6 papers · ranked by Valyu relevance
Li Peng, Weisi Lai, Jian Huang, Yan Zhong
Early detection of preeclampsia with noninvasive and reliable biomarkers is the foremost step for minimizing adverse effects during pregnancy. However, none maternal serum analyte evaluated so far is sufficiently accurate to allow recommending their routine use. Microarray was used to first identify differentially…
Lena Trnovec, Miha Štajdohar, Gad Shaulsky, Blaž Zupan
dictyExpress 3.0 is a React/TypeScript reimplementation of the Dictyostelium discoideum transcriptomics web server, first introduced in 2009, that unifies bulk and single-cell exploration. A long-standing gene-expression resource for the Dictyostelium community, dictyExpress is also accessible through dictyBase, the…
Shangru Jia, Artem Lysenko, Keith A Boroevich, Alok Sharma + 1 more
Prognostic stratification in multiple myeloma (MM) relies on staging systems fixed at diagnosis, discarding temporal information accumulated during treatment. We developed a dynamic multimodal framework that predicts residual overall survival from observation windows of 1-18 months post-diagnosis. The model integrates…
Arnaud Fernandez, Philippe Auby, Boris Chaumette, Gaelle Laure + 2 more
Childhood-onset schizophrenia (COS) is a rare (1/10 000) and severe disorder starting before the age of 13 and characterised by substantially higher rates of neurocognitive impairment and pathogenic genetic variants than adult-onset schizophrenia (AOS).[1], [2] This biological severity is mirrored by profound clinical…
Florian Köhler, Anna Delgado-Tejedor, Maik Zehnsdorf, Marisol Salgado Albarran + 5 more
Short-read sequencing-based single-cell transcriptomics represents the current gold standard for studying cellular transcriptomes but remains limited in its ability to resolve full-length transcript isoforms and splicing patterns. Long-read single-cell and single-nucleus RNA sequencing (LR sc/snRNA-seq) enables the…
Alejandro Espinoza, Bruno J. de Andrade Silva, Matteo Pellegrini
Single-cell RNA sequencing technologies provide insights into gene expression at the cellular level, enabling detailed analysis of cellular heterogeneity. In this study, we systematically compared two scRNA-seq platforms,10X Genomics and Parse Biosciences, using human peripheral blood mononuclear cells (PBMCs) and…