12 papers · ranked by Valyu relevance
Yunfei Liang, Fanyi Meng, Hongwei Sun, Hongyan Shi + 2 more
Title: SUMMARY Chilling stress severely restricts tomato cultivation and productivity, yet the mechanisms by which a single regulator integrates photosynthetic efficiency, developmental progression, and chilling tolerance remain to be elucidated. Here, we characterized SlBBX19, a chilling-inducible B-box transcription…
Fei-Fei Cheng, Hao Mou, Zhenyu Liu, Chang-Jun Zhang + 7 more
Title: Significance Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss among older adults and is projected to affect approximately 288 million people worldwide by 2040. Identifying the genes and cellular mechanisms underlying established AMD risk loci is essential for…
Jingxian Chen, Sharan Surya, Rojin Chitrakar, Jenna R. Valley + 2 more
Starvation profoundly impacts development, but how different tissues respond to starvation is unclear. We generated a cellular atlas of gene expression in fed and starved C. elegans L1 larvae. We identified 79 cell types in both conditions, and we detected ∼98% of protein-coding genes, 44% of which were differentially…
Yasmin H. Ramadan, Curtis M. Loer, Hyunsoo Yim, Luke T. Geiger + 7 more
The evolution of brains is subject to investigation in many different animal groups, each offering unique advantages to advance our understanding of the cellular, molecular and regulatory substrates of evolutionary change. Here, we use two nematode species, C. elegans and P. pacificus, separated by more than 200…
Øyvind Sætren Gulbrandsen, Cathrine Brekke, Marie-Odile Baudement, Tan Thi Nguyen + 3 more
Meiotic recombination in many vertebrate lineages is directed to genomic regions by the DNA-binding protein PRDM9. To date, PRDM9 research has focused primarily on mammals, and its role in recombination localization has only recently been established in salmonids. PRDM9 binding specificity is determined by a tandemly…
Zhi Yang, Tingting Luo, Yimin Zhang, Yuhua Sun + 2 more
The ricefield eel (Monopterus albus), an economically important aquaculture species in China, is a freshwater teleost fish that exhibits protogynous hermaphroditism. Although progress has been made in understanding the sex determination and differentiation of this species, the underlying mechanisms remain unclear.…
Longsheng Zhang, Ning Liang
2.11### Statistical Methods For measurement indicators conforming to gaussian distribution, they were described using mean ± standard deviation (x ± s) and contrasted using independent samples t-tests. If measurement data did not fit normal distribution, described with median (IQR) and compared using rank-sum tests.…
Eli J. Costa, Carolina Rios-Martinez, Cecelia J. Andrews, James E. Ferrell + 1 more
Quantitatively relating transcription factor (TF) input to gene expression output is central to understanding mammalian gene regulation and essential for designing predictable synthetic expression systems. However, even minimal synthetic systems often exhibit unexplained behaviors. In a widely used inducible mammalian…
Ajay Kumar Danga, Alessio Colantoni, Nicola Pomella, Nerea Ruiz Blanes + 5 more
Autism spectrum disorder (ASD) shows a strong male bias (∼4:1). CHD8, a frequently mutated ASD gene, regulates neuronal development and Xist regulation in X-chromosome inactivation (XCI). However, its role in female neurodevelopment remains poorly understood due to the predominance of male-derived or sex-agnostic…
Yusuke Tsuruta, Hirotaka Inoue, Kenta Hagiwara, Charles S Hoffman + 1 more
An appropriate transcriptional response to external stresses is crucial for all organisms. Gene expression is regulated by transcription factors (TFs) binding to specific DNA cis-elements. However, how individual TFs achieve stress-specific binding remains elusive. Here we examine the molecular basis of the…
Tunç Dabak, Jeffrey D. Lozier, Cecil Smith, Brandon Meadows + 2 more
Several species of North American bumble bees spanning the Pacific Coastal and Rocky Mountain regions converge onto distinct mimetic abdominal colour forms for each region by switching abdominal coloration from black to red. Previous genome-wide association studies (GWAS) of red and black transitions in two mimics…
Stan Oome, Mohammad Ghanbari
Allelic heterogeneity is a term from genetics which means that alleles that differ in primary sequence can have a similar phenotypic outcome. In other words, they are functional equivalents, and they naturally appear through convergent evolution under selection. Current GWAS has trouble detecting these instances, as…