10 papers · ranked by Valyu relevance
ChenTianyi Yang, Andrew Thwaites, Cai Wingfield, Chao Zhang + 1 more
The brain builds meaning from speech in stages, transforming acoustic input into linguistic comprehension. Yet where comprehension separates from general acoustic processing has been difficult to localize, because the two are tightly entangled in continuous speech. Here we align the activity of 145,000 individual…
Emily Cordeiro, Daniela Herrera Chaves, Nima Talei, Iván Castro + 6 more
Statistical learning (SL) has been proposed to depend on the hippocampus, but traditional neuropsychological theories of long-term memory posit that the hippocampus is only necessary for explicit memory processes, not implicit memory processes. To reconcile these two accounts, we exposed 27 temporal lobe epilepsy (TLE)…
Amélie Barozet, Vincent Cabeli, Jean Ogier du Terrail, Alexey Rukhovich + 6 more
The development of climate-resilient crops would be greatly accelerated by models able to reason directly over plant genomic sequences and to pinpoint trait-associated regions or loci. Anticipating the impact of DNA base changes (variants) remains challenging, and understanding regulatory mechanisms is still an active…
Seonghwan Seo, Hyeongwoo Kim, Seokhyun Moon, Woo Youn Kim
Protein language models (PLMs) trained on evolutionary sequences learn representations that encode protein structure, enabling direct structure prediction without multiple-sequence alignments (MSAs). Here we present the Atlas model family, an open and trainable system spanning protein language modeling, monomer…
Maria Juliana Rodriguez-Cubillos, Tomasz Zieliński, Jason R. Swedlow, T. Ian Simpson + 1 more
Ensuring the availability and accessibility of research data is fundamental to advancing knowledge, as codified in the FAIR principles (Findable, Accessible, Interoperable, and Reusable). Accurate metadata documentation is indispensable for meeting these principles; however, entries in deposition databases often…
Giansalvo Cirrincione, Elisa Ficarra, Marta Lovino
Protein language models (pLMs) such as ESM-2 and ProtBERT rely on pretraining corpora of tens to hundreds of millions of sequences and on encoder architectures whose depth, width and number of attention heads are chosen by the practitioner and never revisited during training. The entry cost of state-of-the-art pLMs is…
Jennifer Doralt, Bernie Keohane, Adrienne McGilvray, Daniela Pobinger + 1 more
Background: Plain language summaries (PLSs) play a crucial role in communicating complex clinical trial information to patients and the public. Due to the European Union Clinical Trials Regulation (EU CTR) 536/2014 requirement to disclose PLSs in parallel with the technical results, clinical trial sponsors will need to…
Suji Jung, Jieun Kiaer, Naya Choi
Korean negation has two forms, Short-Form Negation (SFN) and Long-Form Negation (LFN), claimed to have different pragmatic meanings in terms of formality. This paper investigated whether Korean 5-year-old children and adults responded to the level of formality in a conversation, using an experimental design in which a…
Yiming Xue, Xiaojian Liu, Weimin Zhu, Shengfan Wang + 2 more
While protein-RNA interactions are fundamental to post-transcriptional processes, achieving a holistic understanding of their regulatory logic remains challenging. Current computational models often treat binding affinity, interface mapping, and RNA design as isolated tasks, thereby failing to provide a unified…
Qing Du, Wenwen Liang, Yifan Fang, Tianyi Li + 3 more
5## Conclusion In this multicenter cohort of acute ischemic stroke, symptom-network and flow analyses suggested that post-stroke dysfunction is embedded in a broader pattern of depressive and cognitive symptoms rather than reflecting global severity alone. In the flow network, Loss of interest and Suicidality showed…