22 papers · ranked by Valyu relevance
Greta R. Bauer, Mayuri Mahendran, Chantel Walwyn, Mostafa Shokoohi
Purpose An intersectionality framework has been increasingly incorporated into quantitative study of health inequity, to incorporate social power in meaningful ways. Researchers have identified “person-centered” methods that cluster within-individual characteristics as appropriate to intersectionality. We aimed to…
Alexander von Eye, Wolfgang Wiedermann, Stefan von Weber
In this article, we demonstrate that latent variable analysis can be of great use in person-oriented research. Starting with exploratory factor analysis of metric variables, we present an example of the problems that come with generalization of aggregate-level results to subpopulations. Oftentimes, results that are…
Bert van der Veen, Francis K.C. Hui, Knut A. Hovstad, Robert B. O’Hara
In community ecology, unconstrained ordination can be used to predict latent variables from a multivariate dataset, which generated the observed species composition. Latent variables can be understood as ecological gradients, which are represented as a function of measured predictors in constrained ordination, so that…
Zexi Song, Zhiqiang Tan
Generalized linear mixed models are useful in studying hierarchical data with possibly non-Gaussian responses. However, the intractability of likelihood functions poses challenges for estimation. We develop a new method suitable for this problem, called imputation maximization stochastic approximation (IMSA). For each…
Tamara Schamberger, Florian Schuberth, Jörg Henseler, Yves Rosseel
Structural equation modeling (SEM) is a prevalent approach for studying constructs. Traditionally, these constructs are modeled as reflectively measured latent variables – common factors that account for the variance-covariance structure of their associated indicators. Over the past two decades, there has been growing…
Angela Sorgente, Rossella Caliciuri, Matteo Robba, Margherita Lanz + 1 more
Latent class analysis (LCA) can help identify unobserved classes of individuals in a population based on collected categorical data. It is commonly used in psychology to test hypotheses about sources of heterogeneity and class characteristics. However, careful decision-making is required in the modeling process. Its…
Tetsuro Morimura, Tatsushi Oka, Suzuki, Yugo + 1 more
Latent variable models provide a powerful framework for incorporating and inferring unobserved factors in observational data. In causal inference, they help account for hidden factors influencing treatment or outcome, thereby addressing challenges posed by missing or unmeasured covariates. This paper proposes a new…
Jerzak, Connor T., Jessee, Stephen A.
Many core concepts in political science are latent and therefore can only be measured with error. Measurement error in a predictor attenuates slope coefficient estimates in regression, biasing them toward zero. We show that widely used strategies for correcting attenuation bias—including instrumental variables and the…
Luna Fazio, Paul‐Christian Bürkner
modeling latent heteroscedasticity Authors: ['Luna Fazio' 'Paul‐Christian Bürkner'] Accounting for the complexity of psychological theories requires methods that can predict not only changes in the means of latent variables – such as personality factors, creativity, or intelligence – but also changes in their…
Changmin Yu, Maneesh Sahani, Máté Lengyel
Gaussian Process Factor Analysis (GPFA) is a powerful latent variable model for extracting low-dimensional manifolds underlying population neural activities. However, one limitation of standard GPFA models is that the number of latent factors needs to be pre-specified or selected through heuristic-based processes, and…
Ruofan Wang, Lei Fang, Yue Wang, Jin Jin
Leveraging observational data to understand the associations between risk factors and disease outcomes and conduct disease risk prediction is a common task in epidemiology. While traditional linear regression and other machine learning models have been extensively implemented for this task, the associations between…
Matthew Heaney, Olive Healy, Jason Wyse, Arthur White
Sleep difficulties in children are heterogeneous in presentation, yet conventional assessment tools like the Children's Sleep Habits Questionnaire (CSHQ) reduce this complexity to a single cumulative score, obscuring distinct patterns of sleep disturbance that require different interventions. Latent Class Regression…
Samuel Renaud, Rachael Mansbach
Current antibacterial treatments cannot overcome the rapidly growing resistance of bacteria to antibiotic drugs, and novel treatment methods are required. One option is the development of new antimicrobial peptides (AMPs), to which bacterial resistance build-up is comparatively slow. Deep generative models have…
Ziang Zhang, Jerald F. Lawless, Andrew D. Paterson, Lei Sun
In genome-wide association studies (GWAS), it is desirable to test for interactions (GxE) between single-nucleotide polymorphisms (SNPs,G’s) and environmental variables (E’s). However, directly accounting for interaction is often infeasible, because E is latent. For quantitative traits (Y) that are approximately…
David Buterez, Jon Paul Janet, Steven Kiddle, Pietro Liò
We investigate the potential of graph neural networks for transfer learning and improving molecular property prediction on sparse and expensive to acquire high-fidelity data by leveraging low-fidelity measurements as an inexpensive proxy for a targeted property ofinterest. This problem arises in discovery processes…
Tyler J. VanderWeele, Stijn Vansteelandt
Factor analysis is often used to assess whether a single univariate latent variable is sufficient to explain most of the covariance among a set of indicators for some underlying construct. When evidence suggests that a single factor is adequate, research often proceeds by using a univariate summary of the indicators in…
Authors not listed
Computational methods for generating molecules with specific physiochemical properties or biolog- ical activity can greatly assist drug discovery efforts. Deep learning generative models constitute a significant step towards that direction. In this work, we introduce a novel approach that utilizes a Reinforcement…
Roberto Di Mari, Zsuzsa Bakk, Jennifer Oser, Jouni Kuha
We propose a two-step estimator for multilevel latent class analysis (LCA) with covariates. The measurement model for observed items is estimated in its first step, and in the second step covariates are added in the model, keeping the measurement model parameters fixed. We discuss model identification, and derive an…
Tagir Akhmetshin, Arkadii Lin, Timur Madzhidov, Alexandre Varnek
Autoencoders represent a promising technique for the inverse quantitative structure-activity relationship (QSAR) task. However, undesirable bias, such as atom ordering, affects the neighbourhood behaviour of autoencoders’ latent space and, consequently, usage of the latent vectors as variables in machine-learning…
Pavel Kohout, Michal Vasina, Marika Majerova, Veronika Novakova + 5 more
Enzymes play a crucial role in sustainable industrial applications, with their optimization posing a formidable challenge due to the intricate interplay among residues. Computational methodologies predominantly rely on evolutionary insights, leveraging homologous sequences to pinpoint conserved and functionally…
Roberto Di Mari, Zsuzsa Bakk, Jennifer Oser, Jouni Kuha
We propose a two-step estimator for multilevel latent class analysis (LCA) with covariates. The measurement model for observed items is estimated in its first step, and in the second step covariates are added in the model, keeping the measurement model parameters fixed. We discuss model identification, and derive an…
Mark de Rooij, Ligaya Breemer, Dion Woestenburg, Frank Busing
We present a multidimensional data analysis framework for the analysis of ordinal response variables. Underlying the ordinal variables, we assume a continuous latent variable, leading to cumulative logit models. The framework includes unsupervised methods, when no predictor variables are available, and supervised…