12 papers · ranked by Valyu relevance
Justina Stark, Christophe Godin
Biological transport networks range from tree-like to highly reticulated architectures, which have been proposed to reflect different balances between viscous dissipation and metabolic cost. This balance cannot currently be inferred from structure: available descriptors either discard edge width entirely or preserve it…
Justin D Shin, Michael Satchell, Paul Miller, Shantanu P Jadhav + 2 more
REM (rapid eye movement) and non-REM (NREM) sleep stages contribute to systems memory consolidation in hippocampal-cortical circuits. However, the physiological mechanisms underlying REM memory processes remain relatively unclear compared to NREM memory reactivation. Here we report, in rodents, the existence of…
Giulia de Meijere, Andrea Pugliese, Gerardo Iñiguez, Péter L. Simon + 1 more
Contact tracing is one of the most important control measures deployed during epidemics and pandemics, relying on the identification of contacts of known infected individuals. A network perspective is therefore essential for its accurate modelling. Pairwise models have been used extensively to study contact tracing…
Yi Ren, Zimei Chen, Hayden Deans, Ying Nian Wu + 1 more
Extensive studies suggest the brain performs Bayesian inference to infer the latent world states. It is a fundamental neuroscience question that how canonical recurrent neural circuits in the brain implement Bayesian inference. Many existing theoretical studies focused on how the recurrent circuits compute the…
Raphael Mostov, Greyson Lewis, Gabriel Sturm, Wallace F. Marshall
This paper addresses the increasing need for comprehensive mathematical descriptions of cell organization by examining the algebraic structure of mitochondrial network dynamics. Mitochondria are cellular structures involved in metabolism that take the form of a network of membrane-based tubes that undergo continuous…
Eliezer Masliah
How transient neural representations become integrated and stable enough to function as internal neural models remains incompletely understood. Grounded in efficient coding, Bayesian and predictive frameworks, recurrent and attractor dynamics, neural state-space models, and systems neuroscience, the Principle of…
Joshua Justison, Gustavo A. Ballen, Carlos Acosta-Cortés, Roberto Ceja + 2 more
Phylogenetic networks extend the traditional tree model to capture reticulate evolutionary processes such as gene flow and hybridization. Among available inference tools, SNaQ is a widely used quartet-based method that offers a computationally efficient, statistically grounded approach to network estimation, but is…
Yuesong Wu, Haohao Su, Yuehua Cui
Cell-cell communication (CCC) is essential for maintaining tissue organization and driving biological progression, yet its inference from transcriptomic data has long been limited by the absence of spatial context. Advances in spatial transcriptomics (ST) now enable mechanistically grounded analyses of CCC by…
Xiaoyue Hu, Yuhao Ma, Ruixing Ming, Heping Zhang + 1 more
Identifying essential biomarkers remains a core challenge in elucidating the pathogenic mechanisms and achieving precise diagnosis of complex diseases. Deep neural networks offer immense predictive power, yet their lack of interpretability severely limits downstream biological insight. Here, we introduce DeepVaris, an…
Hadeer Kamal, Amira Y. Haikal, Mahmoud M. Saafan
Traffic collisions and congestion represent significant challenges within intelligent transportation systems (ITS). Consequently, a vehicular ad-hoc network (VANET) has been established. Numerous architectures have been incorporated into VANETs to manage the extensive data generated by vehicles. Collaboration with fog…
Hirotoshi Iihara, Giampaolo Bianchini, Matti Aapro, Luca Licata + 9 more
Purpose Nausea and vomiting beyond 5 days after emetogenic chemotherapy or antibody-drug conjugate (ADC) therapy are common, yet the role of neurokinin-1 (NK1) receptor antagonists in this setting remains underrecognized. We used pharmacokinetic/pharmacodynamic (PK/PD) modeling to estimate the NK1 receptor occupancy…
Bharadwaj Vemparala, Caroline Passaes, Delphine Desjardins, Valérie Monceaux + 18 more
While most people living with HIV suffer progressive disease following cessation of antiretroviral therapy, a small fraction elicits lasting post-treatment control. Understanding the mechanisms underlying this control is key to devising effective HIV remission strategies. Although recent studies implicate memory CD8 T…