7 papers · ranked by Valyu relevance
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric + 7 more
Neoadjuvant chemoradiotherapy followed by total mesorectal excision is standard for locally advanced rectal cancer, but response varies and current markers are insufficient. This study integrates public bulk RNA-seq data to identify predictive features of response. TRIM54 and PABPC4 were upregulated in the responder…
Manuel Weber, Leah Trumet, Fabienne Lange, Julia Murk + 8 more
Purpose Combination immunotherapy has shown encouraging activity across multiple solid tumors. We report the complete and consecutive cohort of patients with locally advanced oral squamous cell carcinoma (OSCC) treated at a single center within the prospective, multicenter, randomized phase 2 BelieveIT-201 trial…
Ana Perpar, Petra Georg, Ajra Secerov Ermenc
Background Colorectal cancer is a common malignancy. Advancements in multimodality treatment have improved outcomes. About 2-10% of patients will have a local recurrence even after optimal treatment. Salvage surgical treatment is the treatment of choice, however, in posterior and lateral recurrences, surgery is linked…
Wei Wang, Yeaji Kim, Xiaotong Zhao, Kristen Weber Bonk + 3 more
Triple-negative breast cancer (TNBC) tumors lack expression of estrogen receptor (ER), progesterone receptor (PR), and HER2, limiting the availability of targeted therapeutic options. As a result, TNBC is characterized by a high propensity for metastasis, rapid recurrence, and poor overall prognosis. Despite…
Iuliia Taskaeva, Anna Kasatova, Timofey Bykov, Vladimir Richter + 3 more
Boron neutron capture therapy (BNCT) is one of the promising treatment methods for cancer. BNCT is based on the unique high ability of the non-radioactive boron-10 (^10^B) nucleus to absorb thermal neutrons. The absorption of a neutron by boron results in a nuclear reaction ^10^B(n,α)^7^Li with 84% of the energy being…
Hamad S. Alyami, Nora A. Ahmadi
Background: Systemic toxicity, poor drug selectivity, treatment resistance, and inconsistent tumor responses are some of the therapeutic issues related to thyroid cancer (TC). Chitosan-based nanoparticles (ChNPs) have shown promise as nanocarriers for target drug delivery due to their mucoadhesive qualities…
Federico Vannuccini, Yari Ciani, Vera Mugoni, Orsetta Quaini + 20 more
Circulating analytes in cancer patients capture tumor-related signals. We profiled matched extracellular vesicle (EV) total RNA and cell-free DNA (cfDNA) from the same plasma aliquots of chemo-naive metastatic castration-resistant prostate cancer (mCRPC) patients treated with Enzalutamide (n=54 patients, n=119…