15 papers · ranked by Valyu relevance
Suyi Zhang, Jin Shan, Shiya Lv, Yu Liu + 10 more
High-resolution, multi-modal neural interfaces are essential for advancing systems neuroscience and brain-computer interface technologies. This study designed and fabricated a 128-channel comb-shaped flexible micro-electrode array. The device integrates a biocompatible Parylene substrate with a flexible thin-film…
Mieczyslaw Korolczuk, Mateusz Ochab, Iwona Gęca
The article reports for the first time the application of a solid silver microelectrode array for the anodic stripping voltammetric determination of thallium(I) ions (Tl(I)). The microelectrode properties of the presented sensor were tested. The proposed solid metal microelectrode array is characterized by its…
Mingda Zhao, Yuxing Zhang, Yibo Wang, Hui Liu + 4 more
Brain-on-a-chip (BOC) refers to a miniaturized in vitro platform that integrates living neuronal networks on a micro-engineered chip, enabling the simulation of brain functions, neural activities and physiological responses. BOC technology is an advanced evolution of microphysiological systems (MPS) and Lab-on-a-Chip…
Adam M Forrest, Nicolas G Kunigk, Jennifer L Collinger, Robert A Gaunt + 3 more
Objective. Utah arrays are widely used in both humans and non-human primates (NHPs) for intracortical brain-computer interfaces, primarily for detecting electrical signals from cortical tissue to decode motor commands. Recently, these arrays have also been applied to deliver electrical stimulation aimed at restoring…
Daniel P. Woods, Grace M. Adams, Rana Mozumder, Wenhao Dang + 3 more
Title: SUMMARY Neurophysiological recordings from non-human primates (NHPs) have traditionally relied on rigid microelectrode arrays made from stainless steel or silicon. While these devices enable high-quality recordings, a fundamental mechanical mismatch between rigid materials and soft brain tissue leads to…
Jizhi Liang, Xiner Wang, Zhaohan Chen, Xiaoling Wei + 5 more
Flexible neural interfaces capable of monitoring subcortical neuronal activity facilitate the study of deep brain neural circuits and their interactions with the cortex. However, there exists a paucity of translational tools for interfacing subcortical nuclei surfaces within the intraventricular cerebrospinal fluid.…
Eunyoung Jang, Saewoon Shin, Seul‐Gi Lee, Kiup Kim + 7 more
Real-time, non-destructive monitoring of electrophysiological dynamics of 3D organoids is imperative for advancing disease modeling and high-throughput drug screening. However, obtaining continuous, reliable signals remains difficult due to the destructive nature of penetrating probes and the unreliable contact issue…
Qinghua Wu, Yan Gong, Xiang Liu, Nam-Trung Nguyen + 2 more
High-density microelectrode arrays (HDMEAs) have become increasingly important tools in neuroscience and biomedical engineering because of their high spatial and temporal resolution for recording and modulating electrical activity across diverse biological systems. Initially developed for in vitro studies of cultured…
Mieczyslaw Korolczuk, Mateusz Ochab, Iwona Gęca
The present study reports the application of a gold microelectrode array to determine copper(II) ions by anodic stripping voltammetry (ASV). The microelectrode characterization of the presented working electrode was investigated. Moreover, the way of its preparation ensures its reusability and eco-friendly character…
Zabir Ahmed, Ibrahim Kimukin, Vishal Jain, Kate Gurnsey + 2 more
Understanding brain function and developing effective neurotherapeutics require high-resolution electrophysiologyical recording across large primate brains. To achieve this goal, minimally invasive, compact, long, and high-density implantable neural probes are needed. Conventional silicon-based probes, designed for…
Wei Yao, Yueyue Li, Yuanyuan Meng, Xiaoling Pan + 3 more
The sustained reliability of invasive brain-computer interface (BCI) electrodes is fundamentally constrained by progressive interface destabilization, a process driven by the dynamic foreign body response (FBR). Given the intricate, time-dependent evolution of the FBR, the establishment of long-term stable neural…
Jack Maughan, Ian Woods, Cian O'Connor, Pablo Quintana‐Sarti + 9 more
Neural interfacing materials must deliver exceptional electrochemical performance, while integrating safely with the central nervous system. In this study we develop PolyGraph, a flexible, conductive, and biocompatible graphene-polycaprolactone (PCL) nanocomposite designed to strike this balance, which enables…
Szu-Ying Li, Yun-Ting Kuo, Sheng-Huang Lin, Shun-An Kan + 6 more
Neural function emerges from the interplay between electrical activity and neurochemical signaling, yet most implantable neural interfaces primarily record electrophysiological signals and lack molecular specificity for neurotransmitter monitoring. Here, we developed a flexible multimodal neural probe integrating an…
Christopher L. Frewin, Matthew Melton, Evans Bernardin, Mohammad Beygi + 3 more
The promise of intracortical neural interfaces-to restore lost sensory and motor function and probe the brain’s activity-has long been constrained by device instability over chronic implantation. Conventional silicon-based probes, composed of heterogeneous materials, often fail due to mechanical mismatch, inflammatory…
Minseong Hong, YeongSeok Ye, Joungwon Kim, Jae-Ick Kim + 2 more
Neural interface technologies stand at the threshold of a revolution, offering new possibilities for seamless, high-bandwidth interconnection between the human brain and computers. Recent progress has been driven by advances in microscale manufacturing, yielding sophisticated neural probes with diverse form factors…