19 papers · ranked by Valyu relevance
Alexandra S. Cao, Stephen D. Van Hooser
The transmission of high frequency temporal information across brain regions is critical to perception, but the mechanisms underlying such transmission remain unclear. Long-range projection patterns across brain areas are often comprised of paired feed-forward excitation followed closely by delayed inhibition…
Eilam Goldenberg Leleo, Idan Segev, Michele Migliore
The output of neocortical layer 5 pyramidal cells (L5PCs) is expressed by a train of single spikes with intermittent bursts of multiple spikes at high frequencies. The bursts are the result of nonlinear dendritic properties, including Na+, Ca2+, and NMDA spikes, that interact with the ~10,000 synapses impinging on the…
Sally Horton, Vincenzo Mastrolia, Rachel Jackson, Sarah Kemlo + 7 more
A balance between excitation and inhibition is crucial for neurotypical brain function. Indeed, disruptions in this relationship are frequently associated with the pathophysiology of neurodevelopmental disorders. Nevertheless, how this balance is established during the dynamic period of neurodevelopment remains…
A. Fiasconaro, Michele Migliore
We study the synchronisation of neurons in a realistic model under the Hodgkin-Huxley dynamics. To focus on the role of the different locations of the excitatory synapses, we use two identical neurons where the set of input signals is grouped at two different distances from the soma. The system is intended to represent…
Matthew Fischl, Alia Pederson, Rebecca Voglewede, Hui Cheng + 3 more
'Jordan Drew' 'Lester Torres Cadenas' 'Catherine J. C. Weisz'] The encoding of acoustic stimuli requires precise neuron timing. Auditory neurons in the cochlear nucleus (CN) and brainstem are well suited for accurate analysis of fast acoustic signals, given their physiological specializations of fast membrane time…
Felix Benjamin Kern, Takahisa Date, Zenas C. Chao
Neural systems are hypothesized to operate near criticality, enhancing their capacity for optimal information processing, transmission and storage capabilities. Criticality has typically been studied in spiking neural networks and related systems organized in random or full connectivity, with the balance of excitation…
Alain de Cheveigné
This paper suggests an explanation for listeners’ greater tolerance to positive than negative mistuning of the higher tone within an octave pair. It hypothesizes a neural circuit tuned to cancel the lower tone, that also cancels the higher tone if that tone is in tune. Imperfect cancellation is the cue to mistuning of…
Abdelmalik Moujahid, Fernando Vadillo
Mathematical modeling is an important tool to study the role of delay in neural systems and to evaluate its effects on the signaling activity of coupled neurons. Models for delayed neurons are often used to represent the dynamics of real neurons, but rarely to assess the energy required to maintain these dynamics. In…
Jung-Hwa Tao-Cheng, Sandra Lara Moreira, Christine A. Winters
The present study uses electron microscopy to document ultrastructural characteristics of hippocampal GABAergic inhibitory synapses under resting and stimulated conditions in three experimental systems. Synaptic profiles were sampled from stratum pyramidale and radiatum of the CA1 region from (1) perfusion fixed mouse…
Matheus Hansen, Paulo R. Protachevicz, Kelly C. Iarosz, Iberê L. Caldas + 2 more
'Iberê L. Caldas' 'Antônio M. Batista' 'Elbert E. N. Macau'] We study the time delay in the synaptic conductance for suppression of spike synchronisation in a random network of Hodgkin Huxley neurons coupled by means of chemical synapses. In the first part, we examine in detail how the time delay acts over the network…
Hananel Hazan, Simon Caby, Christopher Earl, Hava T. Siegelmann + 1 more
'Michael Levin'] A common view in the neuroscience community is that memory is encoded in the connection strength between neurons. This perception led artificial neural network models to focus on connection weights as the key variables to modulate learning. In this paper, we present a prototype for weightless spiking…
Prudhvi Raj Rayi, Shaya Lev, Alexander M Binshtok
The excitatory and inhibitory interneurons of superficial laminae I-II of the spinal dorsal horn (SDH) receive and process pain-related information from the primary afferents and transmit it to the brain via the projection neurons. Thus, the interaction between excitatory and inhibitory SDH interneurons is crucial in…
Roy Meijer, Paul Detterer, Amirreza Yousefzadeh, Alberto Saucedo + 7 more
Accelerators Authors: ['Roy Meijer' 'Paul Detterer' 'Amirreza Yousefzadeh' 'Alberto Saucedo' 'Guoqiang Tang' 'Kanishkan Vadivel' 'Yan Xu' 'Manil Dev Gomony' 'Federico Corradi' 'B. Linares-Barranco' 'Manolis Sifalakis'] Abstract—Synaptic delay parameterization of neural network models have remained largely unexplored…
Daniel Trpevski, Jeanette Hellgren Kotaleski, Matthias Hennig
Inhibitory synapses can control a neuron’s firing rate and also control supralinear dendritic integration. It is not known how inhibitory synapses can learn to perform these functions using only signals available locally at the synaptic site. We study an inhibitory plasticity rule based on the Bienenstock-Cooper-Munro…
Jiannis Taxidis, Blake Madruga, Maxwell D Melin, Michael Z Lin + 1 more
Hippocampal spiking sequences encode and link behavioral information across time. How inhibition sculpts these sequences remains unknown. We performed longitudinal voltage imaging of CA1 parvalbumin- and somatostatin-expressing interneurons in mice during an odor-cued working memory task, before and after training.…
Sami Boudkkazi, Dominique Debanne, Katsuhiko Tabuchi
Neuronal timing with millisecond precision is critical for many brain functions such as sensory perception, learning and memory formation. At the level of the chemical synapse, the synaptic delay is determined by the presynaptic release probability (Pr) and the waveform of the presynaptic action potential (AP). For…
A. Fiasconaro, Michele Migliore
This work delves into studying the synchronization in two realistic neuron models using Hodgkin-Huxley dynamics. Unlike simplistic point-like models, excitatory synapses are here randomly distributed along the dendrites, introducing strong stochastic contributions into their signal propagation. To focus on the role of…
Santa Fukuda, Yuki Hayashida
Cathodic-first biphasic current pulses are commonly employed in intracortical microstimulation. Due to the intricate arrangement of axons, somata, and dendrites in the cerebral cortex, membrane polarizations induced by the cathodic and subsequent anodic phases of biphasic pulses may interact in a location-, magnitude-…
Gáspár Oláh, Rajmund Lákovics, Sapir Shapira, Yoni Leibner + 6 more
Human-specific cognitive abilities depend on information processing in the cerebral cortex, where neurons are significantly larger and sparser compared to rodents. We found that, in synaptically-connected layer 2/3 pyramidal cells (L2/3 PCs), soma-to-soma signal propagation delay is similar in humans and rodents. Thus…