17 papers · ranked by Valyu relevance
I. Pediaditakis, K. R. Kodella, D. V. Manatakis, C. Y. Le + 8 more
Species differences in the brain and the blood-brain barrier (BBB) biology hamper the translation from animal models to humans and impede the development of specific therapeutics for brain diseases. Here we present a human Brain-Chip engineered to recapitulate critical aspects of the complex brain cell-cell…
Eduardo Albornoz, Alberto A Amarilla, Naphak Modhiran, Sandra Parker + 25 more
Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however, an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe neurological manifestations, including precipitating cases of probable Parkinson’s disease. As microglial NLRP3 inflammasome activation is a major…
Chang Liu, Alfredo Cardenas-Rivera, Shayna Teitelbaum, Austin Birmingham + 2 more
Neuroinflammation, impaired metabolism, and hypoperfusion are fundamental pathological hallmarks of early Alzheimer’s disease (AD). Numerous studies have asserted a close association between neuroinflammation and disrupted cerebral energetics. During AD progression and other neurodegenerative disorders, a persistent…
Sadhana Sharma, Curtis Borski, Jessica Hanson, Micklaus A. Garcia + 4 more
Acute activation of innate immune response in the brain, or neuroinflammation, protects this vital organ from a range of external pathogens and promotes healing after traumatic brain injury. However, chronic neuroinflammation leads to the activation of immune cells like microglia and astrocytes causes damage to the…
Eugene Kim, Ines Carreira Figueiredo, Camilla Simmons, Karen Randall + 10 more
It is becoming increasingly apparent that neuroinflammation plays a critical role in an array of neurological and psychiatric disorders. Recent studies have demonstrated the potential of diffusion MRI (dMRI) to characterize changes in microglial density and morphology associated with neuroinflammation, but these were…
Kirstyn Gardner-Stephen, Robin J Carvajal-Quisilema, Lilya Andrianova, Rhona McGonigal + 7 more
Interactions between the brain and immune system play a key role in the aetiology of brain disorders, with inflammation emerging as a potential causal factor in subsets of major depressive disorder, particularly those resistant to treatment. The causal mechanisms through which immune activation can drive depressive…
Fan Li, Jazlyn Gallego, Natasha N Tirko, Jenna Greaser + 12 more
Microglia are important players in surveillance and repair of the brain. Their activation mediates neuroinflammation caused by intracortical microelectrode implantation, which impedes the application of intracortical brain-computer interfaces (BCIs). While low-intensity pulsed ultrasound stimulation (LIPUS) can…
Md Shamim Hossain, Shalman Dipto, Honsho Masanori, Tatsuo Okauchi + 2 more
Neuroinflammation is a key driver of neurodegenerative disorders, with chronic activation of the NF-κB pathway contributing to neuronal dysfunction and disease progression. In this study, we report that KIT-8, a synthetic alkyl ether lipid, exerts potent anti-inflammatory and neuroprotective effects despite its…
Isha Mhatre-Winters, Aseel Eid, Nicole Blum, Yoonhee Han + 3 more
Alzheimer’s disease (AD) is characterized by the presence of amyloid-β plaques, neurofibrillary tangles, and neuroinflammation. Previously, we reported serum levels of dichlorodiphenyldichloroethylene (DDE), the primary metabolite of the pesticide dichlorodiphenyltrichloroethane (DDT), were significantly higher in AD…
Xiang Gao, Wei Li, Fahim Syed, Fang Yuan + 2 more
Tissue damage and cellular destruction are the major events in traumatic brain injury (TBI), which trigger sterile neuroimmune and neuroinflammatory responses in the brain. While appropriate acute and transient neuroimmune and neuroinflammatory responses facilitate the repair and adaptation of injured brain tissues…
Sahil Threja, Nathan Ryzewski Strogulski, Janeen Laabei, Gloria Vegliante + 9 more
Traumatic brain injury (TBI) initiates a rapidly evolving neuroinflammatory response; however, the temporal relationship between early innate immune activation, T cell polarization, and neurobehavioural recovery remains poorly understood. Here, we hypothesize that interleukin-1β (IL-1β) is a critical upstream mediator…
Mario Villa-González, Marina Rubio, Gerardo Martín-López, Paula R Mallavibarrena + 4 more
Ischemic stroke is a sudden and acute disease characterized by neuronal death, glia activation, and a severe inflammatory process. Neuroinflammation is an early event after cerebral ischemia, with microglia playing a leading role. Microglial activation involves functional and morphological changes that drive a wide…
Changming Liu, Bingrui Zhu, Yuchun Liu, Qian Yu + 10 more
Subarachnoid hemorrhage (SAH) triggers a complex immune response that critically influences early brain injury (EBI) and long-term outcomes. However, the precise spatiotemporal dynamics and heterogeneity of immune cell infiltration and microglial reprogramming remain poorly understood. We aimed to construct a…
Sergio Castro-Gomez, Ana Vieira-Saecker, Juan Ignacio Muñoz-Manco, Tao Li + 7 more
NLRP3 plays an essential role in secondary neuroinflammatory damage following traumatic brain injury (TBI). However, the specific mechanisms mediating NLRP3’s effects in TBI remain poorly understood, and it is unknown whether its pharmacological inhibition with oral compounds during initial phases confers long-term…
Hao Yan, Xiangyang Cao, Meng Ma, Qianxiong He + 6 more
Ischemic stroke is a leading cause of disability and mortality, with neuroinflammation playing a key role in post-stroke injury. The molecular mechanisms remain incompletely defined. This study explored the functions of IRF7 and its downstream target ISG15 in stroke-associated neuroinflammation and prognosis of…
Victoria Kwon, Peiwen Cai, Cameron T. Dixon, Victoria Hamlin + 3 more
Inflammation is known to disrupt normal behavior, yet the underlying neuroimmune interactions remain elusive. Here, we investigated whether inappropriate macrophage-evoked inflammation alters CNS control of daily-life animal locomotion using a set of zebrafish mutants selected for specific macrophage dysfunction and…
Kristen D. Esannason Munroe, Alexandra V. Ulyanova, Rebecca Donahue, John D. Arena + 5 more
While a history of TBI is associated with an increased risk of neurodegenerative disease, associated mechanisms remain largely unknown. Neuroinflammation is commonly implicated as playing a role in progressive neurodegeneration in general, yet little is known about the adaptive response of neuroinflammation in TBI or…