20 papers · ranked by Valyu relevance
Jintao Gu, Sukbin Lim, Abigail Morrison
Working memory is a core component of critical cognitive functions such as planning and decision-making. Persistent activity that lasts long after the stimulus offset has been considered a neural substrate for working memory. Attractor dynamics based on network interactions can successfully reproduce such persistent…
Huanwen Chen, Lijuan Xie, Yijun Wang, Hang Zhang
Metabolic energy can be used as a unifying principle to control neuronal activity. However, whether and how metabolic energy alone can determine the outcome of synaptic plasticity remains unclear. This study proposes a computational model of synaptic plasticity that is completely determined by energy. A simple…
Xiuming Yuan, Sofía Puvogel, Jon-Ruben van Rhijn, Anna Esteve-Codina + 8 more
Mechanisms that underlie homeostatic plasticity have been extensively investigated at single-cell levels in animal models, but are less well understood at the network level. Here, we used microelectrode arrays to characterize neuronal networks following induction of homeostatic plasticity in human induced pluripotent…
Ege T. Kavalali, Lisa M. Monteggia
Neuronal and synaptic plasticity are widely used terms in the field of psychiatry. However, cellular neurophysiologists have identified two broad classes of plasticity. Hebbian forms of plasticity alter synaptic strength in a synapse specific manner in the same direction of the initial conditioning stimulation. In…
Elisa Galliano, Tara Keck
Statistical learning, sensory-driven unsupervised learning of repeating patterns, must coexist with ongoing homeostatic plasticity that is responsible for the necessary balance of activity in the brain; however, the mechanisms that facilitate these interactions are not clear. While models of both statistical learning…
Simón(e) D. Sun, Daniel Levenstein, Boxing Li, Nataniel Mandelberg + 7 more
Neurons use various forms of negative feedback to maintain their synaptic strengths within an operationally useful range. While this homeostatic plasticity is thought to distinctly counteract the destabilizing positive feedback of Hebbian plasticity, there is considerable overlap in the molecular components mediating…
Vicky Zhu, R. A. Rosenbaum
The brain is believed to operate in part by making predictions about sensory stimuli and encoding deviations from these predictions in the activity of "prediction error neurons." This principle defines the widely influential theory of predictive coding. The precise circuitry and plasticity mechanisms through which…
Lior Bar, Lia Shalom, Jonathan Lezmy, Asher Peretz + 1 more
A large body of studies has investigated bidirectional homeostatic plasticity both in vitro and in vivo using numerous pharmacological manipulations of activity or behavioral paradigms. However, these experiments rarely explored in the same cellular system the bidirectionality of the plasticity and simultaneously on…
Lisa A. McIlvried, John Smith Del Rosario, Melanie Y. Pullen, Andi Wangzhou + 7 more
In response to changes in activity induced by environmental cues, neurons in the central nervous system undergo homeostatic plasticity to sustain overall network function during abrupt changes in synaptic strengths. Homeostatic plasticity involves changes in synaptic scaling and regulation of intrinsic excitability.…
Nima Dehghani
Examining individual components of cellular systems has been successful in uncovering molecular reactions and interactions. However, the challenge lies in integrating these components into a comprehensive system-scale map. This difficulty arises due to factors such as missing links (unknown variables), overlooked…
Tania Quintela-López, Jonathan Lezmy
Although the knowledge in the field is still sparse, recent literature suggests that homeostatic plasticity of axonal excitable sites may play a crucial role in the pathophysiology of AD. Axonal homeostatic adaptations that are triggered at the onset of the disease may be beneficial to counter network…
Yunduo Zhou, Bo Dong, Chang Li, Yuanchen Wang + 3 more
Homeostatic mechanisms play a crucial role in maintaining optimal functionality within the neural circuits of the brain. By regulating physiological and biochemical processes, these mechanisms ensure the stability of an organism's internal environment, enabling it to better adapt to external changes. Among these…
Kunaal Joshi, Charles S. Wright, Karl F. Ziegler, Elizabeth M. Spiers + 4 more
We reconceptualize homeostasis from an inherently stochastic, intergenerational perspective. Here we use our SChemostat technology to directly record high-precision multigenerational trains of sizes of statistically identical non-interacting individual cells of Caulobacter crescentus in precisely controlled…
Cian O’Donnell
Learning and memory relies on synapses changing their strengths in response to neural activity. However there is a substantial gap between the timescales of neural electrical dynamics (1—100 ms) and organism behaviour during learning (seconds—minutes). What mechanisms bridge this timescale gap? What are the…
Eddy Kwessi
Neural plasticity is fundamental to memory storage and retrieval in biological systems, yet existing models often fall short in addressing noise sensitivity and unbounded synaptic weight growth. This paper investigates the Allee-based nonlinear plasticity model, emphasizing its biologically inspired weight…
Peter Ruoff
This paper presents an analysis of compensatory flux organizations in integral controllers, which are combined at the level of the controlled variable. Dependent on the controllers’ relative setpoints two types of compensatory flux regulations occur, which have been termed delegated and isolated control. In delegated…
Weiping Wu, Shuaixin Fan, Xuan Wu, Lili Fang + 1 more
Transition metal catalysis has revolutionized modern synthetic chemistry for its diverse modes of coordination reactivity. However, this versatility in reactivity is also the predominant cause of catalyst deactivation, a persisting issue that can significantly compromise its synthetic value. Homeostatic catalysis, a…
Authors not listed
The therapeutic potential of cannabis remains constrained by persistent physiological side effects that limit both medical applications and user tolerability. This paper presents a theo- retical framework for addressing these limitations through coordinated multi-target pharma- cological intervention. By synthesizing…
Carley V. Cook, Ariel M. Lighty, Brenda J. Smith, Ashlee N. Ford Versypt
Bone remodeling is an essential physiological process in the adult skeleton. Due to the complex nature of this process, many mathematical models of bone remodeling have been developed. Each of these models has unique features, but they have underlying patterns. In this review, the authors highlight the important…
Authors not listed
Understanding how plants respond to dynamic and spatially variable stimuli is a key goal in plant sciences. Traditional imaging methods often involve a trade-off between environmental control and spatial resolution, limiting their ability to capture real-time responses in high resolution. Microfluidic technology…