3 papers · ranked by Valyu relevance
Ranjita Dutta Roy, Christian Rosenmund, Melanie I Stefan
The high-dose hook effect (also called prozone effect) refers to the observation that if a multivalent protein acts as a linker between two parts of a protein complex, then increasing the amount of linker protein in the mixture does not always increase the amount of fully formed complex. On the contrary, at a high…
Blaž Kociper, Alja Nike Kastrin, Katarina Miš, Pablo M Garcia-Roves + 10 more
Despite peer review, hundreds of biomedical articles contain errors due to identical abbreviations that refer to different proteins. This includes PDK1, denoting both pyruvate dehydrogenase kinase 1 and 3-phosphoinositide-dependent protein kinase 1. Our analysis shows that one-out-of-five articles with the term PDK1 on…
Matthew Shang, Eric Klavins, Gilbert Bernstein
Formalizing protocols used in wetlab biological research as programs improves reproducibility by making protocols replicable and standardized. However, existing protocol languages have limited capacity for codifying error sources and standardizing error handling. When protocols inevitably go wrong, debugging must still…