7 papers · ranked by Valyu relevance
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The capacity to pattern biomolecules within microfluidic devices expands the scope of microfluidic technologies. In such patterned systems, surface-bound components remained localized, while the microfluidic network supplies reagents and removes waste products. This approach has enabled continuous protein expression…
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During early-stage biotherapeutic development, analytical methods play an important role in candidate screening, process development, formulation screening and stability determination. However, developing sensitive and robust analytical methods is challenging in the early stages as there is often insufficient product…
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Understanding how plants respond to dynamic and spatially variable stimuli is a key goal in plant sciences. Traditional imaging methods often involve a trade-off between environmental control and spatial resolution, limiting their ability to capture real-time responses in high resolution. Microfluidic technology…
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Extreme weather events increasingly threaten coastal water quality, yet the mechanisms by which tropical cyclones impair microbial conditions remain poorly quantified. We develop a Large Language Model–Assisted Microbial Source Tracking (LAMST) framework to trace the origins of microbial threats—fecal indicator…
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mRNA-based technology has emerged as a new class of medicines with a wide range of applications, including viral vaccines, cancer vaccines, and therapeutics for the treatment of metabolic diseases and cardiovascular conditions. Impurities, including double-stranded RNA (dsRNA), mRNA fragments, and mRNA multimers…
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The process of label selection holds significant importance in the field of electrochemical biosensors, as it directly impacts the achievement of low detection limits and a wide dynamic range. To attain these objectives, it is necessary to take into account several aspects, including low electroactive potential, high…
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Quantitative analysis of small extracellular vesicles (sEVs) at single-particle resolution remains challenging due to their nanoscale dimensions and compositional heterogeneity. Existing methods often rely on specialized and costly instrumentation, limiting accessibility for many researchers and necessitates extensive…