Search · four archives
Search · four archives
14 papers · ranked by Valyu relevance
Cameron G. Williams, Hyun Jae Lee, Takahiro Asatsuma, Roser Vento-Tormo + 1 more
'Roser Vento-Tormo' 'Ashraful Haque'] Single-cell transcriptomics (scRNA-seq) has become essential for biomedical research over the past decade, particularly in developmental biology, cancer, immunology, and neuroscience. Most commercially available scRNA-seq protocols require cells to be recovered intact and viable…
Wenhao Li, Yuan Zhou, Andrés Moya
Title: Simple Summary Spatial transcriptomics allows researchers to measure gene expression while preserving the positions of cells and molecules within tissues. Imaging-based spatial transcriptomics methods do this by directly visualizing RNA molecules or amplified signals in tissue samples, often at single-cell or…
Yoonji Lee, Mingyu Lee, Yoojin Shin, Kyuri Kim + 2 more
'Elisa De Paolis'] Spatial omics integrates molecular profiling with spatial tissue context, enabling high-resolution analysis of gene expression, protein interactions, and epigenetic modifications. This approach provides critical insights into disease mechanisms and therapeutic responses, with applications in cancer…
Tsai-Ying Chen, Li You, Jose Angelito U. Hardillo, Miao-Ping Chien + 2 more
'Johannes A. Schmid' 'Lu Xiao'] Spatial transcriptomic technologies enable measurement of expression levels of genes systematically throughout tissue space, deepening our understanding of cellular organizations and interactions within tissues as well as illuminating biological insights in neuroscience, developmental…
Bowen Zheng, Lin Fang
A major feature of cancer is the heterogeneity, both intratumoral and intertumoral. Traditional single-cell techniques have given us a comprehensive understanding of the biological characteristics of individual tumor cells, but the lack of spatial context of the transcriptome has limited the study of cell-to-cell…
Yuhong Hu, Hao Jia, Hao Cui, Jiangping Song
Cardiovascular diseases constitute a marked threat to global health, and the emergence of spatial omics technologies has revolutionized cardiovascular research. This review explores the application of spatial omics, including spatial transcriptomics, spatial proteomics, spatial metabolomics, spatial genomics, and…
Weizheng Liang, Zhenpeng Zhu, Dandan Xu, Peng Wang + 7 more
The development and progression of diseases in multicellular organisms unfold within the intricate three-dimensional body environment. Thus, to comprehensively understand the molecular mechanisms governing individual development and disease progression, precise acquisition of biological data, including genome…
Changxiang Huan, Jinze Li, Yingxue Li, Shasha Zhao + 8 more
'Zhiqi Zhang' 'Chuanyu Li' 'Shuli Li' 'Zhen Guo' 'Jia Yao' 'Wei Zhang' 'Lianqun Zhou'] Spatial monoomics has been recognized as a powerful tool for exploring life sciences. Recently, spatial multiomics has advanced considerably, which could contribute to clarifying many biological issues. Spatial monoomics techniques…
Minh H N Le, Thanh-Huy Nguyen, Tao Li, Bao Quang Gia Le + 6 more
Cardiovascular disease arises from interactions between inherited risk, molecular programmes, and tissue-scale remodelling that are observed clinically through imaging. Cardiac MRI (CMR), computed tomography (CT), and echocardiography are integral to routine cardiovascular care, while bulk RNA sequencing, single-cell…
Haoxiu Wang, Xinwang Yang, Siheng Wang, Zhe Yang + 23 more
Spatial omics technologys help overcome key limitations of conventional omics approaches that lack spatial information, by providing a panoramic perspective from the molecular level to the microenvironment scale for addressing spatially resolved biological questions in life sciences. With the rapid advancement of this…
Ruixuan Wang, Waylon J. Hastings, Julian G. Saliba, Duran Bao + 7 more
Nanotechnology for Spatial Omics: Biological Structures and Functions at Nanoscale Resolution Authors: ['Ruixuan Wang' 'Waylon J. Hastings' 'Julian G. Saliba' 'Duran Bao' 'Yuanyu Huang' 'Sudipa Maity' 'Omar Mustafa Kamal Ahmad' 'Logan Hu' 'Shengyu Wang' 'Jia Fan' 'Bo Ning'] Spatial omics methods are extensions of…
Han‐Eol Park, Song Hyun Jo, Rosalind H. Lee, Christian P. Macks + 5 more
'Taeyun Ku' 'Jihwan Park' 'Chung Whan Lee' 'Junho K. Hur' 'Chang Ho Sohn'] Title: Abstract Spatial transcriptomics is a newly emerging field that enables high-throughput investigation of the spatial localization of transcripts and related analyses in various applications for biological systems. By transitioning from…
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun + 2 more
Biological macromolecules assemble into sophisticated spatial architectures to orchestrate fundamental cellular processes. Understanding this architecture is therefore essential for deciphering the mechanisms of life. Driven by advances in high-throughput sequencing and single-molecule imaging, spatial omics…
Jiaxin Wan, Zhi Sun, Xueqiong Feng, Peipei Zhou + 12 more
'Zhouyang Jiao' 'Hui Cao' 'Chuang Zhang' 'Rijin Lin' 'Xiaowen Zhang' 'Mengyan Fan' 'Nan Zhang' 'Jiamei Zhang' 'Huixiang Liu' 'Jing Li' 'Sheng Guan'] Title: Abstract Atherosclerosis is a chronic inflammatory condition of the arteries, marked by the development of plaques within the arterial intima. The rupture of…