17 papers · ranked by Valyu relevance
Iain M. Dykes, Costanza Emanueli
Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding RNA (lncRNA), a heterogeneous group of largely uncharacterised…
Jasdeep Kaur Dhanoa, Ram Saran Sethi, Ramneek Verma, Jaspreet Singh Arora + 1 more
The central dogma of gene expression propounds that DNA is transcribed to mRNA and finally gets translated into protein. Only 2-3% of the genomic DNA is transcribed to protein-coding mRNA. Interestingly, only a further minuscule part of genomic DNA encodes for long non-coding RNAs (lncRNAs) which are characteristically…
Victoria E. Villegas, Peter G. Zaphiropoulos, Martin Pichler
Antisense transcription, considered until recently as transcriptional noise, is a very common phenomenon in human and eukaryotic transcriptomes, operating in two ways based on whether the antisense RNA acts in cis or in trans. This process can generate long non-coding RNAs (lncRNAs), one of the most diverse classes of…
Jing Li, Zhenyu Xuan, Changning Liu
Long non-coding RNAs (lncRNAs) are a heterogeneous class of RNAs that are generally defined as non-protein-coding transcripts longer than 200 nucleotides. Recently, an increasing number of studies have shown that lncRNAs can be involved in various critical biological processes, such as chromatin remodeling, gene…
Marina R. Hadjicharalambous, Mark A. Lindsay
Innate immunity provides the initial defence against infection and it is now clear that long non-coding RNAs (lncRNAs) are important regulators of this response. Following activation of the innate response, we commonly see rapid induction of these lncRNAs and this is often mediated via the pro-inflammatory…
Beata Smolarz, Anna Zadrożna-Nowak, Hanna Romanowicz, Peter Hamar
Long noncoding RNAs (lncRNAs) are the largest groups of ribonucleic acids, but, despite the increasing amount of literature data, the least understood. Given the involvement of lncRNA in basic cellular processes, especially in the regulation of transcription, the role of these noncoding molecules seems to be of great…
John S. Mattick
Transcriptomic studies have demonstrated that the vast majority of the genomes of mammals and other complex organisms is expressed in highly dynamic and cell-specific patterns to produce large numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Despite well characterized examples…
Gabriela Marisol Cruz-Miranda, Alfredo Hidalgo-Miranda, Diego Alberto Bárcenas-López, Juan Carlos Núñez-Enríquez + 3 more
Acute leukemia (AL) is the main type of cancer in children worldwide. Mortality by this disease is high in developing countries and its etiology remains unanswered. Evidences showing the role of the long non-coding RNAs (lncRNAs) in the pathophysiology of hematological malignancies have increased drastically in the…
Li Chen, Qian-Hao Zhu, Kerstin Kaufmann
Main conclusion Long non-coding RNAs modulate gene activity in plant development and stress responses by various molecular mechanisms. Abstract Long non-coding RNAs (lncRNAs) are transcripts larger than 200 nucleotides without protein coding potential. Computational approaches have identified numerous lncRNAs in…
Lambros T. Koufariotis, Yi-Ping Phoebe Chen, Amanda Chamberlain, Christy Vander Jagt + 2 more
'Christy Vander Jagt' 'Ben J. Hayes' 'Marinus F.W. te Pas'] Long non-coding RNA (lncRNA) have been implicated in diverse biological roles including gene regulation and genomic imprinting. Identifying lncRNA in bovine across many differing tissue would contribute to the current repertoire of bovine lncRNA, and help…
Romana Butova, Petra Vychytilova-Faltejskova, Adela Souckova, Sabina Sevcikova + 1 more
'Sabina Sevcikova' 'Roman Hajek'] Multiple myeloma (MM) is the second most common hematooncological disease of malignant plasma cells in the bone marrow. While new treatment brought unprecedented increase of survival of patients, MM pathogenesis is yet to be clarified. Increasing evidence of expression of long…
Joice de Faria Poloni, Fábio Henrique Schuster de Oliveira, Bruno César Feltes
'Bruno César Feltes'] To understand the transcriptomic profile of an individual cell in a multicellular organism, we must comprehend its surrounding environment and the cellular space where distinct molecular stimuli responses are located. Contradicting the initial perception that RNAs were nonfunctional and that only…
Yang Zhao, Hongqi Teng, Fan Yao, Shannon Yap + 2 more
Long noncoding RNAs (lncRNAs) are involved in many physiological and pathological processes, such as development, aging, immunity, and cancer. Mechanistically, lncRNAs exert their functions through interaction with proteins, genomic DNA, and other RNA, leading to transcriptional and post-transcriptional regulation of…
Ken Nishikawa, Akira R. Kinjo
The epigenome, i.e., the whole of chromatin modifications, is transferred from mother to daughter cells during cell differentiation. When de novo chromatin modifications (establishment or erasure of, respectively, new or pre-existing DNA methylations and/or histone modifications) are made in a daughter cell, however…
Andoni Garitano-Trojaola, Xabier Agirre, Felipe Prósper, Puri Fortes
Long non-coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides in length. LncRNAs are as diverse as mRNAs and they normally share the same biosynthetic machinery based on RNA polymerase II, splicing and polyadenylation. However, lncRNAs have low coding potential. Compared to mRNAs, lncRNAs are…
Qais Ahmad Naseer, Abdul Malik, Fengyuan Zhang, Shengxia Chen
Long noncoding RNAs (lncRNAs), which are more than 200 nucleotides in length and do not encode proteins, play crucial roles in governing gene expression at both the transcriptional and posttranscriptional levels. These molecules demonstrate specific expression patterns in various tissues and developmental stages…
Esra GÜZEL TANOĞLU, Seyfure ADIGÜZEL, Alpaslan TANOĞLU, Zehra Betül AYDIN + 2 more
'Zehra Betül AYDIN' 'Gülizar HOCAOĞLU' 'Samet EBİNÇ'] Long noncoding RNAs (lncRNAs) are noncoding RNA molecules with a heterogeneous structure consisting of 200 or more nucleotides. Because these noncoding RNAs are transcribed by RNA polymerase II, they have properties similar to messenger RNA (mRNA). Contrary to…