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Search · four archives
18 papers · ranked by Valyu relevance
Guoli Cheng, Yizong Wang, Dianguo Dong, Wenjie Zhang + 2 more
'Zhaojun Wan'] This study aimed to evaluate the efficacy and safety of iodine 125 (125I) radioactive seed implantation for small cell lung cancer at the limited stage of relapse as second line therapy. We collected 6 patients with recurred limited stage small cell lung cancer, who got pathological diagnosis after a…
Michael Stokes, Noami Berfeld, Alicia Gayle, Andrew Descoteaux + 2 more
'Oscar Rohrmoser' 'April Franks'] Title: Background: Robust evidence from real-world studies is needed to aid decision-makers and other stakeholders in choosing the best treatment options for patients. The objective of this work was to assess real-world outcomes of treatment strategies for limited- and extensive-stage…
Yukinori Okada, Tatsuhiko Zama, Tomohiro Itonaga, Ryuji Mikami + 6 more
'Mitsuru Okubo' 'Shinji Sugahara' 'Motoki Nakai' 'Koichiro Abe' 'Mana Yoshimura' 'Kazuhiro Saito'] Background Research on the relationship between neuron-specific enolase (NSE) levels and normal organs, particularly the central nervous system, in small cell lung cancer is limited. Therefore, this study aimed to…
Evgenii Skurikhin, Olga Pershina, Mariia Zhukova, Darius Widera + 6 more
'Natalia Ermakova' 'Edgar Pan' 'Angelina Pakhomova' 'Sergey Morozov' 'Aslan Kubatiev' 'Alexander Dygai'] Despite the increasing urgency of the problem of treating small cell lung cancer (SCLC), information on the causes of its development is fragmentary. There is no complete understanding of the features of antitumor…
Charles Ricordel, Laura Chaillot, Efstathios-Iason Vlachavas, Marianthi Logotheti + 14 more
Circulating Tumor Cells (CTC) have been studied in various solid tumors. However, clinical utility of CTC in Small Cell Lung Cancer (SCLC) remains to be demonstrated. Most published studies are based on Cellsearch® isolation methods that did not capture CTC undergoing epithelial-mesenchymal transition. The aim of the…
Alessandro Dal Maso, Federica Ferrarini, Giovanni Esposito, Sonia Anna Minuzzo + 14 more
'Sonia Anna Minuzzo' 'Anna Maria Puggia' 'Federica Pezzuto' 'Elisabetta Zulato' 'Loc Carlo Bao' 'Mattia De Nuzzo' 'Alessandra Ferro' 'Stefano Frega' 'Giulia Pasello' 'Fiorella Calabrese' 'Matteo Fassan' 'Federico Rea' 'Valentina Guarneri' 'Stefano Indraccolo' 'Laura Bonanno'] Background Small cell lung cancer (SCLC) is…
Jacob Sands, Janakiraman Subramanian
Extensive-stage small-cell lung cancer (ES-SCLC) is an aggressive disease with poor 5-year survival. The first-line standard-of-care for ES-SCLC is platinum plus etoposide, along with 1 of the immune checkpoint inhibitors atezolizumab or durvalumab. Although SCLC first-line therapy often leads to rapid responses…
Massimiliano Cani, Valerio Maria Napoli, Edoardo Garbo, Giorgia Ferrari + 4 more
'Giorgia Ferrari' 'Benedetta Del Rio' 'Silvia Novello' 'Francesco Passiglia' 'Robert Arthur Kratzke'] The clinical management of small cell lung cancer (SCLC) treatment remains a major challenge for thoracic oncologists, with very few therapeutic advances significantly impacting patients’ survival. The recent…
Sk. Kayum Alam, Anuradha Pandit, Li Wang, Britteny A. Thiele + 5 more
Small cell lung cancer (SCLC) is difficult to treat due to its aggressiveness, early metastasis, and rapid development of resistance to chemotherapeutic agents. Here, we show that treatment with a dopamine D_2_ receptor (D_2_R) agonist reduces tumour angiogenesis in multiple in vivo xenograft models of human SCLC…
Shreoshi Pal Choudhuri, Luc Girard, Jun Yi Stanley Lim, Jillian F. Wise + 18 more
Small cell lung cancer (SCLC) presents as a highly chemosensitive malignancy but acquires cross-resistance after relapse. This transformation is nearly inevitable in patients but has been difficult to capture in laboratory models. Here we present a pre-clinical system that recapitulates acquired cross-resistance in…
Wei Liu, Hongying Feng, Paige A. Taylor, Minglei Kang + 12 more
Hypofractionated Radiation Therapy for Thoracic Malignancies: Patterns of Practice Survey and Recommendations for Future Development from NRG Oncology and PTCOG Authors: ['Wei Liu' 'Hongying Feng' 'Paige A. Taylor' 'Minglei Kang' 'Jiajian Shen' 'Jatinder Saini' 'Jun Zhou' 'Huan Giap' 'Nathan Y. Yu' 'Terence S. Sio'…
Zhuo Wang, Qing Luo, Jie Wu, Li Lu + 11 more
Combined small-cell lung cancer (cSCLC) is a rare and aggressive subtype of small-cell lung cancer (SCLC) characterized by mixed histology comprising SCLC and non-small cell lung cancer (NSCLC) or large cell neuroendocrine carcinoma (LCNEC) components. Despite its histological heterogeneity and even poorer prognosis…
Akash Saha, Paul Grevitt, Jair Marques Junior, Alex Von Kriegsheim + 6 more
LIMD1 (LIM domains containing 1) is a bona-fide tumour suppressor gene frequently lost during the early stages of non-small cell lung cancer (NSCLC) development, resulting in a worse outcome for LIMD1-deficient patients. LIMD1 deficiency is present in approximately 50% of NSCLC cases, representing at least 21,000…
Hesamoddin Hosseini, Reza Monsefi, Shabnam Shadroo
Lung cancer has been one of the most prevalent disease in recent years. According to the research of this field, more than 200,000 cases are identified each year in the US. Uncontrolled multiplication and growth of the lung cells result in malignant tumour formation. Recently, deep learning algorithms, especially…
Lian Yang, Ming Xiao, Xian Li, Yalan Wang
TTF1 and ΔNp63/p40 have been used to differentiate ADC and SQC in hypofractionated NSCLC because of their sensitivity and specificity. There are few cases where TTF1 and ΔNp63/p40 are expressed together in the same tumour cells, and little is known about the clinicopathological features, treatment and prognosis of such…
Ayooluwa Ilesanmi, Gbenga Dairo, Toheeb Balogun, Bibiire Awoyale
Lung cancer is the cancer of the lung's epithelial cells typically characterized by difficult breathing, chest pain, blood-stained coughs, headache, and weight loss. If left unmanaged, lung cancer can spread to other body parts. While several treatment methods exist for managing lung cancer, exploring natural plant…
Authors not listed
Immuno-oncology, a rapidly evolving field at the forefront of cancer research, leverages the body’s immune system to fight cancer. In this follow up report, we extend our natural language processing (NLP)-based analysis to pinpoint the context of emergence of the previously identified emerging concepts. To achieve this…
Kavita Iyer, Julian Ivanov, Rumiana Tenchov, Krittika Ralhan + 4 more
Rapid and sustained growth in the field of immuno-oncology has resulted in expansion of available scientific literature. Gaining valuable insights and establishing deep and often hidden meaningful connections in such a large body of work is the need of the hour. In this report we summarize our findings from a novel…