10 papers · ranked by Valyu relevance
Amélie Barozet, Vincent Cabeli, Jean Ogier du Terrail, Alexey Rukhovich + 6 more
The development of climate-resilient crops would be greatly accelerated by models able to reason directly over plant genomic sequences and to pinpoint trait-associated regions or loci. Anticipating the impact of DNA base changes (variants) remains challenging, and understanding regulatory mechanisms is still an active…
Shanti Prasad Khanal, Chitra Bahadur Budhathoki, Bhimsen Devkota, Shyam Krishna Maharjan + 1 more
Background: Evidence indicates a lack of school-based interventions targeting adolescents' health literacy. To date, no structured, theory-driven, Delphi-guided health literacy intervention has been designed for Nepalese adolescents. Objective: This study aims to report the systematic development of a context-specific…
Sahar Alkhaibari, Feng Dong
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by persistent difficulties in social communication, social interaction, and repetitive behaviors. Early and accurate diagnosis is essential but is often hindered by subjective clinical assessments, limited data availability, and…
Yuesong Wu, Haohao Su, Yuehua Cui
Cell-cell communication (CCC) is essential for maintaining tissue organization and driving biological progression, yet its inference from transcriptomic data has long been limited by the absence of spatial context. Advances in spatial transcriptomics (ST) now enable mechanistically grounded analyses of CCC by…
Emily Cordeiro, Daniela Herrera Chaves, Nima Talei, Iván Castro + 6 more
Statistical learning (SL) has been proposed to depend on the hippocampus, but traditional neuropsychological theories of long-term memory posit that the hippocampus is only necessary for explicit memory processes, not implicit memory processes. To reconcile these two accounts, we exposed 27 temporal lobe epilepsy (TLE)…
Vajiheh Marsoosi, Laleh Eslamian, Sotoudeh Mohammadi, Lida Mohamadpour + 5 more
1## INTRODUCTION Twin-twin transfusion syndrome (TTTS) affects approximately 10%-15% of monochorionic twin pregnancies, significantly increasing prenatal mortality and neurological morbidity in affected fetuses . This condition arises from imbalanced blood flow between the fetuses through placental anastomoses, leading…
Kapali Suri, Anshul Yadav, Abhishek Tripathi, N. Arul Murugan
Protein-ligand pose prediction is central to structure-based drug discovery, yet the relative performance of physics-based and AI-driven methods under realistic cross-docking conditions remains insufficiently characterized. Here, we compare physics-based docking methods (AutoDock4, AutoDock Vina, and DOCK 6) with…
Megan Sholomiski, Victor Yon, Franziska Mudlaff, Aparna Suvrathan
The cerebellum supports a wide range of motor and non-motor behaviors, yet the specific cerebellar regions and neuronal populations underlying this functional diversity remain poorly understood. Here, we mapped patterns of immediate early gene activation in the cerebellar cortex during the accelerating rotarod task, an…
Coen S. Zandvoort, Charlotte C. Wissing, Jonathan Winter, Anna Kowalczyk + 4 more
Flexible motor control requires that movements adapt to changing temporal contexts. Here, we test whether flexible timing is driven by context-dependent encoding across cortico-cerebellar circuits and how neural dynamics within these circuits enable accurate performance. To overcome the signal-to-noise limitations of…
Yi Ren, Zimei Chen, Hayden Deans, Ying Nian Wu + 1 more
Extensive studies suggest the brain performs Bayesian inference to infer the latent world states. It is a fundamental neuroscience question that how canonical recurrent neural circuits in the brain implement Bayesian inference. Many existing theoretical studies focused on how the recurrent circuits compute the…