14 papers · ranked by Valyu relevance
Alhamdu Adamu, Shuo Li, Fankai Gao, Guofang Xue
Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) to certain stimuli such as trauma, infection, and neurodegenerative diseases. This is a cellular immune response whereby glial cells are activated, inflammatory mediators are liberated and reactive oxygen and nitrogen species…
Yuanjie Sun, Yoshihisa Koyama, Shoichi Shimada
As inflammation in the brain contributes to several neurological and psychiatric diseases, the cause of neuroinflammation is being widely studied. The causes of neuroinflammation can be roughly divided into the following domains: viral infection, autoimmune disease, inflammation from peripheral organs, mental stress…
A. Bersano, J. Engele, M.K.E. Schäfer
Starting from the perspective of an immune-privileged site, our knowledge of the inflammatory processes within the central nervous system has increased rapidly over the last 30 years, leading to a rather puzzling picture today. Of particular interest is the emergence of disease- and injury-specific inflammatory…
Yejia Xu, Bowen Jia, Jing Li, Qianqian Li + 2 more
'Pamela A. Maher'] Central neurological disorders are significant contributors to morbidity, mortality, and long-term disability globally in modern society. These encompass neurodegenerative diseases, ischemic brain diseases, traumatic brain injury, epilepsy, depression, and more. The involved pathogenesis is notably…
Mario García-Domínguez, Wenqiang Fan
Neuroinflammation represents a fundamental component in the development and progression of a wide range of neurological disorders, including neurodegenerative diseases, psychiatric conditions, and cerebral injuries. This review examines the complex mechanisms underlying neuroinflammatory responses, with a focus on the…
Lucas Fornari Laurindo, Jefferson Aparecido Dias, Adriano Cressoni Araújo, Karina Torres Pomini + 10 more
'Adriano Cressoni Araújo' 'Karina Torres Pomini' 'Cristiano Machado Galhardi' 'Claudia Rucco Penteado Detregiachi' 'Luíza Santos de Argollo Haber' 'Domingos Donizeti Roque' 'Marcelo Dib Bechara' 'Marcela Vialogo Marques de Castro' 'Eliana de Souza Bastos Mazuqueli Pereira' 'Ricardo José Tofano' 'Iris Jasmin Santos…
I. Pediaditakis, K. R. Kodella, D. V. Manatakis, C. Y. Le + 8 more
Species differences in the brain and the blood-brain barrier (BBB) biology hamper the translation from animal models to humans and impede the development of specific therapeutics for brain diseases. Here we present a human Brain-Chip engineered to recapitulate critical aspects of the complex brain cell-cell…
Vandana Blossom, Sheetal D. Ullal, Melisha M. D’Souza, Anu V. Ranade + 2 more
'Nayanatara A. Kumar' 'Rajalakshmi Rai'] Neuroinflammation is known to be a contributing factor for several neurological disorders as well as cognitive dysfunction. Different signalling pathways, and a variety of supporting cells of CNS are suggested to be involved in the progression of neurodegeneration. Among the…
Vandana Blossom, Sheetal D. Ullal, Rajalakshmi Rai, Melisha Michael D souza + 4 more
'Melisha Michael D souza' 'P. Gopal Govind Kalluraya' 'Ayush Dixit' 'P. J. Jiji' 'B. V. Murlimanju'] The shared pathways between neuroinflammation and diabetes mellitus involve the NLRP3 inflammasome and subsequent production of the IL-1β. Chronic hyperactivation of hypothalamo-pituitary-adrenal axis and innate…
Sadhana Sharma, Curtis Borski, Jessica Hanson, Micklaus A. Garcia + 4 more
Acute activation of innate immune response in the brain, or neuroinflammation, protects this vital organ from a range of external pathogens and promotes healing after traumatic brain injury. However, chronic neuroinflammation leads to the activation of immune cells like microglia and astrocytes causes damage to the…
Fan Li, Jazlyn Gallego, Natasha N Tirko, Jenna Greaser + 12 more
Microglia are important players in surveillance and repair of the brain. Their activation mediates neuroinflammation caused by intracortical microelectrode implantation, which impedes the application of intracortical brain-computer interfaces (BCIs). While low-intensity pulsed ultrasound stimulation (LIPUS) can…
Sahil Threja, Nathan Ryzewski Strogulski, Janeen Laabei, Gloria Vegliante + 9 more
Traumatic brain injury (TBI) initiates a rapidly evolving neuroinflammatory response; however, the temporal relationship between early innate immune activation, T cell polarization, and neurobehavioural recovery remains poorly understood. Here, we hypothesize that interleukin-1β (IL-1β) is a critical upstream mediator…
Sergio Castro-Gomez, Ana Vieira-Saecker, Juan Ignacio Muñoz-Manco, Tao Li + 7 more
NLRP3 plays an essential role in secondary neuroinflammatory damage following traumatic brain injury (TBI). However, the specific mechanisms mediating NLRP3’s effects in TBI remain poorly understood, and it is unknown whether its pharmacological inhibition with oral compounds during initial phases confers long-term…
Hao Yan, Xiangyang Cao, Meng Ma, Qianxiong He + 6 more
Ischemic stroke is a leading cause of disability and mortality, with neuroinflammation playing a key role in post-stroke injury. The molecular mechanisms remain incompletely defined. This study explored the functions of IRF7 and its downstream target ISG15 in stroke-associated neuroinflammation and prognosis of…