15 papers · ranked by Valyu relevance
Greg Gibson
Microarrays can survey genome-wide expression patterns. Not only can these gene expression profiles be used to identify a few genes of interest, they are now being creatively applied for hypothesis generation and testing
Donna K. Slonim, Itai Yanai, Olga G. Troyanskaya
There are many commercial packages for microarray analyses, and we have by no means evaluated all of them. However, commercial tools can be expensive, and we find many that we have tried to have limited flexibility. Fortunately, in the past few years a number of Web-based tools and open-source software packages for…
Roman Jaksik, Marta Iwanaszko, Joanna Rzeszowska-Wolny, Marek Kimmel
Oligonucleotide microarrays belong to the basic tools of molecular biology and allow for simultaneous assessment of the expression level of thousands of genes. Analysis of microarray data is however very complex, requiring sophisticated methods to control for various factors that are inherent to the procedures used. In…
Michael Maurer, Robert Molidor, Alexander Sturn, Juergen Hartler + 5 more
'Hubert Hackl' 'Gernot Stocker' 'Andreas Prokesch' 'Marcel Scheideler' 'Zlatko Trajanoski'] Background Microarray analysis has become a widely used technique for the study of gene-expression patterns on a genomic scale. As more and more laboratories are adopting microarray technology, there is a need for powerful and…
Robert Klopfleisch, Achim D. Gruber
In recent years several technologies for the complete analysis of the transcriptome and proteome have reached a technological level which allows their routine application as scientific tools. The principle of these methods is the identification and quantification of up to ten thousands of RNA and proteins species in a…
Yilin Dai, Ling Guo, Meng Li, Yi-Bu Chen
Background Microarray data analysis presents a significant challenge to researchers who are unable to use the powerful Bioconductor and its numerous tools due to their lack of knowledge of R language. Among the few existing software programs that offer a graphic user interface to Bioconductor packages, none have…
Aristotelis Chatziioannou, Panagiotis Moulos, Fragiskos N Kolisis
Background The microarray data analysis realm is ever growing through the development of various tools, open source and commercial. However there is absence of predefined rational algorithmic analysis workflows or batch standardized processing to incorporate all steps, from raw data import up to the derivation of…
Lihua Ying, Minnie Sarwal
Microarray technologies have both fascinated and frustrated the transplant community since their introduction roughly a decade ago. Fascination arose from the possibility offered by the technology to gain a profound insight into the cellular response to immunogenic injury and the potential that this genomic signature…
Pratik Jaluria, Konstantinos Konstantopoulos, Michael Betenbaugh, Joseph Shiloach
'Joseph Shiloach'] With advances in robotics, computational capabilities, and the fabrication of high quality glass slides coinciding with increased genomic information being available on public databases, microarray technology is increasingly being used in laboratories around the world. In fact, fields as varied as…
Argyris Tzouvelekis, George Patlakas, Demosthenes Bouros
Microarrays are a powerful tool that have multiple applications both in clinical and cell biology arenas of common lung diseases. To exemplify how this tool can be useful, in this review, we will provide an overview of the application of microarray technology in research relevant to common lung diseases and present…
Carole L Yauk, M Lynn Berndt
DNA microarray technologies are used in a variety of biological disciplines. The diversity of platforms and analytical methods employed has raised concerns over the reliability, reproducibility and correlation of data produced across the different approaches. Initial investigations (years 2000-2003) found discrepancies…
Bernhard Y Renard, Martin Löwer, Yvonne Kühne, Ulf Reimer + 4 more
'Andrée Rothermel' 'Özlem Türeci' 'John C Castle' 'Ugur Sahin'] Background Peptide microarrays offer an enormous potential as a screening tool for peptidomics experiments and have recently seen an increased field of application ranging from immunological studies to systems biology. By allowing the parallel analysis of…
Bin Wang, Yaguang Xi
Microarray is a high throughput discovery tool that has been broadly used for genomic research. Probe-target hybridization is the central concept of this technology to determine the relative abundance of nucleic acid sequences through fluorescence-based detection. In microarray experiments, variations of expression…
Chandra K. Dixit, Gerson R. Aguirre
Microfluidic-based micromosaic technology has allowed the pattering of recognition elements in restricted micrometer scale areas with high precision. This controlled patterning enabled the development of highly multiplexed arrays multiple analyte detection. This arraying technology was first introduced in the beginning…
Tom Boonefaes, Erica Houthuys, Rafael Van den Bergh, Seppe Vander Beken + 4 more
'Seppe Vander Beken' 'Geert Raes' 'Peter Brouckaert' 'Patrick De Baetselier' 'Johan Grooten'] Background Research involving gene expression profiling and clinical applications, such as diagnostics and prognostics, often require a DNA array platform that is flexibly customisable and cost-effective, but at the same time…