13 papers · ranked by Valyu relevance
Matthew R. Whiteway, Daniel A. Butts
The activity of sensory cortical neurons is not only driven by external stimuli, but is also shaped by other sources of input to the cortex. Unlike external stimuli these other sources of input are challenging to experimentally control or even observe, and as a result contribute to variability of neuronal responses to…
Alexander von Eye, Wolfgang Wiedermann, Stefan von Weber
In this article, we demonstrate that latent variable analysis can be of great use in person-oriented research. Starting with exploratory factor analysis of metric variables, we present an example of the problems that come with generalization of aggregate-level results to subpopulations. Oftentimes, results that are…
Matthew Farrell, Stefano Recanatesi, R. Clay Reid, Stefan Mihalas + 1 more
Spectacular advances in imaging and data processing techniques are revealing a wealth of information about brain connectomes. This raises an exciting scientific opportunity: to infer the underlying circuit function from the structure of its connectivity. A potential roadblock, however, is that – even with well…
Nicola Melillo, Adam S. Darwich
In drug development decision-making is often supported through model-based methods, such as physiologically-based pharmacokinetics (PBPK). Global sensitivity analysis (GSA) is gaining use for quality assessment of model-informed inference. However, the inclusion and interpretation of correlated factors in GSA has…
Angela Sorgente, Rossella Caliciuri, Matteo Robba, Margherita Lanz + 1 more
Latent class analysis (LCA) can help identify unobserved classes of individuals in a population based on collected categorical data. It is commonly used in psychology to test hypotheses about sources of heterogeneity and class characteristics. However, careful decision-making is required in the modeling process. Its…
Ji Hoon Ryoo, Cixin Wang, Susan M. Swearer, Michael Hull + 1 more
In the areas of social and behavioral sciences, factor analysis has been a long-standing analytic strategy to understand unobserved (or latent) constructs as well as their internal structure from observed data (Cudeck and MacCallum, ). When the unobserved constructs are introduced using factor analysis, researchers are…
Muhammad Ammar Malik, Tom Michoel
Random effect models are popular statistical models for detecting and correcting spurious sample correlations due to hidden confounders in genome-wide gene expression data. In applications where some confounding factors are known, estimating simultaneously the contribution of known and latent variance components in…
Bert van der Veen, Francis K.C. Hui, Knut A. Hovstad, Robert B. O’Hara
In community ecology, unconstrained ordination can be used to predict latent variables from a multivariate dataset, which generated the observed species composition. Latent variables can be understood as ecological gradients, which are represented as a function of measured predictors in constrained ordination, so that…
Augustin Kelava, Holger Brandt
In the past 2 decades latent variable modeling has become a standard tool in the social sciences. In the same time period, traditional linear structural equation models have been extended to include non-linear interaction and quadratic effects (e.g., Klein and Moosbrugger, [41]), and multilevel modeling (Rabe-Hesketh…
Pär Jonsson, Benny Björkblom, Elin Chorell, Tommy Olsson + 1 more
Multivariate projection methods are unique in being both multivariable by combining many variables into stronger predictive features (latent variables), and multivariate for being able to model systematic variation both related and orthogonal to an observed response. Orthogonal partial least squares (OPLS) is a…
John M. Felt, Sarah Depaoli, Jitske Tiemensma
Objective: The stress response is a dynamic process that can be characterized by predictable biochemical and psychological changes. Biomarkers of the stress response are typically measured over time and require statistical methods that can model change over time. One flexible method of evaluating change over time is…
Ruofan Wang, Lei Fang, Yue Wang, Jin Jin
Leveraging observational data to understand the associations between risk factors and disease outcomes and conduct disease risk prediction is a common task in epidemiology. While traditional linear regression and other machine learning models have been extensively implemented for this task, the associations between…
Roberto Di Mari, Zsuzsa Bakk, Jennifer Oser, Jouni Kuha
We propose a two-step estimator for multilevel latent class analysis (LCA) with covariates. The measurement model for observed items is estimated in its first step, and in the second step covariates are added in the model, keeping the measurement model parameters fixed. We discuss model identification, and derive an…