6 papers · ranked by Valyu relevance
Sylvain Christin, Nicolas Lecomte
Biological and ecological models are being increasingly used to explain the natural world. Model creation is an iterative process requiring two steps: training and evaluating the models. However, this process can become complex when multiple models are trained and evaluated at the same time. Besides, development steps…
Nadine S. Kurz, Kevin Kornrumpf, Martin Stoves, Jürgen Dönitz
Fragmented bioinformatics tools compels researchers and clinicians to resort to error-prone manual pipelines. The success of precision medicine depends largely on the efficient interpretation of genetic variants and the selection of highly effective targeted therapies. However, the success of precision medicine and…
Chen Chen, Yuanyuan Liu, Lei Wang, Jingyi Sai + 8 more
With the rapid accumulation of diverse omics datasets, achieving efficient management and integrative analysis of plant multi-omics data remains a major challenge. Conventional solutions rely on constructing web-based databases, which often demand substantial programming expertise and long-term financial support. To…
James Wenhan Li, Ravi Bandaru, Yaping Liu
Cell-free DNA (cfDNA) fragmentation pattern represents a promising non-invasive biomarker for disease diagnosis and prognosis. Numerous fragmentation features, such as end motif and window protection score (WPS), have been characterized in cfDNA genomic sequencing. However, the analytical tools developed in these…
Ayush Pandey, Inigo Incer, Alberto Sangiovanni-Vincentelli, Richard M. Murray
We provide a new perspective on using formal methods to model specifications and synthesize implementations for the design of biological circuits. In synthetic biology, design objectives are rarely described formally. We present an assume-guarantee contract framework to describe biological circuit design objectives as…
Andreas Evers, Shipra Malhotra, Wolf-Guido Bolick, Ahmad Najafian + 7 more
To select the most promising screening hits from antibody and VHH display campaigns for subsequent in-depth profiling and optimization, it is highly desirable to assess and select sequences on properties beyond only their binding signals from the sorting process. In addition, developability risk criteria, sequence…