12 papers · ranked by Valyu relevance
Vera Valakh, Xiaoyue Aelita Zhu, Derek Wise, Stephen Van Hooser + 5 more
Healthy neuronal networks rely on homeostatic plasticity to maintain stable firing rates despite changing synaptic drive. These mechanisms, however, can themselves be destabilizing if activated inappropriately or excessively. For example, prolonged activity deprivation can lead to rebound hyperactivity and seizures.…
Xiuming Yuan, Sofía Puvogel, Jon-Ruben van Rhijn, Anna Esteve-Codina + 8 more
Mechanisms that underlie homeostatic plasticity have been extensively investigated at single-cell levels in animal models, but are less well understood at the network level. Here, we used microelectrode arrays to characterize neuronal networks following induction of homeostatic plasticity in human induced pluripotent…
Simón(e) D. Sun, Daniel Levenstein, Boxing Li, Nataniel Mandelberg + 7 more
Neurons use various forms of negative feedback to maintain their synaptic strengths within an operationally useful range. While this homeostatic plasticity is thought to distinctly counteract the destabilizing positive feedback of Hebbian plasticity, there is considerable overlap in the molecular components mediating…
Salomon Z. Muller, LF Abbott, Nathaniel B. Sawtell
Homeostatic (anti-Hebbian) forms of synaptic are effective at eliminating “prediction errors” that signal the differences between predicted and actual sensory input. However, such mechanisms appear to preclude the possibility of transmitting the resulting predictions to downstream circuits, severely limiting their…
Lisa A. McIlvried, John Smith Del Rosario, Melanie Y. Pullen, Andi Wangzhou + 7 more
In response to changes in activity induced by environmental cues, neurons in the central nervous system undergo homeostatic plasticity to sustain overall network function during abrupt changes in synaptic strengths. Homeostatic plasticity involves changes in synaptic scaling and regulation of intrinsic excitability.…
Christoph Miehl, Julijana Gjorgjieva
Synaptic changes underlie learning and memory formation in the brain. But synaptic plasticity of excitatory synapses on its own is unstable, leading to unlimited growth of synaptic strengths without additional homeostatic mechanisms. To control excitatory synaptic strengths we propose a novel form of synaptic…
Kunaal Joshi, Charles S. Wright, Karl F. Ziegler, Elizabeth M. Spiers + 4 more
We reconceptualize homeostasis from an inherently stochastic, intergenerational perspective. Here we use our SChemostat technology to directly record high-precision multigenerational trains of sizes of statistically identical non-interacting individual cells of Caulobacter crescentus in precisely controlled…
Kunaal Joshi, Karl F Ziegler, Shaswata Roy, Charles S Wright + 4 more
Do individual bacterial cells retain memories of the history of environmental conditions experienced in previous generations? Here we directly address this question through a synthesis of physics theory and high-precision experiments on statistically identical, non-interacting individual bacterial cells, which grow and…
Hanna Salman, Kuheli Biswas, Naama Brenner
Biological systems maintain homeostasis, ensuring stability in the face of internal and external perturbations and counteracting stochastic noise. Traditionally, this is understood through the lens of control mechanisms designed to offset deviations and maintain certain quantities near functionally desired set-points.…
João Luiz de Oliveira Madeira, Fernando Antoneli
Homeostasis, also known as adaptation, refers to the ability of a system to counteract persistent external disturbances and tightly control the output of a key observable. Existing studies on homeostasis in network dynamics have mainly focused on ‘perfect adaptation’ in deterministic single-input single-output networks…
Peter Ruoff
This paper presents an analysis of compensatory flux organizations in integral controllers, which are combined at the level of the controlled variable. Dependent on the controllers’ relative setpoints two types of compensatory flux regulations occur, which have been termed delegated and isolated control. In delegated…
Clemente F. Arias, Francisco J. Acosta, Federica Bertocchini, Cristina Fernández-Arias
In this work, we present a novel modeling framework for understanding the dynamics of homeostatic regulation. Inspired by engineering control theory, this framework incorporates unique features of biological systems. First, biological variables often play physiological roles, and taking this functional context into…