14 papers · ranked by Valyu relevance
Fabien Campagne, William ER Digan, Manuele Simi
Data analysis tools have become essential to the study of biology. Tools available today were constructed with layers of technology developed over decades. Here, we explain how some of the principles used to develop this technology are sub-optimal for the construction of data analysis tools for biologists. In contrast…
X. Michalet
Fluorescence Lifetime Imaging (FLI) is a technique recording the temporal decay of fluorescence emission at every pixel of an image. Analyzing the information embedded in FLI dataset requires either fitting the decay to a predefined model using nonlinear least-square fit or maximum likelihood estimation, or projecting…
Tom C. Freeman, Sebastian Horsewell, Anirudh Patir, Josh Harling-Lee + 5 more
Quantitative and qualitative data derived from the analysis of genomes, genes, proteins or metabolites from tissue or cells are currently generated in huge volumes during biomedical research. Graphia is an open-source platform created for the graph-based analysis of such complex data, e.g. transcriptomics, proteomics…
Jason P. Kurs, Manuele Simi, Fabien Campagne
Computational workflows and pipelines are often created to automate series of processing steps. For instance, workflows enable one to standardize analysis for large projects or core facilities, but are also useful for individual biologists who need to perform repetitive data processing. Some workflow systems, designed…
Peter A. Andrews, Joan Alexander, Jude Kendall, Michael Wigler
Effective and efficient exploration of numeric data and annotations as a function of genomic position requires specialized software. We present G-Graph, an interactive genomic scatter plot viewer. G-Graph stacks or tiles multiple data series in one graph using different colors and markers. It displays gene annotation…
Yann Spöri, Jean-François Flot
Haxe is a general purpose, object-oriented programming language supporting syntactic macros. The Haxe compiler is well known for its ability to translate the source code of Haxe programs into the source code of a variety of other programming languages including Java, C++, JavaScript and Python. Although Haxe is…
Robert Haase, Akanksha Jain, Stéphane Rigaud, Daniela Vorkel + 7 more
Modern life science relies heavily on fluorescent microscopy and subsequent quantitative bio-image analysis. The current rise of graphics processing units (GPUs) in the context of image processing enables batch processing large amounts of image data at unprecedented speed. In order to facilitate adoption of this…
Kari Lavikka, Jaana Oikkonen, Yilin Li, Taru Muranen + 9 more
Visualization is an indispensable facet of genomic data analysis. Despite the abundance of specialized visualization tools, there remains a distinct need for tailored solutions. However, their implementation typically requires extensive programming expertise from bioinformaticians and software developers, especially…
Run Zhou Ye, Christophe Noll, Gabriel Richard, Martin Lepage + 2 more
The advent of deep-learning has set new standards in an array of image translation applications. At present, the use of these methods often requires computer programming experience. Non-commercial programs with graphical interface usually do not allow users to fully customize their deep-learning pipeline. Therefore…
Muhammad Zain Butt, Rana Sheraz Ahmad, Eman Fatima, Muhammad Tahir ul Qamar
The application of Large Language Models (LLMs) for generating data visualizations through natural language interaction represents a promising advance in AI-assisted scientific analysis. However, existing LLM-based tools largely emphasize graph generation, while research workflows require not only visualization but…
Muhammed Khawatmi, Yoann Steux, Sadam Zourob, Heba Sailem
Intuitive visualisation of quantitative microscopy data is crucial for interpreting and discovering new patterns in complex bioimage data. Existing visualisation approaches, such as bar charts, scatter plots and heat maps, do not accommodate the complexity of visual information present in microscopy data. Here we…
Fawaz Dabbaghie
The representation of genomes and genomic sequences through graph structures has undergone a period of rapid development in recent years, particularly to accommodate the growing size of genome sequences that are being produced. Genome graphs have been employed extensively for a variety of purposes, including assembly…
Martina Paganin, Toma Tebaldi, Fabio Lauria, Gabriella Viero
The last decade has witnessed massive advancements in high-throughput techniques capable of producing quantifications of transcript and protein levels across time and space, and at high resolution. Yet, the large volume of big data available and the complexity of experimental designs hamper an easy understanding and…
Jouni Sirén, Benedict Paten
Pangenome graphs representing aligned genome assemblies are being shared in the text-based Graphical Fragment Assembly format. As the number of assemblies grows, there is a need for a file format that can store the highly repetitive data space-efficiently. We propose the GBZ file format based on data structures used in…