14 papers · ranked by Valyu relevance
Veronika Koren, Simone Blanco Malerba, Tilo Schwalger, Stefano Panzeri
The principle of efficient coding posits that sensory cortical networks are designed to encode maximal sensory information with minimal metabolic cost. Despite the major influence of efficient coding in neuroscience, it has remained unclear whether fundamental empirical properties of neural network activity can be…
Tianhe Wang, Yifan Fang, David Whitney
A paramount challenge for the brain is to precisely model the world and control behavior within the confines of limited encoding capacities. Efficient coding theory posits a unified framework for understanding how neural systems enhance encoding accuracy by tuning to environmental statistics. While this theory has been…
Saurabh Bedi, Gilles de Hollander, Maximilian Harl, Christian C. Ruff
To act effectively, the brain must transform information through a chain of processing stages, from sensing the environment, to evaluating options, to selecting actions. Because neural resources are limited, each stage should represent information efficiently. Yet efficient coding has been studied almost exclusively in…
Veronika Koren, Alan J. Emanuel, Stefano Panzeri
How do biological neural systems efficiently encode, transform and propagate information between the sensory periphery and the sensory cortex about sensory features evolving at different time scales? Are these computations efficient in normative information processing terms? While previous work has suggested that…
William Dorrell, Peter E. Latham, Timothy E. J. Behrens, James C. R. Whittington
The efficient coding hypothesis presents a compelling success story for theoretical and systems neuroscience. It marshals a unifying idea, that neural codes can be understood as efficient encodings of natural stimuli, to explain phenomena from across sensory systems, sometimes with exquisite precision. However, similar…
Fajia Sun, Long Qian
DNA has been pursued as a compelling medium for digital data storage during the past decade. While large-scale data storage and random access have been achieved in artificial DNA, the synthesis cost keeps hindering DNA data storage from popularizing into daily life. In this study, we proposed a more efficient paradigm…
Mingyi Huang, Wei Lin, Anna Wang Roe, Yuguo Yu
Understanding how cortical neurons use dynamic firing patterns to represent sensory signals is a central challenge in neuroscience. Decades of research have shown that cortical neuronal activities exhibit high variance, typically quantified by the coefficient of variation (CV), suggesting intrinsic randomness.…
Roland Wittler
To index or compare sequences efficiently, often k-mers, i.e., substrings of fixed length k, are used. For efficient indexing or storage, k-mers are often encoded as integers, e.g., applying some bijective mapping between all possible σ^k^ k-mers and the interval [0, σ^k^ −1], where σ is the alphabet size. In many…
Victor Quintanar-Zilinskas
Perceptual systems are constrained by their information transmission capacity. Accordingly, organismal strategies for compressing environmental information have been the subject of considerable study. The efficient coding model posits maximized mutual information between stimuli and their neural representation. The…
Ramy Khabbaz, Jérémy Mateos, Marc Antonini, Serge Kas Hanna
The biochemical processes underlying DNA data storage, including synthesis, amplification, and sequencing, are inherently noisy. Consequently, base-level insertion, deletion, and substitution (IDS) errors, as well as sequence-level dropouts, occur and pose major challenges for reliable data retrieval. Here we introduce…
Jia Lu, Ryan Tsoi, Nan Luo, Yuanchi Ha + 8 more
Dynamical systems often generate distinct outputs according to different initial conditions, and one can infer the corresponding input configuration given an output. This property captures the essence of information encoding and decoding. Here, we demonstrate the use of self-organized patterns, combined with machine…
Jingcheng Zhang, Lei Chen, Jinlin Sun, Shumin Li + 5 more
DNA has emerged as a compelling archival storage medium, offering unprecedented information density and millennia-scale durability. Despite its promise, DNA-based data storage faces critical challenges due to error-prone processes during DNA synthesis, storage, and sequencing. In this study, we introduce Gungnir, a…
Michael Yarus
Standard Genetic Code (SGC) evolution is quantitatively modeled in computed ‘worlds’ containing up to 2000 independent coding ‘environments’. Environments can host multiple codes that may fuse or divide, with division yielding identical descendants. Code division may be selected - sophisticated gene products could be…
Kevin D. Volkel, Paul W. Hook, Albert Keung, Winston Timp + 1 more
As nanopore technology reaches ever higher throughput and accuracy, it becomes an increasingly viable candidate for reading out DNA data storage. Nanopore sequencing offers considerable flexibility by allowing long reads, real-time signal analysis, and the ability to read both DNA and RNA. We need flexible and…