15 papers · ranked by Valyu relevance
Valerio Licursi, Federica Conte, Giulia Fiscon, Paola Paci
Background miRNAs regulate the expression of several genes with one miRNA able to target multiple genes and with one gene able to be simultaneously targeted by more than one miRNA. Therefore, it has become indispensable to shorten the long list of miRNA-target interactions to put in the spotlight in order to gain…
Simona Panni, Roberto Pizzolotto
Title: Simple Summary MicroRNAs are short RNA molecules performing crucial regulatory roles in human cells, making them an attractive target for synthetic drugs that can either replace or inhibit them. However, perturbing the microRNA network by enhancing or depleting a single miRNA often leads to unpredictable…
Jun-ichi Satoh
MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs, mediate posttranscriptional regulation of protein-coding genes by binding chiefly to the 3’ untranslated region of target mRNAs, leading to translational inhibition, mRNA destabilization or degradation. A single miRNA concurrently downregulates hundreds of…
Alexandra Drakaki, Dimitrios Iliopoulos
MicroRNAs are small non-coding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. They are involved in cellular development, differentiation, proliferation and apoptosis and play a significant role in cancer. Examination of tumor-specific microRNA expression profiles has revealed…
Jun-ichi Satoh, Hiroko Tabunoki
Background MicroRNAs (miRNAs) mediate posttranscriptional regulation of protein-coding genes by binding to the 3' untranslated region of target mRNAs, leading to translational inhibition, mRNA destabilization or degradation, depending on the degree of sequence complementarity. In general, a single miRNA concurrently…
Ricky Bhajun, Laurent Guyon, Amandine Pitaval, Eric Sulpice + 6 more
'Stéphanie Combe' 'Patricia Obeid' 'Vincent Haguet' 'Itebeddine Ghorbel' 'Christian Lajaunie' 'Xavier Gidrol'] MiRNAs are key regulators of gene expression. By binding to many genes, they create a complex network of gene co-regulation. Here, using a network-based approach, we identified miRNA hub groups by their close…
Young-Ji Na, Ju Han Kim
Background MicroRNAs (miRNAs) are key components in post-transcriptional gene regulation in multicellular organisms. As they control cooperatively a large number of their target genes, they affect the complexity of gene regulation. One of the challenges to understand miRNA-mediated regulation is to identify…
Elsi Ferro, Chiara Enrico Bena, Silvia Grigolon, Carla Bosia
MicroRNAs are short non-coding RNAs that are evolutionarily conserved and are pivotal post-transcriptional mediators of gene regulation. Together with transcription factors and epigenetic regulators, they form a highly interconnected network whose building blocks can be classified depending on the number of molecular…
Joseph J Nalluri, Bhanu K Kamapantula, Debmalya Barh, Neha Jain + 6 more
Background MicroRNAs (miRNAs) have increasingly been found to regulate diseases at a significant level. The interaction of miRNA and diseases is a complex web of multilevel interactions, given the fact that a miRNA regulates upto 50 or more diseases and miRNAs/diseases work in clusters. The clear patterns of miRNA…
Lun Li, Xingchi Hu, Zhaowan Yang, Zhenyu Jia + 3 more
'Libin Zhang' 'Yanhong Zhou'] Associating microRNAs (miRNAs) with cancers is an important step of understanding the mechanisms of cancer pathogenesis and finding novel biomarkers for cancer therapies. In this study, we constructed a miRNA-cancer association network (miCancerna) based on more than 1,000 miRNA-cancer…
Tânia Monteiro Marques, Margarida Gama-Carvalho, Alfredo Pulvirenti, Francisco Rodrigues Pinto + 1 more
'Francisco Rodrigues Pinto' 'Javier De Las Rivas'] microRNAs are small non-coding RNAs that play a key role in regulating gene expression. These molecules exert their function through sequence complementarity with microRNA responsive elements and are typically located in the 3′ untranslated region of mRNAs, negatively…
Simona Panni, Zihua Hu
A large fraction of the human genome is transcribed in RNA molecules that do not encode for proteins but that do have a crucial role in regulating almost every level of gene expression and, thus, define the specific phenotype of each cell. These non-coding RNAs include well-characterized microRNAs and thousands of…
Claudia Cava, Antonio Colaprico, Gloria Bertoli, Alex Graudenzi + 7 more
'Tiago C. Silva' 'Catharina Olsen' 'Houtan Noushmehr' 'Gianluca Bontempi' 'Giancarlo Mauri' 'Isabella Castiglioni' 'Li Lin'] Gene Regulatory Networks (GRNs) control many biological systems, but how such network coordination is shaped is still unknown. GRNs can be subdivided into basic connections that describe how the…
Andrea Riba, Carla Bosia, Mariama El Baroudi, Laura Ollino + 2 more
'Michele Caselle' 'Xianghong Jasmine Zhou'] It is well known that, under suitable conditions, microRNAs are able to fine tune the relative concentration of their targets to any desired value. We show that this function is particularly effective when one of the targets is a Transcription Factor (TF) which regulates the…
Anton Fliri, Ron Sostek, Shama Kajiji
Well-being depends on the integrated operation of biological processes at all levels of system organization, from individual cells to tissues and organ systems, collectively sustaining homeostasis and optimal bodily functions. The regulation of cooperation among these processes is mediated by information flow within…