13 papers · ranked by Valyu relevance
Jard H. de Vries, Daniel Kling, Athina Vidaki, Pascal Arp + 6 more
Single nucleotide polymorphism (SNP) data generated with microarray technologies have been used to solve murder cases via investigative leads obtained from identifying relatives of the unknown perpetrator included in accessible genomic databases, referred to as investigative genetic genealogy (IGG). However, SNP…
Alina Frolova, Vladyslav Bondarenko, Maria Obolenska
According to major public repositories statistics an overwhelming majority of the existing and newly uploaded data originates from microarray experiments. Unfortunately, the potential of this data to bring new insights is limited by the effects of individual study-specific biases due to small number of biological…
Luca Visentin, Luca Munaron, Federico Alessandro Ruffinatti
Tens of thousands of gene expression data sets describing a variety of model organisms in a many different pathophysiological conditions are currently stored in publicly available databases such as Gene Expression Omnibus (GEO) and ArrayExpress. As microarray technology is giving way to RNA-Seq, it becomes strategic to…
Ernur Saka, Benjamin J. Harrison, Kirk West, Jeffrey C. Petruska + 1 more
Since the introduction of microarrays in 1995, researchers world-wide have used both commercial and custom-designed microarrays for understanding differential expression of transcribed genes. Public databases such as ArrayExpress and the Gene Expression Omnibus (GEO) have made millions of samples readily available. One…
Majid Mohammadi, Hossein Sharifi Noghabi, Ghosheh Abed Hodtani, Habib Rajabi Mashhadi
One of the central challenges in cancer research is identifying significant genes among thousands of others on a microarray. Since preventing outbreak and progression of cancer is the ultimate goal in bioinformatics and computational biology, detection of genes that are most involved is vital and crucial. In this…
Preston Raab, W. Evan Johnson, Stephen R. Piccolo
Precision medicine relies on accurate and generalizable predictions for patients across the spectrum of human diversity. Because capturing biological heterogeneity requires large sample sizes, researchers must often aggregate data from several experimental batches or independent studies. This integration allows for…
Chin Hong Ooi, Nam-Trung Nguyen, Gregor Kijanka
Protein arrays are systematically arranged, large collections of annotated proteins on planar surfaces commonly used for the characterisation of protein binding events against a wide range of possible probes. These may include analyses of protein-protein, peptide-protein, enzyme-substrate or antibody-antigen…
Aarav Arora, Igor Tsigelny, Valentina Kouznetsova
Purpose Laryngeal cancer (LC) is the most common head and neck cancer, which often goes undiagnosed due to the expensiveness and inaccessible nature of current diagnosis methods. Many recent studies have shown that microRNAs (miRNAs) are crucial biomarkers for a variety of cancers. Methods In this study, we create a…
Kazi Ferdous Mahin, Md. Robiuddin, Mujahidul Islam, Shayed Ashraf + 2 more
Cancer is one of the major causes of human death per year. In recent years, cancer identification and classification using machine learning have gained momentum due to the availability of high throughput sequencing data. Using RNA-seq, cancer research is blooming day by day and new insights of cancer and related…
Authors not listed
Terminally labeled DNA oligonucleotides have wide applications in modern biology and biotechnological applications. It has been observed that the fluorescent intensity of light released from these fluorescent labels is heavily influenced by the terminal sequence of nucleotides. Recent studies have assayed and published…
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Microarrays are widely used for detecting target analytes and biomarkers, with fabrication methods ranging from non-contact to contact bioprinting techniques. Microcontact bioprinting (μCP), which utilizes elastomeric stamps to transfer biorecognition molecules (bioinks) onto substrates, offers advantages such as…
Shadman Khan, Amid Shakeri, Jonathan Monteiro, Simrun Tariq + 5 more
With both foodborne illness and food spoilage detrimentally impacting human health and the economy, there is growing interest in the development of in situ sensors that offer real-time monitoring of food quality within enclosed food packages. While oligonucleotide-based fluorescent sensors have illustrated significant…
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Large-scale de novo nucleic acid synthesis is a powerful tool enabling researchers to better understand and engineer biological systems. Fields ranging from genomics to nucleic acid therapeutics to synthetic biology make use of high-throughput experimental approaches requiring access to large pools or libraries of DNA…