15 papers · ranked by Valyu relevance
Ryo Kuroiwa, Edward Lam
Authors are encouraged to submit new papers to INFORMS journals by means of a style file template, which includes the journal title. However, use of a template does not certify that the paper has been accepted for publication in the named journal. INFORMS journal templates are for the exclusive purpose of submitting to…
Clement Francois, Gabriela Gawlik, Jorge Mestre-Ferrandiz, Adrian Pana + 3 more
'Adrian Pana' 'Julian Perelman' 'John Yfantopoulos' 'Steven Simoens'] Background: Price erosion of generic medicines over time as a result of existing pricing policies in combination with increasing operational costs of these products due to high inflation, undermine long-term sustainable competition in European…
Asunción Jiménez-Cordero, Salvador Pineda, Juan M. Morales
Problem Authors: ['Asunción Jiménez-Cordero' 'Salvador Pineda' 'Juan M. Morales'] The Rank Pricing Problem (RPP) is a challenging bilevel optimization problem with binary variables whose objective is to determine the optimal pricing strategy for a set of products to maximize the total benefit, given that customer…
Daniel G. Rasines, Roi Naveiro, David Rı́os Insua, Simón Rodríguez Santana
'Simón Rodríguez Santana'] Pricing decisions stand out as one of the most critical tasks a company faces, particularly in today's digital economy. As with other business decision-making problems, pricing unfolds in a highly competitive and uncertain environment. Traditional analyses in this area have heavily relied on…
Qian Shao, Tien Mai, Shih-Fen Cheng
We consider a dynamic pricing problem in network revenue management where customer behavior is predicted by a choice model, i.e., the multinomial logit (MNL) model. The problem, even in the static setting (i.e., customer demand remains unchanged over time), is highly non-concave in prices. Existing studies mostly rely…
Serena Perna, Agnese Cangini, Roberto Marini, Maria Alessandra Guerrizio + 3 more
'Maria Alessandra Guerrizio' 'Roberto Da Cas' 'Giuseppe Traversa' 'Francesco Trotta'] Introduction The aim of the study was to evaluate, in a regulated generics market, the effect of the number of manufacturers of generic drugs on the amplitude of off-patent products price reduction and the price evolution of…
Antonio J. Trujillo, Jose C. Gutierrez, Emmanuel E. Garcia Morales, Mariana Socal + 2 more
Background Well-functioning competitive markets are key to controlling generic drug prices. This is important since over 90% of all drugs sold in the US are generics. Recently, there have been examples of large price increases in the generic market. Methods This paper examines price trajectories for generic drugs using…
Chanmi Park, Dong-Sook Kim, Inmyung Song, Ebenezer Wiafe
Containing the same active ingredient, generic drugs are considered the bioequivalent and lower-priced alternatives to the originator brand-name drug . Many countries that are burdened with skyrocketing drug expenditures have implemented measures to promote the use of generic drugs in many countries . Pharmaceutical…
Quan Wang, Siqi Liu, Zhijie Nie, Zheng Zhu + 5 more
'Xia Wei' 'Li Yang' 'Xiaolin Wei'] Background Generic drugs have been seen as a potentially powerful way to alleviate the financial burden on patients and health care systems. Two strategies for achieving rational prices of generic drugs are tiered pricing framework and pooled purchasing power. We compare the…
Da Hye Lee, Jung-Ae Kim, Kyung Min Lim, Ji Won Jung + 3 more
'Yoon-A Jang' 'Jong Hyuk Lee'] Introduction While many countries have successfully promoted generic drug use, South Korea faces challenges with low utilization and high expenditure shares, despite various policy reforms. This study aimed to evaluate the effectiveness of generic drug policies in South Korea, by…
Murat Cihan Sorkun, Baptiste Saliou, Süleyman Er
The open-access movement in chemistry has led to a surge in publicly accessible data repositories such as PubChem and ChemSpider, housing more than 100 million chemical compounds. These repositories are invaluable for large-scale virtual screening but lack crucial pricing information, a vital economic aspect…
Tom Marty, Léo Boisvert, Tristan François, Pierre Tessier + 3 more
'Louis Gautier' 'Louis-Martin Rousseau' 'Quentin Cappart'] Constraint programming is known for being an efficient approach to solving combinatorial problems. Important design choices in a solver are the branching heuristics, designed to lead the search to the best solutions in a minimum amount of time. However…
Ruben Sanchez-Garcia, Dávid Havasi, Gergely Takács, Matthew C. Robinson + 3 more
Compound availability is a critical property for design prioritization across the drug discovery pipeline. Historically, and despite their multiple limitations, compound-oriented synthetic accessibility scores have been used as proxies for this problem. However, the size of the catalogues of commercially available…
Tom Marty, Tristan François, Pierre Tessier, Louis Gauthier + 2 more
'Quentin Cappart' 'Louis-Martin Rousseau'] Constraint programming is known for being an efficient approach to solving combinatorial problems. Important design choices in a solver are the branching heuristics, designed to lead the search to the best solutions in a minimum amount of time. However, developing these…
Matthijs van Veelen
The generality of Hamilton’s rule^1,2^ is much debated^3–14^. In this paper, I show that this debate can be resolved by constructing a general version of Hamilton’s rule, which allows for a large variety of ways in which the fitness of an individual can depend on the social behaviour of oneself and of others. For this…