14 papers · ranked by Valyu relevance
Liam M. Rooney, Jay Christopher, Shannan Foylan, Charlie Butterworth + 7 more
Solid immersion lenses (SILs) enhance the spatial resolution of an optical microscope by increasing the effective numerical aperture (NA) without physical modification of the objective lens. However, SIL application remains limited by cost, fragility, and accessibility. We present a rapid, single-step fabrication…
Tianyang Lyu, Maxim D. Ballmer, Zhong-Hai Li, Man Hoi Lee + 3 more
The surface tectonic style of rocky planets controls interior evolution, geologic activity, dynamo action, atmospheric composition, and thus, habitability. In the solar system, Earth is unique in exhibiting plate tectonics, but it also displays a protracted history of diverse tectonic regimes. To understand the…
Cheng Gong, Pauline Affatato, Matt Fay, Sudha R. Guttikonda + 14 more
Modern biology increasingly depends on data-driven discovery, requiring scalable and affordable high-content 3D imaging across molecular to organ scales. Although tissue clearing, expansion microscopy, and light-sheet microscopy (LSM) enable subcellular-resolution imaging of intact specimens, their scalability remains…
Zehui Dong, Majid Haddad Momeni, Kim Olofsson, Eva Nordberg Karlsson
Lipases are vital in modifying lipid substrates across industries such as food, cosmetics, and pharmaceuticals. Among their features, fatty acid selectivity is particularly important for industrial applications. Rhizopus oryzae lipase (ROL) stands out for its high selectivity and broad applicability. In this study, we…
Emma E. Lietzke, Mary S. Rouse, Dean Oldham, Ziyue Dong + 3 more
Lipoprotein lipase (LPL) is the rate-limiting enzyme responsible for hydrolyzing triglycerides in circulating lipoproteins. Reduced LPL activity contributes to hypertriglyceridemia, a major cardiovascular risk factor. LPL activity is thought to depend on the conformation of the lid domain, the lipid pore, N- and…
Emma E. Lietzke, Mary S. Rouse, Dean Oldham, Ziyue Dong + 3 more
Lipoprotein lipase (LPL) is the rate-limiting enzyme responsible for hydrolyzing triglycerides in circulating lipoproteins. Reduced LPL activity contributes to hypertriglyceridemia, a major cardiovascular risk factor. LPL activity is thought to depend on the conformation of the lid domain, the lipid pore, N- and…
Jeffrey Chang, Nicholas F. Polizzi
Many biological proteins function by changing shape upon small-molecule binding. Here, we present a general strategy for designing de novo proteins that undergo small-molecule-induced conformational change. Our approach converts a preorganized small-molecule binding protein into a ligand-responsive shape-changer by…
Klaus N Quelhas, Richmond S Wang, Andrea Peruzzi, Weston L Tew
The triple points of carbon dioxide (TP CO2) and sulfur hexafluoride (TP SF6) have been studied over the last decade as alternative fixed points to the triple point of mercury (TP Hg, 234.3156 K) on the International Temperature Scale of 1990 (ITS-90). NIST has been developing TP CO2 and TP SF6 cells to be employed as…
Harish Katti, Aidan P. Murphy, Michael Helde, Harshawardhan Deshpande + 8 more
Vision is traditionally studied using simplified stimuli presented briefly near the center of a flat display while subjects maintain visual fixation. This paradigm contrasts sharply with real-world vision, which is immersive, dynamic and strongly entrained to self-initiated actions. Traditional approaches have allowed…
Eric Yeats, Aaron Jacobson, Darryl Hannan, Yiran Jia + 3 more
The local intrinsic dimension (LID) of data is a fundamental quantity in signal processing and learning theory, but quantifying the LID of high-dimensional, complex data has been a historically challenging task. Recent works have discovered that diffusion models capture the LID of data through the spectra of their…
Authors not listed
For decades, molecular visualization software has been fundamental to education and research in chemistry, structural biology, and materials science. These tools have enabled the inspection of structures, dynamics, and interactions, yet their reliance on two-dimensional (2D) interfaces imposes persistent limitations.…
Bowen Cha, Jun Luo, Zilong Guo, Haim Abramovich
Aiming at the technical pain points of traditional manhole covers with low intelligence high cost and excessive power consumption, this study designs a TENG-based alarm device to enhance the safety and maintenance efficiency of urban infrastructure. The device integrates a water immersion sensor and a displacement…
Yuansan Liu, Antoinette Tordesillas, James Bailey
Local Intrinsic Dimensionality (LID) has shown strong potential for identifying anomalies and outliers in high-dimensional data across a wide range of real-world applications, including landslide failure detection in granular media. Early and accurate identification of failure zones in landslide-prone areas is crucial…
Katsuhiro Mikami, Ryoichi Akiyoshi, Yasuhiro Miyasaka, Luca Poletto + 1 more
We present a photoacoustic spectroscopy (PAS)-based method using a laser Doppler vibrometer (LDV) for real-time detection of laser-induced damage (LID) in optical components. By measuring audible frequency surface vibrations, the method enables remote, non-contact, and sensitive detection. Experiments with various…