20 papers · ranked by Valyu relevance
Haoran Ji, Chuang Hu, Xuhui Yang, Yuanhao Liu + 4 more
'Shengfang Ge' 'Xiansong Wang' 'Mingsong Wang'] Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune modulation, and secondary dissemination to distant sites through a series of mechanisms, and it has been proved that lymph node metastasis (LNM) is an essential prognostic indicator in many…
Marta Cakala-Jakimowicz, Paulina Kolodziej-Wojnar, Monika Puzianowska-Kuznicka, Juan Pablo de Rivero Vaccari
'Monika Puzianowska-Kuznicka' 'Juan Pablo de Rivero Vaccari'] Aging affects all tissues and organs. Aging of the immune system results in the severe disruption of its functions, leading to an increased susceptibility to infections, an increase in autoimmune disorders and cancer incidence, and a decreased response to…
Hannah den Braanker, Astrid C. van Stigt, Marc R. Kok, Erik Lubberts + 2 more
'Radjesh J. Bisoendial' 'Maria Luisa Balestrieri'] Lymphatic endothelial cells (LECs) line the lymphatic vasculature and play a central role in the immune response. LECs have abilities to regulate immune transport, to promote immune cell survival, and to cross present antigens to dendritic cells. Single-cell RNA…
Spyridon Makris, Charlotte M. de Winde, Harry L. Horsnell, Jesús A. Cantoral-Rebordinos + 2 more
'Jesús A. Cantoral-Rebordinos' 'Rachel E. Finlay' 'Sophie E. Acton'] Title: ABSTRACT Lymphoid tissue returns to a steady state once each immune response is resolved, and although this occurs multiple times throughout life, its structural integrity and functionality remain unaffected. Stromal cells orchestrate cellular…
Ann Ramirez, Vedanth Sriram, Yassmin Abbouchi, Reina Patolia + 3 more
Lymph nodes are highly specialized immune organs that orchestrate the adaptive immune response. In the lymph nodes, naïve B and T lymphocytes encounter cognate antigens, sparking their activation and response to foreign substances. Lymph nodes grow in response to an immune challenge, at least in part to accommodate…
Lara V. Graham, Salim I. Khakoo, Matthew D. Blunt, Vincent Vieillard
The lymph nodes are vital to enable adaptive immune responses to infection. Natural killer (NK) cells are cytotoxic lymphocytes that directly kill cancer cells and modulate the activation of other immune cells during anti-tumour immune response. NK cells in the lymph nodes are involved in the regulation of T-cell and…
Maddalena M Bolognesi, Lorenzo Dall’Olio, Giulio Eugenio Mandelli, Luisa Lorenzi + 7 more
Lymph nodes (LN) are key secondary lymphoid organs (SLO) for a coordinated immune response. They have been extensively characterized by numerous investigative techniques chiefly as single cell suspensions because they are composed of vagile yet crowded hematolymphoid elements, unfriendly to spatial tissue…
Diede Houbaert, Apostolos Panagiotis Nikolakopoulos, Odeta Meçe, Kathryn Jacobs + 15 more
Lymphatic endothelial cells (LECs) lining the lymphatic vessels of the lymph node (LN) parenchyma orchestrate leukocyte trafficking and peripheral T cell dynamics. T cell responses to immunotherapy largely rely on peripheral T cell recruitment in tumors. Yet, a systematic and molecular understanding of how LECs within…
Ke Yan, Dakai Jin, Dazhou Guo, Minfeng Xu + 4 more
'Xianghua Ye' 'Le Lü'] Abstract. Finding abnormal lymph nodes in radiological images is highly important for various medical tasks such as cancer metastasis staging and radiotherapy planning. Lymph nodes (LNs) are small glands scattered throughout the body. They are grouped or defined to various LN stations according…
David Bouget, André Pedersen, Johanna Vanel, Haakon Olav Leira + 1 more
'Thomas Langø'] Purpose: As lung cancer evolves, the presence of enlarged and potentially malignant lymph nodes must be assessed to properly estimate disease progression and select the best treatment strategy. Following the clinical guidelines, estimation of short-axis diameter and mediastinum station are paramount for…
Sofija Engelson, Jan Ehrhardt, Timo Kepp, Joshua Niemeijer + 1 more
Probabilistic Lymph Node Atlas Authors: ['Sofija Engelson' 'Jan Ehrhardt' 'Timo Kepp' 'Joshua Niemeijer' 'Heinz Handels'] | Engelson https://orcid.org/0009-0007-2493-8107 ∗ Sofija | sofija.engelson@uni-luebeck.de | | --- | --- | | Institute of Medical Informatics, University of L¨ubeck, L¨ubeck, Germany | | | ∗ Jan…
Junwu Xiong, Lanzhuju Mei, Jiameng Liu, Dinggang Shen + 2 more
on Contrast CT Images Authors: ['Junwu Xiong' 'Lanzhuju Mei' 'Jiameng Liu' 'Dinggang Shen' 'Zhong Xue' 'Xiaohuan Cao'] Abstract. Accurate lymph node detection and quantification are crucial for cancer diagnosis and staging on contrast-enhanced CT images, as they impact treatment planning and prognosis. However…
Yongrui Yu, Hanyu Chen, Zitian Zhang, Qiong Xiao + 7 more
Segmentation Authors: ['Yongrui Yu' 'Hanyu Chen' 'Zitian Zhang' 'Qiong Xiao' 'Wenhui Lei' 'Linrui Dai' 'Yu Fu' 'Tan Hui' 'Guan Wang' 'Peng Gao' 'Xiaofan Zhang'] Abstract. Despite the significant success achieved by deep learning methods in medical image segmentation, researchers still struggle in the computer-aided…
Andrew I. Morrison, Jonas Jäger, Charlotte M. de Winde, Henk P. Roest + 4 more
To study systemic human innate and adaptive immune responses in detail, competent in vitro lymph node (LN) models with LN stromal cells (LNSCs) are required to recapitulate the physiological microenvironment. The multicellular organisation of LNs possesses a challenge for designing such microphysiological systems…
Alexander J. Najibi, Ryan S. Lane, Miguel C. Sobral, Benjamin R. Freedman + 8 more
Lymph nodes (LNs) dynamically expand in response to immunization, but the relationship between LN expansion and the accompanying adaptive immune response is unclear. Here, we first characterized the LN response across time and length scales to vaccines of distinct strengths. High-frequency ultrasound revealed that a…
Morgan E. Brisse, Heather D. Hickman, Deepak Shukla
Many viruses induce viremia (virus in the blood) and disseminate throughout the body via the bloodstream from the initial infection site. However, viruses must often pass through the lymphatic system to reach the blood. The lymphatic system comprises a network of vessels distinct from blood vessels, along with…
Xin SU, Ariane Brassard, Alexandra Bartolomucci, Iqraa Dhoparee-Dooma + 16 more
Lymph nodes (LNs) are frequently the first sites of metastasis. Currently, the only prognostic LN assessment is determining metastasis status. However, there is evidence suggesting that LN metastasis is facilitated by a pre-metastatic niche induced by tumour derived extracellular vehicles (EVs). Therefore, it is…
Paul Schütz, Florian L. Schwarzenberg, Lennert J. Weber, Jörg U. Hammel + 11 more
This study identifies and characterizes previously unrecognized medullary B cell niches within murine mucosa-draining lymph nodes (LNs), challenging the conventional understanding of LN architecture. Utilizing advanced imaging techniques, including synchrotron radiation-based phase-contrast micro-computed tomography…
Authors not listed
Hodgkin’s lymphoma is a malignancy (cancer) that affects the immune system, primarily lymphocytes (white blood cells). CD30 is a protein receptor expressed on the surface of Hodgkin's cancer cells and is a crucial target for diagnosis and treatment. As of now, current CD30-targeted therapies come with extensive side…
Kazeem Olanrewaju, Ashlee N. Ford Versypt
The human physiological system consists of several biological units carefully organized to engage in a bio-physicochemical interaction with complex fluids transporting nutritional and life-supporting species (oxygen and carbon dioxide) needed for the proper functioning of the body. The nutritional species are products…