9 papers · ranked by Valyu relevance
Nishan Shettigar, Ling-Qi Zhang, Jessica Teran, Luisa Schuster + 3 more
In the wild, a mouse must flexibly perform multiple computations at once, rapidly navigating, sampling its environment, forming and using memories, and balancing internal needs. Capturing the self-paced, low-repetition, complex nature of decision making in the wild while preserving the experimental control needed to…
Yosuke Arima, Zengyou Ye, Coleman B. Calva, Xia Min + 5 more
The supramammillary nucleus (SuM) is known to promote active, approach-oriented behaviors by engaging ventral tegmental area (VTA) dopamine neurons projecting to the nucleus accumbens (NAc), primarily via a glutamatergic SuM→medial septum (MS) pathway. However, the role of other SuM projections in this process remains…
Tetsuya Sasaki, Aki Takahashi, Yosuke Takei
RORγt, encoded by Rorc, is a lineage-defining regulator of T helper 17 (Th17) cell differentiation, and IL-17A signaling has been implicated in neurodevelopment and behavior. We characterized baseline behavioral phenotypes in male RORγt-transgenic mice with T-cell-biased RORγt overexpression and wild-type (WT)…
Guilin Wei, Zhuoan Jin, Hanying Mi, Nan Li + 5 more
Down-regulated O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) has been implicated in Parkinson’s disease (PD), and restoring O-GlcNAcylation levels in the central nervous system via O-GlcNAcase (OGA) suppression represents a potential therapeutic strategy for PD intervention. Nevertheless, naturally…
Megan Sholomiski, Victor Yon, Franziska Mudlaff, Aparna Suvrathan
The cerebellum supports a wide range of motor and non-motor behaviors, yet the specific cerebellar regions and neuronal populations underlying this functional diversity remain poorly understood. Here, we mapped patterns of immediate early gene activation in the cerebellar cortex during the accelerating rotarod task, an…
Yangjie Li, Yanqing Liu, Fei Gong, Kangling Xie + 6 more
This study presents a nanotherapeutic strategy for diabetic peripheral neuropathy (DPN) by developing polyimide-coated zeolitic imidazolate framework-8 core-shell nanovesicles loaded with interleukin-2 (MOF@PI-IL2) for inflammation-microenvironment-responsive delivery of IL-2 and relatively preferential activation of…
Stéphanie A. Eid, Andrew D. Carter, Emily J. Koubek, John M. Hayes + 7 more
Diabetic peripheral neuropathy (DPN), a severe complication of Type 2 diabetes (T2D), is marked by progressive distal-to-proximal axonal degeneration. Although animal models have advanced our understanding of DPN pathogenesis, preclinical successes rarely translate into effective therapies, underscoring the need for…
Fei-Fei Cheng, Hao Mou, Zhenyu Liu, Chang-Jun Zhang + 7 more
Title: Significance Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss among older adults and is projected to affect approximately 288 million people worldwide by 2040. Identifying the genes and cellular mechanisms underlying established AMD risk loci is essential for…
Ales Drobek, Maeva Delacrétaz, Aliki Vasilakou, Marta Monguió-Tortajada + 4 more
Title: Significance Systemic lupus erythematosus is a severe, complex, and heterogeneous autoimmune disease in which aberrant activation of endolysosomal nucleic acids sensing Toll-like receptors plays a central pathogenic role. The SLC15A4-TASL complex selectively activates inflammatory IRF5 signaling downstream of…