12 papers · ranked by Valyu relevance
Linsui Deng, Kejun He, Xianyang Zhang
Mendelian randomization (MR) has been widely used to infer causal relationships between exposures and outcomes in epidemiological studies. However, classical MR assumptions can be violated when genetic variants are associated with outcomes through pathways other than the exposure, leading to uncorrelated and/or…
Birthe Wenking, Alexander Reiterer, Knut Möller
Autonomy is a growing trend in robot-assisted minimally invasive surgery. Autonomous systems require geometric information about the surgical environment, obtained from images and 3D reconstruction. The long-term goal of this work is to improve the completeness of endoscope-based 3D reconstruction by first creating a…
Yuesong Wu, Haohao Su, Yuehua Cui
Cell-cell communication (CCC) is essential for maintaining tissue organization and driving biological progression, yet its inference from transcriptomic data has long been limited by the absence of spatial context. Advances in spatial transcriptomics (ST) now enable mechanistically grounded analyses of CCC by…
Odin Zhang, Jiaqi Wang, Tuscan Rock Thompson, Ziyi You + 3 more
Biomolecular interactions, including protein–protein interactions, protein–nucleic acid recognition, and protein–small molecule binding, underlie a wide range of biological processes and therapeutic mechanisms. Although recent de novo design methods can generate candidate binders for diverse molecular targets…
Huihai Wu, Ashleigh Lister, Iain Macaulay, Katie Long + 10 more
Single-cell and spatial transcriptomics are transforming our understanding of cellular heterogeneity and tissue organization, yet their analytical complexity remains a major bottleneck. Here, we present EISCA and EISTA, two standardized, end-to-end pipelines for single-cell RNA- seq and imaging-based spatial…
Stan Oome, Mohammad Ghanbari
Allelic heterogeneity is a term from genetics which means that alleles that differ in primary sequence can have a similar phenotypic outcome. In other words, they are functional equivalents, and they naturally appear through convergent evolution under selection. Current GWAS has trouble detecting these instances, as…
Mohamed Selmy, A. Abdulnabi, A. A. Ali, E. M. Saied + 1 more
Nanogrids have emerged as a crucial solution for contemporary residential power systems, providing a robust framework for integrating distributed energy resources (DERs), comprising solar photovoltaics (PVs), wind turbines (WTs), energy storage systems (ESSs), and diesel generators (DGs). However, the uncertainty of…
Tie-Qiang Mao, Xiaoyun Yang, Zhi-Cong He, Jiawen Yang + 6 more
Complete ammonia oxidizers (comammox) are widespread nitrifiers that can dominate ammonia oxidation in diverse environments by efficiently converting ammonia to nitrate within a single cell, yet the molecular basis distinguishing their ammonia monooxygenase (AMO) from those of canonical bacterial AMO remains…
Peng Wang, Zixiong Fan, Haoyu Wu, Kaijiao Wang + 4 more
Accurate preoperative segmentation of colorectal cancer lymph node metastasis holds significant clinical value for formulating individualized surgical strategies. However, accurate segmentation remains a formidable challenge due to the complex backgrounds, small sizes, irregular shapes, and indistinct boundaries…
Jackie Rao, Muntadher Jihad, Giulia Biffi, Paul D.W. Kirk
Identifying cell types from single-cell RNA sequencing (scRNA-seq) data typically requires several separate and often uninterpretable steps: dimensionality reduction, batch-correction, clustering, marker-gene identification and the discovery of finer-grained structure. Here we introduce scFLAME (single-cell Factor…
Peter Gill, Helen Johannessen, Christine Børsum, Ane Elida Fonneløp + 1 more
DNA findings on clothing are often evaluated at sub-source level to address whether a person contributed DNA to a sample. In many cases, however, the disputed issue is not whose DNA is present, but how the DNA was transferred. This paper applies the HaloGen framework to evaluate DNA findings on stockings under…
Xiao Hu, Run Ouyang, Zhuhao Shi, Wanqiong Tao + 4 more
Magnetic actuation provides an effective means for tetherless control of microrobots in complex environments. Inspired by the morphology and interfacial flotation mechanism of water striders, we design a four-legged microrobot with small ribs on its feet to mimic the structure of water striders. Through an asymmetric…