10 papers · ranked by Valyu relevance
Yi Peng, Suobing Qin, Xiwen Li, Lijun Wan + 1 more
5## Conclusion This multi-omics study established metabolic reprogramming as the core regulatory mechanism for the progression of ccRCC, integrating the intrinsic metabolic changes of tumors with the reshaping of the external immune microenvironment. A robust prognostic prediction model was established and validated…
Ming Yu, Yumo Xie, Lena Allen, Kelly Carter + 10 more
{'content': 'Colorectal cancer develops through a normal-adenoma-carcinoma sequence, yet only 5-10% of adenomas progress to malignancy, and the cellular programs governing that sequence remain poorly defined. Here we generate a spatial multi-omics atlas of human colon adenomas, combining Visium CytAssist and protein…
Matheus da Silveira Costa, Henrique Izaias Marcelo, Gabriel Albanese Kafouri, Vinicius de Camargo
Colorectal cancer (CRC) is a major cause of cancer-related mortality, with distant metastasis strongly associated with poor clinical outcomes. Integrating transcriptomic and epigenomic data through machine learning may improve the molecular characterization of metastatic CRC. We analyzed 518 primary tumors from the…
Zhengyang Xue, Huiliang Xu, Ling Zhu, DeYu Zhao
Mycoplasma pneumoniae (MP) is one of the main pathogens causing atypical pneumonia in children. The susceptible population is mainly children and adolescents over 5 years old, and the infection rate has increased in recent years. At present, there is limited research on the pulmonary microbiota of patients with…
Jeremy Yuan-Sheng Leow, Nancy Choon-Si Ng, Rebecca Shin-Yee Wong, Long Chiau Ming + 2 more
Ovarian cancer (OC) remains difficult to detect at an early stage, and current screening approaches using CA125 and transvaginal ultrasonography have not demonstrated sufficient benefit for population screening. DNA methylation is a promising biomarker class because epigenetic alterations may arise early in…
Brett Kiyota, Chaehyeon Lee, Haoyang Yao, Nozomu Yachie
The rapid expansion of single-cell genomic datasets has led to the compilation of biological resources comprising hundreds of millions of cells across tissues, developmental stages, and disease states. This has underscored the need for scalable and interpretable data representations that preserve the complex…
Lena Trnovec, Miha Štajdohar, Gad Shaulsky, Blaž Zupan
dictyExpress 3.0 is a React/TypeScript reimplementation of the Dictyostelium discoideum transcriptomics web server, first introduced in 2009, that unifies bulk and single-cell exploration. A long-standing gene-expression resource for the Dictyostelium community, dictyExpress is also accessible through dictyBase, the…
E. Kashuk, A. Tarakanova, A. Malygina, N. Kuzovkina + 4 more
SIRT6 is a NAD^+^-dependent sirtuin that plays central roles in chromatin regulation, DNA repair, telomere maintenance, metabolic homeostasis, and inflammatory control. Although SIRT6 have long been implicated in aging because of its association with several hallmarks of aging, the available evidence remains largely…
Shangru Jia, Artem Lysenko, Keith A Boroevich, Alok Sharma + 1 more
Prognostic stratification in multiple myeloma (MM) relies on staging systems fixed at diagnosis, discarding temporal information accumulated during treatment. We developed a dynamic multimodal framework that predicts residual overall survival from observation windows of 1-18 months post-diagnosis. The model integrates…
Florian Borse, Silvana Lord Smits, T. Anthony Sun, Johannes Cairns + 2 more
Previous research in microbes successfully predicted biculture growth based on monoculture growth curves. Still, the usual model-based approach does not seem to extend to communities involving more than two bacterial strains. Here, we use a model-blind machine-learning approach to predict community-wide yield, area…