3 papers · ranked by Valyu relevance
Wenbin Li, Rui Fan, Kun Xie, Jiehua Zhong + 12 more
EV-miRNAs are promising gastric cancer (GC) biomarkers for early diagnosis, yet their clinical application is limited by major detection challenges arising from the low abundance and high sequence homology of EV-miRNAs. Herein, we developed a dual-mode platform for sensitive EV-miRNA in situ profiling based on…
Shangru Jia, Artem Lysenko, Keith A Boroevich, Alok Sharma + 1 more
Prognostic stratification in multiple myeloma (MM) relies on staging systems fixed at diagnosis, discarding temporal information accumulated during treatment. We developed a dynamic multimodal framework that predicts residual overall survival from observation windows of 1-18 months post-diagnosis. The model integrates…
Md Shafayet Hossain, Yi-Ping Phoebe Chen
Non-coding RNAs (ncRNAs), once considered genomic dark matter, are now established as key regulators of gene expression with widespread roles in cellular homeostasis and disease. In cancer, ncRNA expression is frequently and systematically dysregulated, and many of these molecules circulate in stable, protected form…