22 papers · ranked by Valyu relevance
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Microgravity is proven to impact a wide range of human physiology, from stimulating stem cell differentiation to confounding cell health in bones, skeletal muscles, and blood cells. The research in this arena is progressively intensified by the increasing promises of human spaceflights. Considering the limited access…
Wei-Jia Sun, Rui-Kai Du, Yu-Heng Li, Guo-Hui Zhong + 6 more
With the advancement of manned spaceflight technology, significant progress has been made in the fields of aerospace medicine and space biology to address the needs of astronauts in terms of health, safety, and mission performance. The physiological and pathological changes during microgravity exposure, including…
Giovanni Marfia, Stefania Elena Navone, Laura Guarnaccia, Rolando Campanella + 11 more
'Rolando Campanella' 'Marco Locatelli' 'Monica Miozzo' 'Pietro Perelli' 'Giulio Della Morte' 'Leonardo Catamo' 'Pietro Tondo' 'Carmelo Campanella' 'Marco Lucertini' 'Giuseppe Ciniglio Appiani' 'Angelo Landolfi' 'Emanuele Garzia'] Title: Abstract Space environment provides many challenges to pilots, astronauts, and…
Stephen Lantin, Sophie Mendell, Ghassan Akkad, Alexander N. Cohen + 8 more
'Xander Apicella' 'Emma McCoy' 'Eliana Beltrán-Pardo' 'Michael Waltemathe' 'Prasanna Srinivasan' 'Pradeep M. Joshi' 'Joel H. Rothman' 'Philip Lubin'] Our ability to explore the cosmos by direct contact has been limited to a small number of lunar and interplanetary missions. However, the NASA Starlight program points a…
Marco Calvaruso, Carmelo Militello, Luigi Minafra, Veronica La Regina + 7 more
'Veronica La Regina' 'Filippo Torrisi' 'Gaia Pucci' 'Francesco P. Cammarata' 'Valentina Bravatà' 'Giusi I. Forte' 'Giorgio Russo' 'Fathi Karouia'] The rapid improvement of space technologies is leading to the continuous increase of space missions that will soon bring humans back to the Moon and, in the coming future…
Daniela Grimm
This Special Issue (SI), “Microgravity and Space Medicine 2.0”, comprises research articles on the research areas of gravitational biology, space medicine and molecular oncology. It covers studies investigating the effects of altered gravity conditions on poorly differentiated follicular thyroid cancer cells and…
William Dobney, Louise Mols, Dhruti Mistry, Kevin Tabury + 2 more
Ionizing radiation and microgravity are two considerable health risks encountered during deep space exploration. Both have deleterious effects on the human body. On one hand, weightlessness is known to induce a weakening of the immune system, delayed wound healing and musculoskeletal, cardiovascular, and sensorimotor…
Thomas Wareing, Alexander Stokes, Katrina Crompton, Koren Murphy + 6 more
With the European Space Agency (ESA) and NASA working to return humans to the moon and onwards to Mars, it has never been more important to study the impact of altered gravity conditions on biological organisms. These include astronauts but also useful micro-organisms they may bring with them to produce food, medicine…
Omer Luria, Mor Elgarisi, Valeri Frumkin, Alexey Razin + 8 more
'Jonathan D. Ericson' 'Khaled Gommed' 'Daniel Widerker' 'Israel Gabay' 'Ruslan Belikov' 'Jay A. Bookbinder' 'Edward P. Balaban' 'Moran Bercovici'] In the absence of gravity, surface tension dominates over the behavior of liquids. While this often poses a challenge in adapting Earth-based technologies to space, it can…
Thomas Wareing, Alexander Stokes, Katrina Crompton, Koren Murphy + 6 more
'Jack Dawson' 'Yusuf Furkan Ugurluoglu' 'Connor Richardson' 'Hongquan Li' 'Manu Prakash' 'Adam J. M. Wollman'] With the European Space Agency (ESA) and NASA working to return humans to the moon and onwards to Mars, it has never been more important to study the impact of altered gravity conditions on biological…
Sarika Hinge, Jyotsana Dixit, Pandit Vidyasagar, Gauri Kulkarni
Red blood cell is an important role model of microcirculation, gas exchange, drug carrier, and related diseases. There has been an increasing interest in understanding the biochemical and structural changes in Red blood cells (RBC) due to simulated microgravity conditions. In the present work, isolated human red blood…
Stephen Lantin, Mayur Bansal, Hal S. Alper, Jessica Audrey Lee
As human space exploration expands to the Moon, Mars, and beyond, there is a growing need to study the effects of altered gravity on the microbial systems that we will bring with us for life support. Because spaceflight experiment opportunities are rare and resource-intensive, most space biology experiments are…
Nilufar Ali, Shehbeel Arif, Max-Florian Mortimer, Matthew Brandner + 10 more
Spaceflight stressors may increase Parkinson’s disease (PD) risk, but microgravity’s specific contribution to human dopaminergic (DA) vulnerability remains undefined. Here, we exposed human iPSC-derived midbrain DA organoids and differentiated SH-SY5Y neurons to simulated microgravity for 72 hours. This exposure…
Michaela B. Smith, Hui Chen, Brian G. G. Oliver, Alexander Dietrich
Space travel presents multiple risks to astronauts such as launch, radiation, spacewalks or extravehicular activities, and microgravity. The lungs are composed of a combination of air, blood, and tissue, making it a complex organ system with interactions between the external and internal environment. Gravity strongly…
Xin Miao, Zhongrui You, Zihan Zhang, Taoran Jiang + 6 more
Collaboration in Microgravity Authors: ['Xin Miao' 'Zhongrui You' 'Zihan Zhang' 'Taoran Jiang' 'Tingjia Xu' 'Haotian Liang' 'Guojing Ge' 'Yuchen Ji' 'Shentong Mo' 'Jian Cheng'] We present SpaceAgents-1, a system for learning human and multi-robot collaboration (HMRC) strategies under microgravity conditions. Future…
Hang Luo, Nanlin Zhou, Haoxiang Zhang, Kai Han + 6 more
'Zhiyuan Yang' 'Jian Qi' 'Sikai Zhao' 'Jie Zhao' 'Yanhe Zhu'] Abstract—This study describes the development and validation of a novel microgravity experimental platform that is mainly applied to small robots such as modular self-reconfigurable robots. This platform mainly consists of an air supply system, a microporous…
Anirudh Murali, Ram Rup Sarkar
The growing interest in space exploration and human spaceflight has highlighted the critical challenges posed by microgravity on human physiology. One such challenge is the behavior of immune and red blood cells, which primarily rely on hematic or lymphatic streams (biofluids) for transport. This study aims to…
Leyla Loued‐Khenissi, Christian Pfeiffer, Rupal Saxena, Shivam Adarsh + 1 more
'Shivam Adarsh' 'Davide Scaramuzza'] Abstract—Does gravity affect decision-making? This question comes into sharp focus as plans for interplanetary human space missions solidify. In the framework of Bayesian brain theories, gravity encapsulates a strong prior, anchoring agents to a reference frame via the vestibular…
Cihan Tastan, Gamze Gulden, Ozge Demir, Ebru Cam + 5 more
Microgravity presents unique challenges to human physiology, particularly the immune system, during spaceflight. T lymphocytes, key components of adaptive immunity, play a vital role in immune regulation, yet the effects of microgravity on T-cell function and gene expression remain incompletely understood. This study…
David W. Jensen
As the space industry matures, large space stations will be built. This paper organizes and documents constraints on the size of these space stations. Human frailty, station design, and construction impose these constraints. Human limitations include gravity, radiation, air pressure, rotational stability, population…
A Akinosho, Z Benefield, B Willis, A Fritz + 2 more
Life on Earth evolved under a specific set of environmental conditions, including consistent gravitational and magnetic fields. However, planned human missions to Mars in the coming decades will expose terrestrial organisms to radically different conditions, with Martian gravity being approximately 38% of Earth’s and a…
Mohsen Farshad
Information and force definition has been intertwined with the concept of entropy for many years. The information for displacement of degrees of freedom with Brownian motions at a given temperature in space emerges as an entropic force between species. Here, we use this concept of entropy to understand the underlying…