13 papers · ranked by Valyu relevance
Alhamdu Adamu, Shuo Li, Fankai Gao, Guofang Xue
Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) to certain stimuli such as trauma, infection, and neurodegenerative diseases. This is a cellular immune response whereby glial cells are activated, inflammatory mediators are liberated and reactive oxygen and nitrogen species…
Yuanjie Sun, Yoshihisa Koyama, Shoichi Shimada
As inflammation in the brain contributes to several neurological and psychiatric diseases, the cause of neuroinflammation is being widely studied. The causes of neuroinflammation can be roughly divided into the following domains: viral infection, autoimmune disease, inflammation from peripheral organs, mental stress…
A. Bersano, J. Engele, M.K.E. Schäfer
Starting from the perspective of an immune-privileged site, our knowledge of the inflammatory processes within the central nervous system has increased rapidly over the last 30 years, leading to a rather puzzling picture today. Of particular interest is the emergence of disease- and injury-specific inflammatory…
She, Xutong
Alzheimer's disease (AD) persists as a paramount challenge in neurological research, characterized by the pathological hallmarks of amyloid-β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. This review synthesizes the evolving understanding of AD pathogenesis, moving beyond the linear…
Yejia Xu, Bowen Jia, Jing Li, Qianqian Li + 2 more
'Pamela A. Maher'] Central neurological disorders are significant contributors to morbidity, mortality, and long-term disability globally in modern society. These encompass neurodegenerative diseases, ischemic brain diseases, traumatic brain injury, epilepsy, depression, and more. The involved pathogenesis is notably…
She Xutong
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges. It is characterized by various pathological markers in the brain——large numbers ofamyloid plaques surrounded by neurons containing neurofibrillary tangles, vascular damage from extensive plaque…
Mario García-Domínguez, Wenqiang Fan
Neuroinflammation represents a fundamental component in the development and progression of a wide range of neurological disorders, including neurodegenerative diseases, psychiatric conditions, and cerebral injuries. This review examines the complex mechanisms underlying neuroinflammatory responses, with a focus on the…
Lucas Fornari Laurindo, Jefferson Aparecido Dias, Adriano Cressoni Araújo, Karina Torres Pomini + 10 more
'Adriano Cressoni Araújo' 'Karina Torres Pomini' 'Cristiano Machado Galhardi' 'Claudia Rucco Penteado Detregiachi' 'Luíza Santos de Argollo Haber' 'Domingos Donizeti Roque' 'Marcelo Dib Bechara' 'Marcela Vialogo Marques de Castro' 'Eliana de Souza Bastos Mazuqueli Pereira' 'Ricardo José Tofano' 'Iris Jasmin Santos…
Vandana Blossom, Sheetal D. Ullal, Melisha M. D’Souza, Anu V. Ranade + 2 more
'Nayanatara A. Kumar' 'Rajalakshmi Rai'] Neuroinflammation is known to be a contributing factor for several neurological disorders as well as cognitive dysfunction. Different signalling pathways, and a variety of supporting cells of CNS are suggested to be involved in the progression of neurodegeneration. Among the…
Vandana Blossom, Sheetal D. Ullal, Rajalakshmi Rai, Melisha Michael D souza + 4 more
'Melisha Michael D souza' 'P. Gopal Govind Kalluraya' 'Ayush Dixit' 'P. J. Jiji' 'B. V. Murlimanju'] The shared pathways between neuroinflammation and diabetes mellitus involve the NLRP3 inflammasome and subsequent production of the IL-1β. Chronic hyperactivation of hypothalamo-pituitary-adrenal axis and innate…
Marc Courchesne, Colin Wakefield, Karen Nygard, Patrick Burns + 4 more
'Gilles Fecteau' 'André Desrochers' 'Mingju Cao' 'Martin G. Frasch'] Biotron, Western University, London, ON, Canada Department of Biology, Western University, London, ON, Canada Drexel University College of Medicine, Philadelphia, PA, USA Dept. of Clinical Sciences, Faculty of Veterinary Medicine, Université de…
Emanuele Casali, Stefano A. Serapian, Eleonora Gianquinto, Matteo Castelli + 3 more
'Matteo Castelli' 'Massimo Bertinaria' 'Francesca Spyrakis' 'Giorgio Colombo'] The protein NLRP3 and its complexes are associated with an array of inflammatory pathologies, among which neurodegenerative, autoimmune, and metabolic diseases. Targeting the NLRP3 inflammasome represents a promising strategy for easing the…
Irina Kareva
Alzheimer's disease is not the outcome of a single cause but the convergence of many. This review reframes dementia as a systemic failure, where amyloid plaques and tau tangles are not root causes but late-stage byproducts of the underlying metabolic collapse. We begin by tracing the historical merger of early- and…