20 papers · ranked by Valyu relevance
Jarin Taslem Mourosi, Ayobami Awe, Wenzheng Guo, Himanshu Batra + 4 more
'Harrish Ganesh' 'Xiaorong Wu' 'Jingen Zhu' 'Alicja Wegrzyn'] Bacteriophages (phages), as natural antibacterial agents, are being rediscovered because of the growing threat of multi- and pan-drug-resistant bacterial pathogens globally. However, with an estimated 1031 phages on the planet, finding the right phage to…
James J. Bull, Holly A. Wichman, Stephen M. Krone
The host ranges of individual phages tend to be narrow, yet many applications of phages would benefit from expanded host ranges. Empirical methods have been developed to direct the evolution of phages to attack new strains, but the methods have not been evaluated or compared for their consequences. In particular, how…
Pavel B. Klimov, Qixin He
Multi-host parasites pose greater health risks to wildlife, livestock, and humans than single-host parasites, yet our understanding of how ecological and biological factors influence a parasite’s host range remains limited. Here, we assemble the largest and most complete dataset on permanently parasitic mammalian mites…
James J. Bull, Holly A. Wichman, Stephen M. Krone, Grzegorz Wegrzyn
Background: The host ranges of individual phages tend to be narrow, yet many applications of phages would benefit from expanded host ranges. Empirical methods have been developed to direct the evolution of phages to attack new strains, but the methods have not been evaluated or compared for their consequences. In…
Ka Mun Chung, Xiew Leng Liau, Swee Seong Tang, Gordana Maravić Vlahoviček + 1 more
'Gordana Maravić Vlahoviček' 'Branka Bedenić'] The rapid emergence of multidrug-resistant (MDR) bacteria in recent times has prompted the search for new and more potent antibiotics. Bacteriophages (commonly known as phages) are viruses that target and infect their bacterial hosts. As such, they are also a potential…
Taylor P. Andrews, Abbey Isaac, Siobain Duffy
RNA viruses frequently shift between infecting different hosts and emerge on novel hosts. Part of this evolutionary process can involve specialization, when viruses adapt to increase their fitness on a particular host, often at the expense of their ability to infect other hosts. This trajectory has the potential to…
Yang Shen, Keming Shi, Yu Chen, Rui Zhang + 2 more
Motivation: Bacteriophages (phages) are key regulators of bacterial populations and hold great promise for applications such as phage therapy, biocontrol, and industrial fermentation. The success of these applications depends on accurately determining phage host range, which is often specific at the strain level rather…
Clara Torres‐Barceló, Claudine Boyer, Julian R. Garneau, Stéphane Poussier + 2 more
'Stéphane Poussier' 'Isabelle Robène' 'Benoît Moury'] Title: ABSTRACT Phages are typically known for having a limited host range, targeting particular strains within a bacterial species, but accurately measuring their specificity remains challenging. Factors like the genetic diversity or population dynamics of host…
Céline Caseys, Daniel J. Kliebenstein
Diverse qualitative and quantitative genetic architectures can successfully influence fungal virulence and host range. To model the quantitative genetic architecture of a generalist pathogen with an extensive host range, we conducted a genome-wide association study (GWAS) of the virulence of Botrytis cinerea across…
Ritu Singh, Anna Jo Muhich, Cloe Tom, Jack McMillan + 4 more
How generalist pathogens infect phylogenetically diverse hosts remains a central question in plant-pathogen biology. In particular, the extent to which broad host range is enabled by genetic variation versus transcriptional plasticity is unclear. To investigate how variation and plasticity contribute to generalism, we…
Xuechun ‘May’ Wang, Julia Muller, Mya McDowell, David A. Rasmussen
The range of hosts a given virus can infect is widely presumed to be limited by tradeoffs in fitness between alternative hosts. These fitness tradeoffs may arise naturally due to antagonistic pleiotropy if mutations that increase fitness in one host tend to decrease fitness in alternate hosts. While antagonistic…
Cigdem Alkan, Gautier Brésard, Lise Frézal, Aurélien Richaud + 3 more
Antagonistic relationships such as host-virus interactions potentially lead to rapid evolution and specificity in interactions. The Orsay virus is so far the only horizontal virus naturally infecting the nematode C. elegans. In contrast, several related RNA viruses infect its congener C. briggsae, including Santeuil…
Anai Novoa, Ryan F. Hechinger
The lack of information concerning how parasitism maps onto host geographical distributions represents a striking gap in ecological knowledge. This knowledge gap limits our understanding of a wide range of phenomena, including the consequences of climate change-induced range shifts of both hosts and parasites. To help…
Nimesha Wickramasinghe, Mohamed Nabeel, Kenneth Thilakaratne, Chamath Keppitiyagama + 1 more
'Chamath Keppitiyagama' 'Kasun De Zoysa'] Hundreds of thousands of malicious domains are created by miscreants everyday. These malicious domains are hosted on a wide variety of network infrastructures. Traditionally, attackers utilize bullet proof hosting services (e.g. MaxiDed, Cyber Bunker) to take advantage of…
Fengyu Liu, Jiarun Dai, Yihe Fan, Wuyuao Mai + 10 more
Frontier AI systems are increasingly capable of cybersecurity tasks, including codebase inspection, vulnerability detection, and exploitation. However, evaluating their offensive capabilities remains constrained by limited access to open, reproducible, multi-host cyber ranges. Existing public benchmarks capture…
Chul Chung, Seunghyun Park, Junhyuk Son, Hyejeon Cho + 1 more
ubiquitous evidence from a larger sample of host galaxies in a broader redshift range Authors: ['Chul Chung' 'Seunghyun Park' 'Junhyuk Son' 'Hyejeon Cho' 'Young‐Wook Lee'] Type Ia supernovae (SNe Ia) serve as the most crucial standardizable candles in cosmology, providing direct measurements of the universe's expansion…
Martin Amezcua, Jeffry Setiadi, Yunhui Ge, David Mobley
The SAMPL series of challenges aim to focus the community on specific modeling challenges, while testing and hopefully driving progress of computational methods to help guide pharmaceutical drug discovery. In this study, we report on the results of the SAMPL8 host-guest blind challenge for predicting absolute binding…
Martyna W. Winiarska, S. I. Raimundo, Timothy A. Davis, Rogério Riffel + 2 more
luminosity of early- and late-type galaxies Authors: ['Martyna W. Winiarska' 'S. I. Raimundo' 'Timothy A. Davis' 'Rogério Riffel' 'Francesco Shankar' 'P. Wiseman'] The main fuelling processes for Active Galactic Nuclei (AGN) are currently unknown. Previous work showed that galaxies with a large kinematic misalignment…
Jeffry Setiadi, Simon Boothroyd, David Slochower, David Dotson + 4 more
Software to more rapidly and accurately predict protein--ligand binding affinities is of high interest for early-stage drug discovery, and physics-based methods are among the most widely used technologies for this purpose. The accuracy of these methods depends critically on the accuracy of the potential functions they…
Biao Chen, Wenhuan Huang, Guoqing Zhang
Chiral recognition with molecular luminescence is a beneficial but challenging method due to an often lack of dramatic difference in intermolecular interactions between the chiral analyte/substrate pair versus their enantiomeric counterpart. Here we show that the difference in room-temperature phosphorescence (RTP) can…