18 papers · ranked by Valyu relevance
Robert A. Szczepaniak Sloane, Michael G. White, Russell G. Witt, Anik Banerjee + 20 more
'Anik Banerjee' 'Michael A. Davies' 'Guangchun Han' 'Elizabeth Burton' 'Nadim Ajami' 'Julie M. Simon' 'Chantale Bernatchez' 'Lauren E. Haydu' 'Hussein A. Tawbi' 'Jeffrey E. Gershenwald' 'Emily Keung' 'Merrick Ross' 'Jennifer McQuade' 'Rodabe N. Amaria' 'Khalida Wani' 'Alexander J. Lazar' 'Scott E. Woodman' 'Linghua…
Panni Simona, Kalpana Panneerselvam, Pablo Porras, Margaret Duesbury + 4 more
In recent years, a huge amount of data on ncRNA interactions has been described in scientific papers and databases. Although considerable effort has been made to annotate the available knowledge in public repositories, there are still significant discrepancies in how different resources capture and interpret data on…
Simona Panni, Roberto Pizzolotto
Title: Simple Summary MicroRNAs are short RNA molecules performing crucial regulatory roles in human cells, making them an attractive target for synthetic drugs that can either replace or inhibit them. However, perturbing the microRNA network by enhancing or depleting a single miRNA often leads to unpredictable…
Simona Panni, Kalpana Panneerselvam, Pablo Porras, Margaret Duesbury + 4 more
In recent years, a huge amount of data on ncRNA interactions has been described in scientific papers and databases. Although considerable effort has been made to annotate the available knowledge in public repositories, there are still significant discrepancies in how different resources capture and interpret data on…
Meredith Hill, Sarah Stapleton, Phuong Thao Nguyen, Dayna Sais + 4 more
MicroRNAs (miRNA, miRs) are small noncoding RNAs that are ubiquitously expressed in all mammalian cells. Their primary function is the regulation of nascent RNA transcripts by direct binding to regions on the target. There is now exciting data to suggest that these miRNAs can bind to other miRNAs, and this may have a…
Simona Panni, Zihua Hu
A large fraction of the human genome is transcribed in RNA molecules that do not encode for proteins but that do have a crucial role in regulating almost every level of gene expression and, thus, define the specific phenotype of each cell. These non-coding RNAs include well-characterized microRNAs and thousands of…
Junpeng Zhang, Lin Liu, Xuemei Wei, Chunwen Zhao + 3 more
RNA-sequencing technology provides an effective tool for understanding miRNA regulation in complex human diseases, including cancers. A large number of computational methods have been developed to make use of bulk and single-cell RNA-sequencing data to identify miRNA regulations at the resolution of multiple samples…
Seonwoo Min, Byunghan Lee, Sungroh Yoon
Motivation: MicroRNAs (miRNAs) play pivotal roles in gene expression regulation by binding to target sites of messenger RNAs (mRNAs). While identifying functional targets of miRNAs is of utmost importance, their prediction remains a great challenge. Previous computational algorithms have major limitations. They use…
Zhesi Zhang, Xin Lai
MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level, yet interpreting their function at the pathway level remains challenging. Existing enrichment analysis tools predominantly adopt network node-centric approaches that focus on gene expression profiles, neglecting the regulatory information…
Dietrich Kong, Ke Wang, Qiuning Zhang, Zhitong Bing
MicroRNAs play an indispensable role in numerous biological processes ranging from organismic development to tumor progression. In oncology, these microRNAs constitute a fundamental regulation role in the pathology of cancer that provides the basis for probing into the influences on clinical features through…
Anton Fliri, Ron Sostek, Shama Kajiji
Well-being depends on the integrated operation of biological processes at all levels of system organization, from individual cells to tissues and organ systems, collectively sustaining homeostasis and optimal bodily functions. The regulation of cooperation among these processes is mediated by information flow within…
Karen Guerrero‐Vázquez, Jacopo Umberto Verga, Pilib Ó Broin, Éva Szegezdi + 1 more
- 1 School of Mathematical and Statistical Sciences, University of Galway, Galway, Ireland. - 2 Galway RNA Research Cluster, University of Galway, Galway, Ireland. - 3 Centre for Research Training in Genomics Data Science, University of Galway, Galway, Ireland. - 4 Apoptosis Research Centre, University of Galway…
Hirotake Udono, Minzhi Fan, Yoko Saito, Hirohisa Ohno + 4 more
Programmable droplets, artificial liquid-like condensates of nucleic acids, are intelligent out-of-equilibrium systems that allow the critical aspects of their biological counterparts to be harnessed programmably, such as molecular sensing and phase-state change. While DNA has been central to the previous efforts, less…
Priya Chakraborty, Sayantari Ghosh
MicroRNAs are extensively known for post-transcriptional gene regulation and pattern formation in the embryonic developmental stage. We explore the origin of these spatio-temporal patterns mathematically, considering three different motifs here. For three scenarios, (1) simple microRNAbased mRNA regulation with a…
Authors not listed
Active assembly of matter is a defining trait of living systems, enabling the creation of far-from-equilibrium materials essential for the functionality of life. This is achieved through energy-dissipative, multi-step processes facilitated by various biomolecular agents for chemical and mechanical assembly of matter.…
Aarav Arora, Igor Tsigelny, Valentina Kouznetsova
Purpose Laryngeal cancer (LC) is the most common head and neck cancer, which often goes undiagnosed due to the expensiveness and inaccessible nature of current diagnosis methods. Many recent studies have shown that microRNAs (miRNAs) are crucial biomarkers for a variety of cancers. Methods In this study, we create a…
Mariano E. Brito, Christian Holm
Microgels exhibit the ability to undergo reversible swelling in response to shifts in environmental factors that include variations in temperature, concentration, and pH. While several models have been put forward to elucidate specific aspects of microgel swelling and its impact on bulk behavior, a consistent…
Authors not listed
Background and Objectives: Major Depressive Disorder (MDD) is a mental disorder characterized by persistent feelings of sadness, loss of interest, and agitation. MDD is the leading cause of disability worldwide, yet it is still largely underdiagnosed due to misinterpretation of behavioral symptoms. Despite growing…