18 papers · ranked by Valyu relevance
Goulart, Paimon, Jordan Steinhauser, Kylene Shuler + 3 more
Integration of diverse data will be a pivotal step towards improving scientific explorations in many disciplines. This work establishes a vision-language model (VLM) that encodes videos with text input in order to classify various behaviors of a mouse existing in and engaging with their environment. Importantly, this…
Shida Zhou, Xiaoyu Wang, Yu Tian Wang
Introduction Huntington's disease (HD), a dominantly inherited neurodegenerative disorder caused by CAG repeat expansions in the HTT gene, manifests with progressive motor dysfunction, cognitive decline, and psychiatric disturbances. While current transgenic mouse models recapitulate key pathological features, they…
Caleb C. Vogt, Michael J. Sheehan
While the laboratory mouse is one of the most studied organisms on the planet, comparative research on the spatial and social structures of closely related Mus species remains limited. Here, we characterize the spatial, circadian, and social behavior of the Sikkim mouse (Mus pahari) wild-derived inbred strain PAH/Eij…
Martin Hindermann, Vinicius Daguano Gastaldi, Justus Wilke, Anja Ronnenberg + 3 more
Title: Summary The rapidly evolving field of rodent behavior research led to the development of the IntelliCage, enabling observer-independent experiments with mice. Here, we present a detailed protocol for IntelliCage-based automated cognitive profiling of mice that navigates users through all experimental steps. In…
Gideon A. Sarpong, Rachel Pass, Kavinda Liyanagama, Kang-Yu Chu + 5 more
Being able to switch from established choices to new alternatives when conditions change - behavioral flexibility - is essential for survival. Cholinergic signaling in the striatum contributes to such flexible behavior, yet the timing and spatial organization of acetylcholine release during contingency changes remain…
Georgia Lee Albrecht, Rebekah Ramirez, Delaram Moradpour, Jordan Mar + 4 more
Title: Summary Defensive behaviors such as freezing and escaping are crucial for survival, involving the complex integration of sensory and motor circuits. While instinctive, the ability to discern threat and adapt responsiveness is acquired through life experience, shaped by sensory maturation and emotional state.…
Samruddhi Deshpande, Roja Barik, Atharvaraj Hande, Richa Patel + 4 more
Endometriosis (ENDO) is an estrogen-dependent chronic gynaecological manifestation of uterine fragments attached outside of the uterus, accompanied by debilitating chronic pelvic pain. The evoked assays often employed fail to capture the subtle behavioral nuances in the mouse model. Thus, this study proposes…
Mohamed ElTabbal, Cedric Galetzka, Bernd Kuhn
Object interception requires integrating prediction and sensory feedback, making it a powerful model for studying sensorimotor transformations. However, traditional head-fixed mouse paradigms reduce behavior to stereotyped stimulus–response associations and lack key features of natural interception. To address this…
Justin Burdge, Anissa Jhumka, Ashar Khan, Simon Ogundare + 21 more
The canonical framework for testing pain and mechanical sensitivity in rodents is manual delivery of stimuli to the paw. However, this approach is time-consuming, produces variability in results, requires significant training, and is ergonomically unfavorable to the experimenter. To circumvent limitations in manual…
Marti Ritter, Serena Deiana, Alina Ritter, Carsten T. Wotjak + 2 more
The rapidly increasing number of video tracking-based behavioral summary tools and methods raises the question as to the most suitable approaches for pharmacological fingerprinting in pre-clinical research. We have recently shown that social context has a strong effect on behavioral syntax in mice, further suggesting…
Haoxuan Qi, Alice Treloar, Greg J. Stuart, Saba Gharaei
The capacity of animals to rapidly and appropriately respond to potential threats is critical for survival. In many species, this involves innate defensive behaviors, such as flight or freezing. However, not all threats are dangerous. Habituation allows animals to filter out irrelevant stimuli and avoid unnecessary…
Rafal Stryjek, Raffaele d’Isa, Michael H. Parsons, Karolina Szymańska + 4 more
When novel nutrient-rich food sources become available to species sharing the same natural habitat, interspecies competition may arise, yielding insights into the ecological and social dynamics of the observed species. Here, we investigated food consumption patterns, and consequent social interactions, by two sympatric…
Xiuzhi Dai, Yifan Wang, Takashi Yamaguchi, Michael Genecin + 5 more
Aggression is an innate behavior conserved across species, serving as a critical means to compete for food, mating opportunities, and other essential resources. A central question in aggression research is the extent to which inter-individual variability in aggression is shaped by genetic factors. Here, we examine…
Konstantin F. Willeke, Polina Turishcheva, Alex Gilbert, Goirik Chakrabarty + 17 more
Scaling data and artificial neural networks has transformed AI, driving breakthroughs in language and vision. Whether similar principles apply to modeling brain activity remains unclear. Here we leveraged a dataset of 3.1 million neurons from the visual cortex of 73 mice across 323 sessions, totaling more than 150…
Steffen Holter, Tobias Stähle, Arpit Narechania, Mennatallah El-Assady
The ability to automatically infer analytic intent from user interaction histories could enable interactive AI systems to proactively assist users during exploratory data analysis. In this paper, we examine whether provenance logs -- detailed records capturing sequences and timing of user interactions -- can be used to…
Kaiyue Shi, Christopher W. Lynn
In the brain, neural activity undergoes directed flows between states, thus breaking time-reversal symmetry. At the same time, animals also exhibit irreversible flows between behavioral states. Yet it remains unclear whether—and how—irreversibility in the brain relates to irreversibility in behavior. Here, we explore…
Authors not listed
For decades, molecular visualization software has been fundamental to education and research in chemistry, structural biology, and materials science. These tools have enabled the inspection of structures, dynamics, and interactions, yet their reliance on two-dimensional (2D) interfaces imposes persistent limitations.…
Eyrun Eyjolfsdottir, Kristin Branson
Understanding animal behavior at an algorithmic level -- what animals attend to, how they form internal models and plans, and how this maps to action -- remains a central challenge in neuroscience and ethology. Data-driven generative models offer a path toward this understanding. We introduce a framework for training…