerization of dynamin-related protein 1 (Drp1) at the surface of mitochondria.…
Martina Crippa, Claudio Perego, Anna de Marco, Giovanni M. Pavan
Supramolecular polymers are composed of monomers that self-assemble non-covalently, generating distributions of monodimensional fibres in continuous communication with each other and with the surrounding solution. Fibres, exchanging molecular species, and external environment constitute a sole complex system, which…
Fabian Späth, Michele Stasi, Héctor Soria-Carrera, Judit Sastre + 2 more
Dynamic combinatorial chemistry (DCC) creates libraries of molecules that are constantly interchanging in a dynamic combinatorial library. When a library member self-assembles, it can displace the equilibria, leading to emergent phenomena like its selection or even its replication. However, such dynamic combinatorial…
Singh, Pradeep, Rushikesh, Mudasani + 4 more
We develop a unified, dynamical-systems narrative of the universe that traces a continuous chain of structure formation from the Big Bang to contemporary human societies and their artificial learning systems. Rather than treating cosmology, astrophysics, geophysics, biology, cognition, and machine intelligence as…
Haoyu Zhang, Wentao Zhang, Hao Miao, Xinke Jiang + 2 more
'Yifan Zhang'] Spatio-Temporal Graph Neural Networks (STGNNs) have emerged as a powerful tool for modeling dynamic graph-structured data across diverse domains. However, they often fail to generalize in Spatio-Temporal Out-of-Distribution (STOOD) scenarios, where both temporal dynamics and spatial structures evolve…
Xiaohua Lu, Leshanshui Yang
In this paper, we explore different approaches to anomaly detection on dynamic knowledge graphs, specifically in a microservices environment for Kubernetes applications. Our approach explores three dynamic knowledge graph representations: sequential data, one-hop graph structure, and two-hop graph structure, with each…
Anelise N. Hutson, Kristy Rochon, Jason A. Mears
Dynamin superfamily proteins (DSPs) are large GTPases that play crucial roles in membrane remodeling processes, including vesicle uptake, mitochondrial fission, and opposing fusion events. Among them, dynamin and dynamin-related protein 1 (Drp1) share a conserved domain architecture, yet exhibit unique structural and…
Hao Wu, Haomin Wen, Guibin Zhang, Yutong Xia + 4 more
Deep learning has revolutionized spatio-temporal (ST) forecasting, demonstrating remarkable proficiency in distilling valuable insights from extensive ST datasets (e.g., human mobility [29, 51], precipitation [5, 60], frame dynamics [23, 50], and meteorology [30, 52]). In recent years, the widespread deployment of…
Arslan Hameed
Human epidermal growth factor receptor 2 (HER2) is a transmembrane tyrosine kinase receptor that is overexpressed in many types of cancer, including breast cancer. HER2 overexpression is associated with poor prognosis and resistance to therapy. Therefore, HER2 is a promising target for cancer therapy. In this study, we…
Pablo Sartori, Stanislas Leibler
One of the tenets of molecular biology is that dynamical transitions between three dimensional structures largely determine the function of individual proteins, as well as multi-protein assemblies. Therefore, it seems only natural that evolutionary analysis of proteins, presently based mainly on their primary sequence…
Keerti Singh, Thomas J. Pucadyil
Membranes are fundamental to biological systems as they serve as barriers to compartmentalize the cell and its cytoplasm. They are constantly remodeled in shape and composition during the formation and maintenance of organelles. The large GTPase dynamins are well characterized for membrane shape remodeling in…
Wibke Schumann, Jennifer Loschwitz, Jens Reiners, Daniel Degrandi + 5 more
Guanylate binding proteins (GBPs) are interferon-γ-activated large GTPases, effective against intracellular pathogens like Toxoplasma gondii. Their host-protective functions require oligomerization, however, the oligomer structures have not been completely resolved yet. Here, we provide dimer models for hGBP1 and the…
Cindy Ng, Anirban Samanta, Ole Aalund Mandrup, Emily Tsang + 3 more
The folding of double-stranded DNA around histones is a central mechanism in eukaryotic cells for compacting the genetic information into chromosomes. Very few artificial methods are available for controlling the shape of dsDNA at any level, whereas several artificial methods have been developed to efficiently organize…
Marcin Konopka, Lau Halgreen, Anca-Elena Dascalu, Matúš Chvojka + 1 more
Stimuli-responsive transmembrane ion transport has become a prominent area of research due to its fundamental importance in cellular processes and potential therapeutic applications. Commonly used stimuli include pH, light, and reduction or oxidation agents. This paper presents the use of dynamic covalent chemistry…
Simone Martino, Matteo Becchi, Andrew Tarzia, Daniele Rapetti + 1 more
The study of complex many-body systems via analysis of the trajectories of the units that dynamically move and interact within them is a non-trivial task. The workflow for extracting meaningful information from the raw trajectory data is often composed of a series of interconnected steps, such as, (i) identifying and…
Chao Wang, Li Wan, Tifan Xiong, Yuanlong Xie + 3 more
'Jianwan Ding' 'Liping Chen'] Abstract: Structural analysis is a method for verifying equation-oriented models in the design of industrial systems. Existing structural analysis methods need flattening of the hierarchical models into an equation system for analysis. However, the large-scale equations in complex models…
Authors not listed
RNA molecules fold into complex three-dimensional structures that determine their function. A wide range of mathematical frameworks, such as chord diagrams, fatgraphs, and context-free grammars, have been used to represent these structures; however, these models have largely been developed from mathematical motivations…
Haokui Xu, Jifan Zhou, Mowei Shen, John Parkinson
Human vision is remarkably good at recovering the latent hierarchical structure of dynamic scenes. Here, we explore how visual attention operates with this hierarchical motion representation. The way in which attention responds to surface physical features has been extensively explored. However, we know little about…